ID   HBL-100
AC   CVCL_4362
SY   HBL 100; HBL100
DR   BTO; BTO_0004734
DR   CLO; CLO_0003626
DR   EFO; EFO_0001167
DR   CLDB; cl1571
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-TABM-157
DR   ATCC; HTB-124
DR   BioSample; SAMN03152011
DR   BioSample; SAMN03471101
DR   BioSample; SAMN03472914
DR   CCRID; 1101HUM-PUMC000374
DR   CCRID; 3101HUMGNHu10
DR   CCTCC; GDC0195
DR   ChEMBL-Cells; CHEMBL3307713
DR   ChEMBL-Targets; CHEMBL614811
DR   CLS; 300178
DR   Cosmic; 687471
DR   Cosmic; 877447
DR   Cosmic; 934533
DR   Cosmic; 979722
DR   Cosmic; 991323
DR   Cosmic; 1010933
DR   Cosmic; 1136364
DR   Cosmic; 1176632
DR   Cosmic; 1434949
DR   Cosmic; 1524348
DR   Cosmic; 1609469
DR   DepMap; ACH-002321
DR   EGA; EGAS00001000610
DR   GEO; GSM1053697
DR   IARC_TP53; 21063
DR   LINCS_HMS; 51117
DR   PharmacoDB; HBL100_443_2019
DR   PubChem_Cell_line; CVCL_4362
DR   RCB; RCB0460
DR   TOKU-E; 3589
DR   Ubigene; YC-C013
DR   Wikidata; Q54881428
RX   CelloPub=CLPUB00368;
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RX   DOI=10.25904/1912/1434;
RX   PubMed=2547730;
RX   PubMed=2840847;
RX   PubMed=2995096;
RX   PubMed=3109929;
RX   PubMed=6500159;
RX   PubMed=6891286;
RX   PubMed=9671407;
RX   PubMed=10969801;
RX   PubMed=11416159;
RX   PubMed=12661003;
RX   PubMed=16643607;
RX   PubMed=17157791;
RX   PubMed=20143388;
RX   PubMed=24094812;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=28889351;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-297.html
CC   Problematic cell line: Misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (PubMed=16643607; PubMed=20143388). Originally thought to originate from a casein-producing breast cell line from a 27 year old Caucasian woman. In addition contains SV40 genomic sequence while the cell line was deemed to be spontaneously immortalized.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00207.
CC   Virology: Contains 2 copies of the SV40 genome, one complete the other incomplete tandemly integrated in the cell line genome.
CC   Doubling time: 28 hours (Note=At 10th passage) (PubMed=6891286); 1.5 days (PubMed=9671407); ~40 hours (CLS=300178); 30.21 hours (JWGray panel).
CC   HLA typing: A*01:01,02:01; B*08:01,40:01; C*03:04,07:01; DRB1*14:76,15:01 (PubMed=26589293).
CC   Karyotypic information: Near triploid with the modal number of 67 chromosomes (ATCC=HTB-124).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; HTB-124; true.
CC   Discontinued: RCB; RCB0460; true.
ST   Source(s): ATCC=HTB-124; CCRID; CLS=300178; PubMed=11416159; PubMed=25877200; PubMed=28889351
ST   Amelogenin: X (CCRID; PubMed=25877200; PubMed=28889351)
ST   Amelogenin: X,Y (ATCC=HTB-124; CLS=300178; PubMed=11416159)
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 9,12
ST   D18S51: 16
ST   D19S433: 15
ST   D21S11: 28,30
ST   D2S1338: 18,24
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,15
ST   FGA: 25
ST   Penta D: 12
ST   Penta E: 7
ST   TH01: 6,8
ST   TPOX: 8
ST   vWA: 16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 39
CH   CVCL_A5RV ! HBLT-11
CH   CVCL_A5RW ! HBLT-12
CH   CVCL_A5RX ! HBLT-13
//
RX   PubMed=2547730; DOI=10.1002/ijc.2910440230;
RA   Saint-Ruf, Claude
RA   Nardeux, Pierre-Claude
RA   Cebrian, Jose
RA   Lacasa, Michel
RA   Lavialle, Christian
RA   Cassingena, Roland
RT   "Molecular cloning and characterization of endogenous SV40 DNA from
RT   human HBL-100 cells.";
RL   Int. J. Cancer 44:367-372(1989).
//
RX   PubMed=2995096; DOI=10.1016/0014-4827(85)90238-1;
RA   Caron de Fromentel, Claude
RA   Nardeux, Pierre-Claude
RA   Soussi, Thierry
RA   Lavialle, Christian
RA   Estrade, Simone
RA   Carloni, Guido
RA   Chandrasekaran, Karthikeyan
RA   Cassingena, Roland
RT   "Epithelial HBL-100 cell line derived from milk of an apparently
RT   healthy woman harbours SV40 genetic information.";
RL   Exp. Cell Res. 160:83-94(1985).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz, Susanne
RA   Wassmuth, Peter
RA   Plaschke, Jens
RA   Schackert, Hans Konrad
RA   Karsten, Uwe
RA   Santibanez-Koref, Mauro F.
