ID   MDA-Panc-3
AC   CVCL_3918
SY   MDA Panc-3; MDAPanc-3; MDAPanc3
DR   BTO; BTO:0003302
DR   cancercelllines; CVCL_3918
DR   Cosmic; 710860
DR   IARC_TP53; 16742
DR   Wikidata; Q54904651
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=1688394;
RX   PubMed=11169959;
RX   PubMed=11787853;
WW   https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/MDA%20Panc-3.html
CC   Doubling time: ~50 hours (PubMed=1688394).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=11169959; PubMed=11787853).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C8294; Pancreatic adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 18
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R.,
RA   Saeger H.-D.;
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=1688394; DOI=10.1097/00006676-199001000-00002;
RA   Frazier M.L., Pathak S., Wang Z.-W., Cleary K., Singletary S.E.,
RA   Olive M., Mackay B., Steck P.A., Levin B.;
RT   "Establishment of a new human pancreatic adenocarcinoma cell line,
RT   MDAPanc-3.";
RL   Pancreas 5:8-16(1990).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore P.S., Sipos B., Orlandini S., Sorio C., Real F.X., Lemoine N.R.,
RA   Gress T.M., Bassi C., Kloppel G., Kalthoff H., Ungefroren H.,
RA   Lohr J.-M., Scarpa A.;
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//