ID OVK18 AC CVCL_3770 SY OVK-18; OVK#18 DR CLO; CLO_0051452 DR EFO; EFO_0022631 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 495 DR BioSample; SAMN03472087 DR BioSample; SAMN10987740 DR cancercelllines; CVCL_3770 DR Cell_Model_Passport; SIDM00238 DR Cosmic; 1066216 DR Cosmic; 1708385 DR Cosmic-CLP; 1480371 DR DepMap; ACH-000947 DR EGA; EGAS00001000978 DR GDSC; 1480371 DR GEO; GSM887486 DR GEO; GSM888568 DR GEO; GSM1670322 DR IARC_TP53; 28375 DR LiGeA; CCLE_457 DR PharmacoDB; OVK18_1223_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_3770 DR RCB; RCB1903 DR TKG; TKG 0323 DR Wikidata; Q54937028 RX PubMed=6584390; RX PubMed=22460905; RX PubMed=22705003; RX PubMed=23839242; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30485824; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=32612269; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: ~48 hours (PubMed=6584390). CC HLA typing: A*24:02,24:02; B*15:01,54:01; C*01:02,04:01; DQA1*05:02,05:02; DRB1*13:07,15:01 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Leu437fs*1 (c.1305delT); Zygosity=Heterozygous (Cosmic-CLP=1480371; DepMap=ACH-000947). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala59Gly (c.176C>G); Zygosity=Heterozygous (Cosmic-CLP=1480371; DepMap=ACH-000947). CC Sequence variation: Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Tyr366fs*17 (c.1096delT); Zygosity=Heterozygous (Cosmic-CLP=1480371; DepMap=ACH-000947). CC Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Pro109fs*194 (c.322delC); Zygosity=Heterozygous (Cosmic-CLP=1480371; DepMap=ACH-000947). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Heterozygous (Cosmic-CLP=1480371; DepMap=ACH-000947). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=78.65%; East Asian, South=21.35%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373). CC Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. ST Source(s): Cosmic-CLP=1480371; PubMed=30485824; RCB=RCB1903; TKG=TKG 0323 ST Amelogenin: X ST CSF1PO: 10,11 ST D13S317: 8,12 ST D16S539: 9,11 ST D21S11: 30,31 ST D5S818: 8,13 ST D7S820: 8 (RCB=RCB1903) ST D7S820: 8,13,14 (Cosmic-CLP=1480371; PubMed=30485824; TKG=TKG 0323) ST TH01: 7 ST TPOX: 8,11 ST vWA: 17,18 DI NCIt; C7979; Ovarian endometrioid adenocarcinoma DI ORDO; Orphanet_454723; Endometrioid carcinoma of ovary OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 49Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 33 CH CVCL_7171 ! OVK18#102 // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=6584390; DOI=10.1016/0090-8258(84)90217-8; RA Uehara, Shigeki RA Abe, Hiroshi RA Hoshiai, Hiroshi RA Yajima, Akira RA Suzuki, Masakuni RT "Establishment and characterization of ovarian endometrioid carcinoma RT cell line."; RL Gynecol. Oncol. 17:314-325(1984). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945; RA Papp, Eniko RA Hallberg, Dorothy RA Konecny, Gottfried E. RA Bruhm, Daniel C. RA Adleff, Vilmos RA Noe, Michael RA Kagiampakis, Ioannis RA Palsgrove, Doreen RA Conklin, Dylan RA Kinose, Yasuto RA White, James R. RA Press, Michael F. RA Drapkin, Ronny I. RA Easwaran, Hariharan RA Baylin, Stephen Bruce RA Slamon, Dennis Joseph RA Velculescu, Victor E. RA Scharpf, Robert B. RT "Integrated genomic, epigenomic, and expression analyses of ovarian RT cancer cell lines."; RL Cell Rep. 25:2617-2633(2018). // RX PubMed=32612269; DOI=10.1038/s41598-020-67533-1; PMCID=PMC7329846; RA De Haven Brandon, Alexis Katherine RA Box, Gary RA Hallsworth, Albert RA Court, William RA Matthews, Nicoll RA Herodek, Balint RA Arteagabeitia, Aitor Bermejo RA Valenti, Melanie RA Kirkin, Vladimir RT "Identification of ovarian high-grade serous carcinoma cell lines that RT show estrogen-sensitive growth as xenografts in immunocompromised RT mice."; RL Sci. Rep. 10:10799.1-10799.13(2020). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011; RA Rahman, Munmun RA Nakayama, Kentaro RA Rahman, Mohammed Tanjimur RA Nakayama, Naomi RA Ishikawa, Masako RA Katagiri, Atsuko RA Iida, Kouji RA Nakayama, Satoru RA Otsuki, Yoshiro RA Shih, Ie-Ming RA Miyazaki, Kohji RT "Clinicopathologic and biological analysis of PIK3CA mutation in RT ovarian clear cell carcinoma."; RL Hum. Pathol. 43:2197-2206(2012). // RX PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866; RA Domcke, Silvia RA Sinha, Rileen RA Levine, Douglas A. RA Sander, Chris RA Schultz, Nikolaus RT "Evaluating cell lines as tumour models by comparison of genomic RT profiles."; RL Nat. Commun. 4:2126.1-2126.10(2013). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). //