ID   WEHI-7.2
AC   CVCL_3950
SY   WEHI 7.2; WEHI7.2
DR   BTO; BTO_0003181
DR   Lonza; 1003
DR   Wikidata; Q54993771
RX   PubMed=8022822;
RX   PubMed=9371519;
RX   PubMed=11289160;
RX   PubMed=11526450;
RX   PubMed=12203227;
RX   PubMed=15702245;
RX   PubMed=17180014;
CC   Characteristics: Treatment with dexamethasone, a synthetic glucocorticoid, causes the cells to undergo apoptosis (PubMed=17180014).
CC   Doubling time: 13.78 +- 0.38 hours (PubMed=11526450).
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
CC   Breed/subspecies: BALB/c.
DI   NCIt; C198577; Mouse thymoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_F526 ! WEHI-7
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 10
//
RX   PubMed=8022822; DOI=10.1073/pnas.91.14.6569; PMCID=PMC44244;
RA   Lam M., Dubyak G.R., Chen L., Nunez G., Miesfeld R.L., Distelhorst C.W.;
RT   "Evidence that BCL-2 represses apoptosis by regulating endoplasmic
RT   reticulum-associated Ca2+ fluxes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:6569-6573(1994).
//
RX   PubMed=9371519;
RA   Baker A., Payne C.M., Briehl M.M., Powis G.;
RT   "Thioredoxin, a gene found overexpressed in human cancer, inhibits
RT   apoptosis in vitro and in vivo.";
RL   Cancer Res. 57:5162-5167(1997).
//
RX   PubMed=11289160;
RA   Tome M.E., Baker A.F., Powis G., Payne C.M., Briehl M.M.;
RT   "Catalase-overexpressing thymocytes are resistant to
RT   glucocorticoid-induced apoptosis and exhibit increased net tumor
RT   growth.";
RL   Cancer Res. 61:2766-2773(2001).
//
RX   PubMed=11526450; DOI=10.1038/sj.cdd.4400904;
RA   Tome M.E., Briehl M.M.;
RT   "Thymocytes selected for resistance to hydrogen peroxide show altered
RT   antioxidant enzyme profiles and resistance to dexamethasone-induced
RT   apoptosis.";
RL   Cell Death Differ. 8:953-961(2001).
//
RX   PubMed=12203227; DOI=10.1002/nbm.790;
RA   Lutz N.W., Tome M.E., Aiken N.R., Briehl M.M.;
RT   "Changes in phosphate metabolism in thymoma cells suggest mechanisms
RT   for resistance to dexamethasone-induced apoptosis. A 31P NMR
RT   spectroscopic study of cell extracts.";
RL   NMR Biomed. 15:356-366(2002).
//
RX   PubMed=15702245; DOI=10.3892/ijmm.15.3.497;
RA   Tome M.E., Briehl M.M., Lutz N.W.;
RT   "Increasing the antioxidant defense in WEHI7.2 cells results in a more
RT   tumor-like metabolic profile.";
RL   Int. J. Mol. Med. 15:497-501(2005).
//
RX   PubMed=17180014;
RA   Briehl M.M., Cotgreave I.A., Powis G.;
RT   "Downregulation of the antioxidant defence during
RT   glucocorticoid-mediated apoptosis.";
RL   Cell Death Differ. 2:41-46(1995).
//