ID   TOV-1946
AC   CVCL_4062
SY   TOV1946
DR   cancercelllines; CVCL_4062
DR   CancerTools; 161770
DR   Cosmic; 1122314
DR   GEO; GSM2475007
DR   Wikidata; Q54972807
RX   PubMed=18507860;
RX   PubMed=22585861;
RX   PubMed=22931248;
RX   PubMed=28273451;
CC   Doubling time: 1.3 +- 0.4 days (PubMed=18507860); 2.2 +- 0.26 days (PubMed=22931248).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=18507860; PubMed=22931248; PubMed=28273451).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: STR profile from personal communication of Mes-Masson, Anne-Marie.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12
ST   D16S539: 11
ST   D21S11: 30
ST   D5S818: 11
ST   D7S820: 11,12
ST   TH01: 9,9.3
ST   TPOX: 8,10
ST   vWA: 14,15
DI   NCIt; C105555; High grade ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_4375 ! OV-1946
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 21
//
RX   PubMed=22931248; DOI=10.1186/1471-2407-12-379; PMCID=PMC3532154;
RA   Letourneau, Isabelle J.
RA   Quinn, Michael C.J.
RA   Wang, Lu-Lin
RA   Portelance, Lise
RA   Caceres, Katia Y.
RA   Cyr, Louis
RA   Delvoye, Nathalie
RA   Meunier, Liliane
RA   de Ladurantaye, Manon
RA   Shen, Zhen
RA   Arcand, Suzanna L.
RA   Tonin, Patricia N.
RA   Provencher, Diane Michele
RA   Mes-Masson, Anne-Marie
RT   "Derivation and characterization of matched cell lines from primary
RT   and recurrent serous ovarian cancer.";
RL   BMC Cancer 12:379.1-379.16(2012).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte, Richard
RA   Brown, Kevin R.
RA   Suarez Saiz, Fernando Jose
RA   Sayad, Azin
RA   Karamboulas, Konstantina
RA   Krzyzanowski, Paul M.
RA   Sircoulomb, Fabrice
RA   Medrano, Mauricio
RA   Fedyshyn, Yaroslav
RA   Koh, Judice Lie-Yong
RA   van Dyk, Dewald
RA   Fedyshyn, Bohdana
RA   Luhova, Marianna
RA   Brito, Glauber C.
RA   Vizeacoumar, Franco J.
RA   Vizeacoumar, Frederick S.
RA   Datti, Alessandro
RA   Kasimer, Dahlia
RA   Buzina, Alla
RA   Mero, Patricia
RA   Misquitta, Christine
RA   Normand, Josee
RA   Haider, Maliha
RA   Ketela, Troy
RA   Wrana, Jeffrey L.
RA   Rottapel, Robert
RA   Neel, Benjamin G.
RA   Moffat, Jason
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
RX   PubMed=18507860; DOI=10.1186/1471-2407-8-152; PMCID=PMC2467432;
RA   Ouellet, Veronique
RA   Zietarska, Magdalena
RA   Portelance, Lise
RA   Lafontaine, Julie
RA   Madore, Jason
RA   Puiffe, Marie-Line
RA   Arcand, Suzanna L.
RA   Shen, Zhen
RA   Hebert, Josee
RA   Tonin, Patricia N.
RA   Provencher, Diane Michele
RA   Mes-Masson, Anne-Marie
RT   "Characterization of three new serous epithelial ovarian cancer cell
RT   lines.";
RL   BMC Cancer 8:152.1-152.18(2008).
//
RX   PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028;
RA   Medrano, Mauricio
RA   Communal, Laudine
RA   Brown, Kevin R.
RA   Iwanicki, Marcin
RA   Normand, Josee
RA   Paterson, Joshua
RA   Sircoulomb, Fabrice
RA   Krzyzanowski, Paul M.
RA   Novak, Marian
RA   Doodnauth, Sasha A.
RA   Suarez Saiz, Fernando Jose
RA   Cullis, Jane
RA   Al-awar, Rima
RA   Neel, Benjamin G.
RA   McPherson, John
RA   Drapkin, Ronny I.
RA   Ailles, Laurie
RA   Mes-Masson, Anne-Marie
RA   Rottapel, Robert
RT   "Interrogation of functional cell-surface markers identifies CD151
RT   dependency in high-grade serous ovarian cancer.";
RL   Cell Rep. 18:2343-2358(2017).
//