ID   A818-1
AC   CVCL_3891
AS   CVCL_8604
SY   A-818-1; A 818-1; A818.1; A818 1; 818-1; 818_1; 818.1
DR   cancercelllines; CVCL_3891
DR   Cosmic; 736266
DR   Cosmic; 808169
DR   Cosmic; 933524
DR   Wikidata; Q54607224
RX   PubMed=1764370;
RX   PubMed=1906154;
RX   PubMed=8426738;
RX   PubMed=8430098;
RX   PubMed=10415853;
RX   PubMed=11169959;
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/A818.html
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=11169959).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3890 ! A818
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874;
RA   Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C.,
RA   Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N.,
RA   Lane D.P., Lemoine N.R.;
RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
RL   Br. J. Cancer 64:1076-1082(1991).
//
RX   PubMed=1906154;
RA   Kalthoff H., Roeder C., Humburg I., Thiele H.-G., Greten H.,
RA   Schmiegel W.H.;
RT   "Modulation of platelet-derived growth factor A- and B-chain/c-sis
RT   mRNA by tumor necrosis factor and other agents in adenocarcinoma
RT   cells.";
RL   Oncogene 6:1015-1021(1991).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=8430098; DOI=10.1073/pnas.90.3.863; PMCID=PMC45770;
RA   Schmiegel W.H., Roeder C., Schmielau J., Rodeck U., Kalthoff H.;
RT   "Tumor necrosis factor alpha induces the expression of transforming
RT   growth factor alpha and the epidermal growth factor receptor in human
RT   pancreatic cancer cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:863-867(1993).
//
RX   PubMed=10415853; DOI=10.1111/j.1749-6632.1999.tb09512.x;
RA   Lehnert L., Trost H., Schmiegel W.H., Roeder C., Kalthoff H.;
RT   "Hollow-spheres: a new model for analyses of differentiation of
RT   pancreatic duct epithelial cells.";
RL   Ann. N. Y. Acad. Sci. 880:83-93(1999).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//