ID   MCF-12A
AC   CVCL_3744
SY   MCF12A; Michigan Cancer Foundation-12A
DR   BTO; BTO_0002544
DR   CLO; CLO_0007603
DR   CLO; CLO_0037180
DR   EFO; EFO_0001202
DR   ArrayExpress; E-TABM-157
DR   ArrayExpress; E-TABM-244
DR   ATCC; CRL-3598
DR   ATCC; CRL-10782
DR   BioSample; SAMN03472816
DR   ChEMBL-Cells; CHEMBL3307365
DR   ChEMBL-Targets; CHEMBL614322
DR   Cosmic; 1017163
DR   Cosmic; 1136378
DR   Cosmic; 1176637
DR   Cosmic; 2560249
DR   DepMap; ACH-002327
DR   GEO; GSM756372
DR   GEO; GSM844585
DR   GEO; GSM845396
DR   GEO; GSM1053717
DR   GEO; GSM1172884
DR   GEO; GSM1172975
DR   GEO; GSM1238117
DR   LINCS_HMS; 51089
DR   LINCS_LDP; LCL-2082
DR   PharmacoDB; MCF12A_894_2019
DR   PRIDE; PXD005339
DR   PubChem_Cell_line; CVCL_3744
DR   TOKU-E; 2381
DR   Wikidata; Q54904301
RX   Patent=US5206165;
RX   PubMed=17157791;
RX   PubMed=18516279;
RX   PubMed=24094812;
RX   PubMed=24162158;
RX   PubMed=24176112;
RX   PubMed=25960936;
RX   PubMed=28287265;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/normal-morphology-of-the-crl-10782-mcf-12a-cells
WW   Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Group: Patented cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: ICBP43 breast cancer cell line panel.
CC   Part of: JWGray breast cancer cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10782.
CC   Population: Caucasian.
CC   Doubling time: ~19 hours (ATCC=CRL-3598); 35.42 hours (JWGray panel).
CC   HLA typing: A*66:01,02:01; B*41:02,18:01/35:08; C*07:01,17:01; DRB1*11:67,11:67 (PubMed=25960936).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; PTM; Glycoproteome.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; CRL-10782; true.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
ST   Source(s): ATCC=CRL-3598
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,11
ST   D16S539: 9,12
ST   D18S51: 18
ST   D19S433: 13,15
ST   D21S11: 28,30
ST   D2S1338: 19
ST   D3S1358: 16,18
ST   D5S818: 11,13
ST   D7S820: 8,11
ST   D8S1179: 10,13
ST   FGA: 23,26
ST   Penta D: 9,12
ST   Penta E: 7,10
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_3745 ! MCF-12F
SX   Female
AG   63Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776;
RA   Prat, Aleix
RA   Karginova, Olga
RA   Parker, Joel S.
RA   Fan, Cheng
RA   He, Xia-Ping
RA   Bixby, Lisa M.
RA   Harrell, J. Chuck
RA   Roman, Erick
RA   Adamo, Barbara
RA   Troester, Melissa A.
RA   Perou, Charles M.
RT   "Characterization of cell lines derived from breast cancers and normal
RT   mammary tissues for the study of the intrinsic molecular subtypes.";
RL   Breast Cancer Res. Treat. 142:237-255(2013).
//
RX   PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310;
RA   Timmerman, Luika A.
RA   Holton, Thomas
RA   Yuneva, Mariia
RA   Louie, Raymond J.
RA   Padro, Merce
RA   Daemen, Anneleen
RA   Hu, Min
RA   Chan, Denise A.
RA   Ethier, Stephen P.
RA   van 't Veer, Laura J.
RA   Polyak, Kornelia
RA   McCormick, Frank
RA   Gray, Joe W.
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005;
RA   Kenny, Paraic A.
RA   Lee, Genee Y.
RA   Myers, Connie A.
RA   Neve, Richard M.
RA   Semeiks, Jeremy R.
RA   Spellman, Paul T.
RA   Lorenz, Kristina
RA   Lee, Eva H.
RA   Barcellos-Hoff, Mary Helen
RA   Petersen, Ole William
RA   Gray, Joe W.
RA   Bissell, Mina J.
RT   "The morphologies of breast cancer cell lines in three-dimensional
RT   assays correlate with their profiles of gene expression.";
RL   Mol. Oncol. 1:84-96(2007).
//
RX   PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470; PMCID=PMC5557415;
RA   Yen, Ten-Yang
RA   Bowen, Spencer
RA   Yen, Roger
RA   Piryatinska, Alexandra
RA   Macher, Bruce A.
RA   Timpe, Leslie C.
RT   "Glycoproteins in claudin-low breast cancer cell lines have a unique
RT   expression profile.";
RL   J. Proteome Res. 16:1391-1400(2017).
//
RX   Patent=US5206165;
RA   Pauley, Robert J.
RA   Paine, Terry J.
RA   Soule, Herbert D.
RT   "Immortal human mammary epithelial cell sublines.";
RL   Patent number US5206165, 27-Apr-1993.
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//