ID   PancTu-I
AC   CVCL_4012
SY   PancTu-1; PancTu 1; Panc-TU-I; Panc-Tu1; Panc-TuI; Panc Tu-I; Panc TUI; PancTuI; PancTUI; PaTu-I; PaTu I; PatuI; PaTu1
DR   EFO; EFO_0002715
DR   cancercelllines; CVCL_4012
DR   Cosmic; 710865
DR   Cosmic; 736275
DR   Cosmic; 933530
DR   Cosmic; 1534321
DR   GEO; GSM244424
DR   Progenetix; CVCL_4012
DR   Wikidata; Q54937559
RX   CelloPub=CLPUB00416;
RX   PubMed=8426738;
RX   PubMed=11169959;
RX   PubMed=11787853;
RX   PubMed=12692724;
RX   PubMed=12800145;
RX   PubMed=18298655;
RX   PubMed=19077451;
WW   https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/PaTu%201.html
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys176Ser (c.526T>A); ClinVar=VCV000376570; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959; PubMed=11787853).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by microarray.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_4013 ! PancTu-II
SX   Female
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 20
//
RX   CelloPub=CLPUB00416;
RA   Oberlin L.;
RT   "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a
RT   monoclonal antibody against the transferrin receptor.";
RL   Thesis VMD (2009), Justus-Liebig-Universitat Giessen, Germany.
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.;
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
RA   Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D.,
RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x;
RA   Pilarsky C., Ammerpohl O., Sipos B., Dahl E., Hartmann A.,
RA   Wellmann A., Braunschweig T., Lohr J.-M., Jesenofsky R., Friess H.,
RA   Wente M.N., Kristiansen G., Jahnke B., Denz A., Ruckert F.,
RA   Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.;
RT   "Activation of Wnt signalling in stroma from pancreatic cancer
RT   identified by gene expression profiling.";
RL   J. Cell. Mol. Med. 12:2823-2835(2008).
//
RX   PubMed=19077451; DOI=10.1159/000178871;
RA   Harada T., Chelala C., Crnogorac-Jurcevic T., Lemoine N.R.;
RT   "Genome-wide analysis of pancreatic cancer using microarray-based
RT   techniques.";
RL   Pancreatology 9:13-24(2009).
//