ID   KOCL-45
AC   CVCL_3993
SY   KOCL45
DR   BTO; BTO_0004939
DR   cancercelllines; CVCL_3993
DR   Cosmic; 996297
DR   Cosmic; 1037747
DR   IARC_TP53; 28411
DR   Wikidata; Q54900280
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1465024;
RX   PubMed=8180386;
RX   PubMed=9529133;
RX   PubMed=9738977;
RX   PubMed=10360377;
RX   PubMed=10995006;
RX   PubMed=14504097;
RX   PubMed=14671638;
RX   PubMed=20519628;
RX   PubMed=20575032;
RX   PubMed=28569787;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:7135; AFF1 + HGNC; HGNC:7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4 (PubMed=14671638).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; p.Glu1099Lys (c.3295G>A); ClinVar=VCV000638278; Zygosity=Heterozygous (PubMed=35124168).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=20575032).
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 24
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L;
RA   Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y.,
RA   Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T.,
RA   Ueda R., Nakazawa S.;
RT   "Phenotypic and genotypic characterization of 14 leukemia and lymphoma
RT   cell lines with 11q23 translocations.";
RL   Leuk. Res. 16:1155-1163(1992).
//
RX   PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912;
RA   Yamamoto K., Seto M., Iida S., Komatsu H., Kamada N., Kojima S.,
RA   Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.;
RT   "A reverse transcriptase-polymerase chain reaction detects
RT   heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.";
RL   Blood 83:2912-2921(1994).
//
RX   PubMed=9529133; DOI=10.1038/sj.leu.2400951;
RA   Inukai T., Sugita K., Iijima K., Goi K., Tezuka T., Kojika S.,
RA   Kagami K., Mori T., Kinoshita A., Suzuki T., Koyama-Okazaki T.,
RA   Nakazawa S.;
RT   "Leukemic cells with 11q23 translocations express granulocyte
RT   colony-stimulating factor (G-CSF) receptor and their proliferation is
RT   stimulated with G-CSF.";
RL   Leukemia 12:382-389(1998).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=10360377; DOI=10.1038/sj.leu.2401437;
RA   Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T.,
RA   Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K.,
RA   Koyama-Okazaki T., Mori T., Nakazawa S.;
RT   "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in
RT   childhood acute lymphoblastic leukemia with 11q23 translocation.";
RL   Leukemia 13:884-890(1999).
//
RX   PubMed=10995006; DOI=10.1038/sj.leu.2401893;
RA   Iijima K., Sugita K., Inukai T., Goi K., Tezuka T., Uno K., Sato H.,
RA   Kagami K., Nakazawa S.;
RT   "Expression of thrombopoietin receptor and its functional role in
RT   human B-precursor leukemia cells with 11q23 translocation or
RT   Philadelphia chromosome.";
RL   Leukemia 14:1598-1605(2000).
//
RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=20519628; DOI=10.1182/blood-2009-09-244673;
RA   Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H.,
RA   Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H.,
RA   Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K.,
RA   Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.;
RT   "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription
RT   factor and its implication in leukemogenesis of B-precursor ALL with
RT   t(17;19).";
RL   Blood 116:962-970(2010).
//
RX   PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455;
RA   Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I.,
RA   Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i.,
RA   Tada M., Moriuchi T., Sugita K.;
RT   "A specific linkage between the incidence of TP53 mutations and type
RT   of chromosomal translocations in B-precursor acute lymphoblastic
RT   leukemia cell lines.";
RL   Am. J. Hematol. 85:535-537(2010).
//
RX   PubMed=28569787; DOI=10.1038/cddis.2017.249; PMCID=PMC5520907;
RA   Kasai S., Furuichi Y., Ando N., Kagami K., Abe M., Nakane T., Goi K.,
RA   Inukai T., Saitoh S., Ohno S., Okazaki S., Nagano O., Saya H.,
RA   Sugita K.;
RT   "Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers
RT   necrosis of B-precursor leukemia cells with high surface CD44
RT   expression.";
RL   Cell Death Dis. 8:e2857.1-e2857.11(2017).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//