ID   SW527
AC   CVCL_3799
SY   SW-527; SW 527
DR   CLO; CLO_0009219
DR   EFO; EFO_0005462
DR   ArrayExpress; E-MTAB-2706
DR   ATCC; CRL-7940
DR   BioSample; SAMN03151930
DR   BioSample; SAMN03481115
DR   cancercelllines; CVCL_3799
DR   Cosmic; 1047713
DR   DepMap; ACH-001825
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   LINCS_HMS; 50046
DR   LINCS_LDP; LCL-1474
DR   PharmacoDB; SW527_1526_2019
DR   PRIDE; PXD008222
DR   Wikidata; Q54971177
RX   PubMed=288927;
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=20143388;
RX   PubMed=22585861;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25892236;
RX   PubMed=26589293;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a SW480 derivative (PubMed=288927; PubMed=20143388). Originally thought to originate from a 70 year old female patient with a metastatic breast carcinoma.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   From: Scott and White Clinic; Temple; USA.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00089.
CC   Population: Caucasian.
CC   HLA typing: A*02:01,24:02; B*07:02,15:18; C*07:04,07:04; DQA1*01:02,01:02; DQB1*05:01,05:01; DRB1*01:03,15:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): ATCC=CRL-7940; DepMap=ACH-001825; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 13,14
ST   D13S317: 12
ST   D16S539: 9,13
ST   D18S51: 13
ST   D19S433: 13
ST   D21S11: 30,30.2
ST   D2S1338: 17,24
ST   D3S1358: 15,16
ST   D5S818: 13
ST   D7S820: 8
ST   D8S1179: 13
ST   FGA: 24
ST   Penta D: 9,15
ST   Penta E: 10
ST   TH01: 8
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0546 ! SW480
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25892236; DOI=10.1016/j.celrep.2015.03.050; PMCID=PMC4425736;
RA   Lawrence, Robert T.
RA   Perez, Elizabeth M.
RA   Hernandez, Daniel
RA   Miller, Chris P.
RA   Haas, Kelsey M.
RA   Irie, Hanna Y.
RA   Lee, Su-In
RA   Blau, C. Anthony
RA   Villen, Judit
RT   "The proteomic landscape of triple-negative breast cancer.";
RL   Cell Rep. 11:630-644(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh, Jorgen
RA   Fogh, Jens M.
RA   Orfeo, Thomas
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh, Jorgen
RA   Wright, William C.
RA   Loveless, James D.
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=288927; DOI=10.1093/jnci/63.3.635;
RA   Leibovitz, Albert
RA   Wright, William C.
RA   Pathak, Sen
RA   Siciliano, Michael Joseph
RA   Daniels, Walter P.
RA   Fogh, Helle
RA   Fogh, Jorgen
RT   "Detection and analysis of a glucose 6-phosphate dehydrogenase
RT   phenotype B cell line contamination.";
RL   J. Natl. Cancer Inst. 63:635-645(1979).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte, Richard
RA   Brown, Kevin R.
RA   Suarez Saiz, Fernando Jose
RA   Sayad, Azin
RA   Karamboulas, Konstantina
RA   Krzyzanowski, Paul M.
RA   Sircoulomb, Fabrice
RA   Medrano, Mauricio
RA   Fedyshyn, Yaroslav
RA   Koh, Judice Lie-Yong
RA   van Dyk, Dewald
RA   Fedyshyn, Bohdana
RA   Luhova, Marianna
RA   Brito, Glauber C.
RA   Vizeacoumar, Franco J.
RA   Vizeacoumar, Frederick S.
RA   Datti, Alessandro
RA   Kasimer, Dahlia
RA   Buzina, Alla
RA   Mero, Patricia
RA   Misquitta, Christine
RA   Normand, Josee
RA   Haider, Maliha
RA   Ketela, Troy
RA   Wrana, Jeffrey L.
RA   Rottapel, Robert
RA   Neel, Benjamin G.
RA   Moffat, Jason
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//