ID   SCC-13
AC   CVCL_4029
SY   SCC 13; SCC13
DR   BTO; BTO_0002193
DR   BioGRID_ORCS_Cell_line; 1574
DR   cancercelllines; CVCL_4029
DR   Cosmic; 740990
DR   IARC_TP53; 1911
DR   IGRhCellID; SCC13%20GSE9585
DR   PRIDE; PXD023701
DR   TOKU-E; 3610
DR   Wikidata; Q54952336
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=2573646;
RX   PubMed=3417487;
RX   PubMed=3458227;
RX   PubMed=6722007;
RX   PubMed=7214336;
RX   PubMed=8390283;
RX   PubMed=11992403;
RX   PubMed=17312569;
RX   PubMed=22546478;
RX   PubMed=22564525;
RX   PubMed=34435183;
RX   PubMed=34593609;
CC   Doubling time: 1 day (PubMed=34435183).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu258Lys (c.772G>A); ClinVar=VCV000012348; Zygosity=Unspecified (PubMed=8390283; PubMed=11992403).
CC   Omics: Proteomics; Quantitative.
CC   Derived from site: In situ; Face, skin; UBERON=UBERON_1000021.
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994).
//
RX   PubMed=2573646; DOI=10.1080/09553008914551731;
RA   Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.;
RT   "Radiobiological characterization of 53 human tumor cell lines.";
RL   Int. J. Radiat. Biol. 56:553-560(1989).
//
RX   PubMed=3417487; DOI=10.1016/0360-3016(88)90297-0;
RA   Weichselbaum R.R., Beckett M.A., Schwartz J.L., Dritschilo A.;
RT   "Radioresistant tumor cells are present in head and neck carcinomas
RT   that recur after radiotherapy.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:575-579(1988).
//
RX   PubMed=3458227; DOI=10.1073/pnas.83.8.2684; PMCID=PMC323364;
RA   Weichselbaum R.R., Dahlberg W.K., Beckett M.A., Karrison T., Miller D.,
RA   Clark J., Ervin T.J.;
RT   "Radiation-resistant and repair-proficient human tumor cells may be
RT   associated with radiotherapy failure in head- and neck-cancer
RT   patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986).
//
RX   PubMed=6722007; DOI=10.1038/bjc.1984.94; PMCID=PMC1976725;
RA   Weichselbaum R.R., Dahlberg W.K., Little J.B., Ervin T.J., Miller D.,
RA   Hellman S., Rheinwald J.G.;
RT   "Cellular X-ray repair parameters of early passage squamous cell
RT   carcinoma lines derived from patients with known responses to
RT   radiotherapy.";
RL   Br. J. Cancer 49:595-601(1984).
//
RX   PubMed=7214336;
RA   Rheinwald J.G., Beckett M.A.;
RT   "Tumorigenic keratinocyte lines requiring anchorage and fibroblast
RT   support cultured from human squamous cell carcinomas.";
RL   Cancer Res. 41:1657-1663(1981).
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238; PMCID=PMC1968513;
RA   Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G.,
RA   Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.;
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=11992403; DOI=10.1002/ijc.10321;
RA   Popp S., Waltering S., Herbst C., Moll I., Boukamp P.;
RT   "UV-B-type mutations and chromosomal imbalances indicate common
RT   pathways for the development of Merkel and skin squamous cell
RT   carcinomas.";
RL   Int. J. Cancer 99:352-360(2002).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028; PMCID=PMC3378915;
RA   Degen M., Natarajan E., Barron P., Widlund H.R., Rheinwald J.G.;
RT   "MAPK/ERK-dependent translation factor hyperactivation and
RT   dysregulated laminin gamma2 expression in oral dysplasia and squamous
RT   cell carcinoma.";
RL   Am. J. Pathol. 180:2462-2478(2012).
//
RX   PubMed=22564525; DOI=10.1158/0008-5472.CAN-12-0423; PMCID=PMC3428932;
RA   Goldie S.J., Mulder K.W., Tan D.W.-M., Lyons S.K., Sims A.H., Watt F.M.;
RT   "FRMD4A upregulation in human squamous cell carcinoma promotes tumor
RT   growth and metastasis and is associated with poor prognosis.";
RL   Cancer Res. 72:3424-3436(2012).
//
RX   PubMed=34435183; DOI=10.1016/j.mbplus.2021.100066; PMCID=PMC8377039;
RA   Vu B., Souza G.R., Dengjel J.;
RT   "Scaffold-free 3D cell culture of primary skin fibroblasts induces
RT   profound changes of the matrisome.";
RL   Matrix Biol. Plus 11:100066.1-100066.9(2021).
//
RX   PubMed=34593609; DOI=10.1158/1541-7786.MCR-21-0306; PMCID=PMC10088464;
RA   Chen X., Adhikary G., Shrestha S., Xu W., Keillor J.W., Naselsky W.,
RA   Eckert R.L.;
RT   "Transglutaminase 2 maintains hepatocyte growth factor signaling to
RT   enhance the cancer cell phenotype.";
RL   Mol. Cancer Res. 19:2026-2035(2021).
//