ID   T3M-4
AC   CVCL_4056
SY   T3M4; Panc89; Panc-89; PANC-89; Panc 89
DR   BTO; BTO:0002864
DR   CLO; CLO_0050113
DR   EFO; EFO_0002714
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 452
DR   BioSample; SAMN03472207
DR   BioSample; SAMN10988105
DR   cancercelllines; CVCL_4056
DR   CCRID; 1101HUM-PUMC000815
DR   Cell_Model_Passport; SIDM01469
DR   Cosmic; 710873
DR   Cosmic; 724641
DR   Cosmic; 736281
DR   Cosmic; 922257
DR   Cosmic; 922263
DR   Cosmic; 933528
DR   Cosmic; 2546061
DR   Cosmic; 2546062
DR   DepMap; ACH-000085
DR   GEO; GSM887684
DR   GEO; GSM888776
DR   GEO; GSM1374814
DR   GEO; GSM1374815
DR   GEO; GSM1374816
DR   IARC_TP53; 1561
DR   IARC_TP53; 16746
DR   LiGeA; CCLE_195
DR   PharmacoDB; T3M4_1557_2019
DR   Progenetix; CVCL_4056
DR   RCB; RCB1021
DR   Wikidata; Q54971538
RX   PubMed=6821838;
RX   PubMed=8426738;
RX   PubMed=11169959;
RX   PubMed=11787853;
RX   PubMed=12692724;
RX   PubMed=18298655;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/T3M-4.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: KuDOS 95 cell line panel.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000177881; Zygosity=Heterozygous (PubMed=8426738; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=8426738; PubMed=11169959; PubMed=11787853; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0.38%; Native American=0.38%; East Asian, North=79.41%; East Asian, South=19.66%; South Asian=0%; European, North=0%; European, South=0.16% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): CCRID; RCB
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D12S391: 20,21,24
ST   D13S317: 10,13 (RCB)
ST   D13S317: 13 (CCRID)
ST   D16S539: 11,12
ST   D18S51: 16
ST   D19S433: 14
ST   D21S11: 32.2,33.2
ST   D2S1338: 17,25
ST   D3S1358: 14,15
ST   D5S818: 11
ST   D6S1043: 10,11
ST   D7S820: 12
ST   D8S1179: 16
ST   FGA: 25
ST   Penta E: 11,12
ST   TH01: 9.3
ST   TPOX: 11,12
ST   vWA: 18,19,21
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 30
//
RX   PubMed=6821838; DOI=10.1002/1097-0142(19830215)51:4<662::AID-CNCR2820510419>3.0.CO;2-X;
RA   Okabe T., Yamaguchi N., Ohsawa N.;
RT   "Establishment and characterization of a carcinoembryonic antigen
RT   (CEA)-producing cell line from a human carcinoma of the exocrine
RT   pancreas.";
RL   Cancer 51:662-668(1983).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.;
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//
RX   PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x;
RA   Pilarsky C., Ammerpohl O., Sipos B., Dahl E., Hartmann A.,
RA   Wellmann A., Braunschweig T., Lohr J.-M., Jesenofsky R., Friess H.,
RA   Wente M.N., Kristiansen G., Jahnke B., Denz A., Ruckert F.,
RA   Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.;
RT   "Activation of Wnt signalling in stroma from pancreatic cancer
RT   identified by gene expression profiling.";
RL   J. Cell. Mol. Med. 12:2823-2835(2008).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//