ID   KOPN-1
AC   CVCL_3937
SY   Kopn-1; KOPN1
DR   BTO; BTO:0004944
DR   cancercelllines; CVCL_3937
DR   Cosmic; 996302
DR   Cosmic; 1037721
DR   Cosmic; 2391172
DR   IARC_TP53; 28407
DR   Wikidata; Q54900299
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1465024;
RX   PubMed=8180386;
RX   PubMed=9738977;
RX   PubMed=10360377;
RX   PubMed=14504097;
RX   PubMed=14671638;
RX   PubMed=15843827;
RX   PubMed=20519628;
RX   PubMed=20575032;
RX   PubMed=28569787;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; 7132; KMT2A + HGNC; 7134; MLLT1; Name(s)=KMT2A-MLLT1, MLL-MLLT1; MLL-ENL (PubMed=14671638; PubMed=15843827).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=20575032).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   9M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001).
//
RX   PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L;
RA   Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y.,
RA   Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T.,
RA   Ueda R., Nakazawa S.;
RT   "Phenotypic and genotypic characterization of 14 leukemia and lymphoma
RT   cell lines with 11q23 translocations.";
RL   Leuk. Res. 16:1155-1163(1992).
//
RX   PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912;
RA   Yamamoto K., Seto M., Iida S., Komatsu H., Kamada N., Kojima S.,
RA   Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.;
RT   "A reverse transcriptase-polymerase chain reaction detects
RT   heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.";
RL   Blood 83:2912-2921(1994).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=10360377; DOI=10.1038/sj.leu.2401437;
RA   Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T.,
RA   Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K.,
RA   O-Koyama T., Mori T., Nakazawa S.;
RT   "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in
RT   childhood acute lymphoblastic leukemia with 11q23 translocation.";
RL   Leukemia 13:884-890(1999).
//
RX   PubMed=14504097; DOI=10.1182/blood-2003-02-0418;
RA   Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R.,
RA   Tsuchida M., Sugita K., Ida K., Hayashi Y.;
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J.,
RA   Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M.,
RA   Fioretos T.;
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=20519628; DOI=10.1182/blood-2009-09-244673;
RA   Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H.,
RA   Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H.,
RA   Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K.,
RA   Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.;
RT   "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription
RT   factor and its implication in leukemogenesis of B-precursor ALL with
RT   t(17;19).";
RL   Blood 116:962-970(2010).
//
RX   PubMed=20575032; DOI=10.1002/ajh.21738;
RA   Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I.,
RA   Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i.,
RA   Tada M., Moriuchi T., Sugita K.;
RT   "A specific linkage between the incidence of TP53 mutations and type
RT   of chromosomal translocations in B-precursor acute lymphoblastic
RT   leukemia cell lines.";
RL   Am. J. Hematol. 85:535-537(2010).
//
RX   PubMed=28569787; DOI=10.1038/cddis.2017.249;
RA   Kasai S., Furuichi Y., Ando N., Kagami K., Abe M., Nakane T., Goi K.,
RA   Inukai T., Saitoh S., Ohno S., Okazaki S., Nagano O., Saya H.,
RA   Sugita K.;
RT   "Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers
RT   necrosis of B-precursor leukemia cells with high surface CD44
RT   expression.";
RL   Cell Death Dis. 8:e2857.1-e2857.11(2017).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//