ID   RBA-2
AC   CVCL_4031
SY   RBA2; Rat Brain Astrocyte-2
DR   BTO; BTO_0002599
DR   BCRC; 60584
DR   Wikidata; Q54949328
RX   PubMed=10386986;
RX   PubMed=11746779;
RX   PubMed=15985361;
RX   PubMed=16178011;
RX   PubMed=18067549;
CC   Characteristics: Type-2 astrocyte. A2B5, GFAP and glutamine synthetase positive (PubMed=10386986).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Cell type: Astrocyte; CL=CL_0000127.
CC   Breed/subspecies: JAR-2.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0494 ! RBA-1
SX   Sex unspecified
AG   3D
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 14
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RX   PubMed=10386986; DOI=10.1046/j.1471-4159.1999.0730334.x;
RA   Sun S.H., Lin L.-B., Hung A.C., Kuo J.-S.;
RT   "ATP-stimulated Ca2+ influx and phospholipase D activities of a rat
RT   brain-derived type-2 astrocyte cell line, RBA-2, are mediated through
RT   P2X7 receptors.";
RL   J. Neurochem. 73:334-343(1999).
//
RX   PubMed=11746779; DOI=10.1002/glia.10004;
RA   Wang C.-M., Chang Y.-Y., Kuo J.-S., Sun S.H.;
RT   "Activation of P2X(7) receptors induced [(3)H]GABA release from the
RT   RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent
RT   mechanism.";
RL   Glia 37:8-18(2002).
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RX   PubMed=15985361; DOI=10.1016/j.cellsig.2005.02.009;
RA   Hung A.C., Chu Y.-J., Lin Y.-H., Weng J.-Y., Chen H.B., Au Y.-C.,
RA   Sun S.H.;
RT   "Roles of protein kinase C in regulation of P2X7 receptor-mediated
RT   calcium signalling of cultured type-2 astrocyte cell line, RBA-2.";
RL   Cell. Signal. 17:1384-1396(2005).
//
RX   PubMed=16178011; DOI=10.1002/jcb.205;
RA   Chen H.B., Chan Y.-T., Hung A.C., Tsai Y.-C., Sun S.H.;
RT   "Elucidation of ATP-stimulated stress protein expression of RBA-2
RT   type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and
RT   stimulates pI shift of peroxiredoxin II.";
RL   J. Cell. Biochem. 97:314-326(2006).
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RX   PubMed=18067549; DOI=10.1111/j.1471-4159.2007.05119.x;
RA   Lo J.-C., Huang W.-C., Chou Y.-C., Tseng C.-H., Lee W.-L., Sun S.H.;
RT   "Activation of P2X(7) receptors decreases glutamate uptake and
RT   glutamine synthetase activity in RBA-2 astrocytes via distinct
RT   mechanisms.";
RL   J. Neurochem. 105:151-164(2008).
//