ID   SW1222
AC   CVCL_3886
SY   SW-1222; SW 1222
DR   BTO; BTO_0003105
DR   cancercelllines; CVCL_3886
DR   CancerTools; 152434
DR   ColonAtlas; SW1222
DR   Cosmic; 876714
DR   Cosmic; 948833
DR   Cosmic; 985653
DR   Cosmic; 986017
DR   Cosmic; 995398
DR   Cosmic; 1043827
DR   Cosmic; 1223148
DR   Cosmic; 1312313
DR   Cosmic; 1479605
DR   Cosmic; 1482523
DR   Cosmic; 1524330
DR   Cosmic; 1803950
DR   Cosmic; 2302013
DR   Cosmic; 2760073
DR   Cosmic; 2800578
DR   ECACC; 12022910
DR   GEO; GSM1346888
DR   GEO; GSM1374918
DR   GEO; GSM1448088
DR   GEO; GSM3145613
DR   GEO; GSM3145738
DR   IARC_TP53; 21761
DR   Wikidata; Q54971074
DR   Ximbio; 152434
RX   PubMed=286328;
RX   PubMed=924690;
RX   PubMed=1778766;
RX   PubMed=3518877;
RX   PubMed=6220172;
RX   PubMed=6582512;
RX   PubMed=8464898;
RX   PubMed=9294210;
RX   PubMed=10737795;
RX   PubMed=16418264;
RX   PubMed=20570890;
RX   PubMed=20606684;
RX   PubMed=24755471;
RX   PubMed=25926053;
CC   From: Scott and White Clinic; Temple; USA.
CC   HLA typing: A*01 (PubMed=8464898).
CC   Microsatellite instability: Stable (MSS) (PubMed=24755471; PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Glu1306Ter (c.3916G>T) (E1288*, c.3862G>T); ClinVar=VCV000376059; Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala146Val (c.437C>T); ClinVar=VCV000375962; Zygosity=Unspecified (PubMed=20570890).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Leu540Arg (c.1619T>G); Zygosity=Unspecified (PubMed=24755471).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex1 113 bp del; Zygosity=Unspecified (PubMed=16418264).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Discontinued: ECACC; 12022910; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ECACC=12022910; PubMed=25926053
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 9 (PubMed=25926053)
ST   D13S317: 9,13 (ECACC=12022910)
ST   D16S539: 9,10
ST   D21S11: 29
ST   D5S818: 9
ST   D7S820: 10,12
ST   TH01: 7
ST   TPOX: 10
ST   vWA: 18
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 35
//
RX   PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243;
RA   Rowan, Andrew J.
RA   Lamlum, Hanan
RA   Ilyas, Mohammad
RA   Wheeler, James M.D.
RA   Straub, Jannes
RA   Papadopoulou, Angeliki
RA   Bicknell, David C.
RA   Bodmer, Walter Fred
RA   Tomlinson, Ian Philip Mark
RT   "APC mutations in sporadic colorectal tumors: a mutational 'hotspot'
RT   and interdependence of the 'two hits'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
//
RX   PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013;
RA   Mouradov, Dmitri
RA   Sloggett, Clare
RA   Jorissen, Robert N.
RA   Love, Christopher G.
RA   Li, Shan
RA   Burgess, Antony Wilks
RA   Arango, Diego
RA   Strausberg, Robert L.
RA   Buchanan, Daniel
RA   Wormald, Samuel
RA   O'Connor, Liam
RA   Wilding, Jennifer L.
RA   Bicknell, David C.
RA   Tomlinson, Ian Philip Mark
RA   Bodmer, Walter Fred
RA   Mariadason, John M.
RA   Sieber, Oliver M.
RT   "Colorectal cancer cell lines are representative models of the main
RT   molecular subtypes of primary cancer.";
RL   Cancer Res. 74:3238-3247(2014).
//
RX   PubMed=6220172;
RA   Dracopoli, Nicholas C.
RA   Fogh, Jorgen
RT   "Polymorphic enzyme analysis of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 70:469-476(1983).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028;
RA   Bracht, Karin
RA   Nicholls, Angela M.
RA   Liu, Ying
RA   Bodmer, Walter Fred
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=286328; DOI=10.1073/pnas.76.3.1438; PMCID=PMC383267;
RA   Herlyn, Meenhard
RA   Steplewski, Zenon
RA   Herlyn, Dorothee
RA   Koprowski, Hilary
RT   "Colorectal carcinoma-specific antigen: detection by means of
RT   monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).
//
RX   PubMed=924690; DOI=10.1002/ijc.2910200505;
RA   Kerbel, Robert S.
RA   Pross, Hugh F.
RA   Leibovitz, Albert
RT   "Analysis of established human carcinoma cell lines for
RT   lymphoreticular-associated membrane receptors.";
RL   Int. J. Cancer 20:673-679(1977).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731;
RA   Liu, Ying
RA   Bodmer, Walter Fred
RT   "Analysis of p53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192;
RA   Browning, Michael J.
RA   Krausa, Peter
RA   Rowan, Andrew J.
RA   Bicknell, David C.
RA   Bodmer, Julia Gwynaeth
RA   Bodmer, Walter Fred
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514;
RA   Janakiraman, Manickam
RA   Vakiani, Efsevia
RA   Zeng, Zhao-Shi
RA   Pratilas, Christine A.
RA   Taylor, Barry Stephen
RA   Chitale, Dhananjay
RA   Halilovic, Ensar
RA   Wilson, Manda
RA   Huberman, Kety
RA   Ricarte Filho, Julio Cezar Marques
RA   Persaud, Yogindra
RA   Levine, Douglas A.
RA   Fagin, James Alexander
RA   Jhanwar, Suresh C.
RA   Mariadason, John M.
RA   Lash, Alex
RA   Ladanyi, Marc
RA   Saltz, Leonard B.
RA   Heguy, Adriana
RA   Paty, Philip B.
RA   Solit, David B.
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico, Enzo
RA   Russo, Mariangela
RA   Picco, Gabriele
RA   Cancelliere, Carlotta
RA   Valtorta, Emanuele
RA   Corti, Giorgio
RA   Buscarino, Michela
RA   Isella, Claudio
RA   Lamba, Simona
RA   Martinoglio, Barbara
RA   Veronese, Silvio
RA   Siena, Salvatore
RA   Sartore-Bianchi, Andrea
RA   Beccuti, Marco
RA   Mottolese, Marcella
RA   Linnebacher, Michael
RA   Cordero, Francesca
RA   Di Nicolantonio, Federica
RA   Bardelli, Alberto
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361;
RA   Takeshima, Eisuke
RA   Hamaguchi, Michinari
RA   Watanabe, Tadashi
RA   Akiyama, Seiji
RA   Kataoka, Masato
RA   Ohnishi, Yukano
RA   Xiao, Heng-Yi
RA   Nagai, Yoshiyuki
RA   Takagi, Hiroshi
RT   "Aberrant elevation of tyrosine-specific phosphorylation in human
RT   gastric cancer cells.";
RL   Jpn. J. Cancer Res. 82:1428-1435(1991).
//
RX   PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362;
RA   Ilyas, Mohammad
RA   Tomlinson, Ian Philip Mark
RA   Rowan, Andrew J.
RA   Pignatelli, Massimo
RA   Bodmer, Walter Fred
RT   "Beta-catenin mutations in cell lines established from human
RT   colorectal cancers.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//