RA   Schlag, Peter Michael
RA   Scherneck, Siegfried
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=6500159; DOI=10.1159/000163283;
RA   Gershwin, Merrill Eric
RA   Lentz, Daniel
RA   Owens, Robert B.
RT   "Relationship between karyotype of tissue culture lines and
RT   tumorigenicity in nude mice.";
RL   Exp. Cell Biol. 52:361-370(1984).
//
RX   CelloPub=CLPUB00368;
RA   Polanowski, Frank P.
RA   Gaffney, Edwin V.
RA   Burke, Robert E.
RT   "HBL-100, a cell line established from human breast milk.";
RL   In Vitro 12:328-328(1976).
//
RX   DOI=10.25904/1912/1434;
RA   Morrison, Brian J.
RT   "Breast cancer stem cells: tumourspheres and implications for therapy.";
RL   Thesis PhD (2010); Griffith University; Brisbane; Australia.
//
RX   PubMed=16643607; DOI=10.1111/j.1749-0774.2005.00007.x;
RA   Yoshino, Kaori
RA   Iimura, Emi
RA   Saijo, Kaoru
RA   Iwase, Satsuki
RA   Fukami, Kiyoko
RA   Ohno, Tadao
RA   Obata, Yuichi
RA   Nakamura, Yukio
RT   "Essential role for gene profiling analysis in the authentication of
RT   human cell lines.";
RL   Hum. Cell 19:43-48(2006).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   DOI=10.1016/B978-0-12-333530-2.50009-5;
RA   Leibovitz, Albert
RT   "Cell lines from human breast.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994).
//
RX   PubMed=10969801;
RA   Forozan, Farahnaz
RA   Mahlamaki, Eija H.
RA   Monni, Outi
RA   Chen, Yi-Dong
RA   Veldman, Robin
RA   Jiang, Yuan
RA   Gooden, Gerald C.
RA   Ethier, Stephen P.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RT   "Comparative genomic hybridization analysis of 38 breast cancer cell
RT   lines: a basis for interpreting complementary DNA microarray data.";
RL   Cancer Res. 60:4519-4525(2000).
//
RX   PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310;
RA   Timmerman, Luika A.
RA   Holton, Thomas
RA   Yuneva, Mariia
RA   Louie, Raymond J.
RA   Padro, Merce
RA   Daemen, Anneleen
RA   Hu, Min
RA   Chan, Denise A.
RA   Ethier, Stephen P.
RA   van 't Veer, Laura J.
RA   Polyak, Kornelia
RA   McCormick, Frank
RA   Gray, Joe W.
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=3109929; DOI=10.1016/0014-4827(87)90318-1;
RA   Dealtry, Gillian B.
RA   Naylor, M. Stuart
RA   Fiers, Walter Charles
RA   Balkwill, Frances Rosemary
RT   "The effect of recombinant human tumour necrosis factor on growth and
RT   macromolecular synthesis of human epithelial cells.";
RL   Exp. Cell Res. 170:428-438(1987).
//
RX   PubMed=6891286; DOI=10.1007/BF00204786;
RA   Gaffney, Edwin V.
RT   "A cell line (HBL-100) established from human breast milk.";
RL   Cell Tissue Res. 227:563-568(1982).
//
RX   PubMed=9671407; DOI=10.1038/sj.onc.1201814;
RA   Sweeney, Kimberley J.
RA   Swarbrick, Alexander
RA   Sutherland, Robert Lyndsay
RA   Musgrove, Elizabeth A.
RT   "Lack of relationship between CDK activity and G1 cyclin expression in
RT   breast cancer cells.";
RL   Oncogene 16:2865-2878(1998).
//
RX   PubMed=28889351; DOI=10.1007/s10549-017-4496-x;
RA   Saunus, Jodi M.
RA   Smart, Chanel E.
RA   Kutasovic, Jamie R.
RA   Johnston, Rebecca L.
RA   Kalita-de Croft, Priyakshi
RA   Miranda, Mariska
RA   Rozali, Esdy N.
RA   Vargas, Ana Cristina
RA   Reid, Lynne E.
RA   Lorsy, Eva
RA   Cocciardi, Sibylle
RA   Seidens, Tatjana
RA   McCart Reed, Amy Ellen
RA   Dalley, Andrew J.
RA   Wockner, Leesa F.
RA   Johnson, Julie
RA   Sarkar, Debina
RA   Askarian-Amiri, Marjan E.
RA   Simpson, Peter T.
RA   Khanna, Kum Kum
RA   Chenevix-Trench, Georgia
RA   Al-Ejeh, Fares
RA   Lakhani, Sunil R.
RT   "Multidimensional phenotyping of breast cancer cell lines to guide
RT   preclinical research.";
RL   Breast Cancer Res. Treat. 167:289-301(2018).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=2840847;
RA   Marlhens, Francoise
RA   Saint-Ruf, Claude
RA   Nardeux, Pierre-Claude
RA   Lavialle, Christian
RA   Brouty-Boye, Daniele
RA   Dutrillaux, Bernard
RA   Cassingena, Roland
RT   "Karyotype evolution of the human HBL-100 cell line and mapping of the
RT   integration site of SV40 DNA.";
RL   Ann. Genet. 31:81-86(1988).
//