ID   EW-2
AC   CVCL_3446
SY   EW2; IARC-EW2; IARC-EW-2; IARC-EW 2
DR   cancercelllines; CVCL_3446
DR   Cell_Model_Passport; SIDM00204
DR   Cosmic; 1388895
DR   Cosmic; 2228228
DR   Cosmic; 2804870
DR   IARC_TP53; 706
DR   Wikidata; Q54832998
RX   PubMed=6713356;
RX   PubMed=8108117;
RX   PubMed=8378080;
RX   PubMed=25010205;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=8378080).
CC   Derived from site: Metastatic; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): PubMed=25010205
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 13,14
ST   D16S539: 12
ST   D18S51: 11,12
ST   D19S433: 13,14
ST   D21S11: 31.2,32.2
ST   D2S1338: 17,23
ST   D3S1358: 17
ST   D5S818: 15
ST   D7S820: 11,12
ST   D8S1179: 13
ST   FGA: 22,26
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 19
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1208 ! EW-1
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=6713356; DOI=10.1016/0165-4608(84)90002-5;
RA   Turc-Carel C., Philip I., Berger M.-P., Philip T., Lenoir G.M.;
RT   "Chromosome study of Ewing's sarcoma (ES) cell lines. Consistency of a
RT   reciprocal translocation t(11;22)(q24;q12).";
RL   Cancer Genet. Cytogenet. 12:1-19(1984).
//
RX   PubMed=8108117;
RA   Albert T., Urlbauer B., Kohlhuber F., Hammersen B., Eick D.;
RT   "Ongoing mutations in the N-terminal domain of c-Myc affect
RT   transactivation in Burkitt's lymphoma cell lines.";
RL   Oncogene 9:759-763(1994).
//
RX   PubMed=8378080;
RA   Kovar H., Auinger A., Jug G., Aryee D.N.T., Zoubek A.,
RA   Salzer-Kuntschik M., Gadner H.;
RT   "Narrow spectrum of infrequent p53 mutations and absence of MDM2
RT   amplification in Ewing tumours.";
RL   Oncogene 8:2683-2690(1993).
//
RX   PubMed=25010205; DOI=10.1371/journal.pgen.1004475;
RA   Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S.,
RA   Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y.,
RA   Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H.,
RA   Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S.,
RA   Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.;
RT   "The genomic landscape of the Ewing sarcoma family of tumors reveals
RT   recurrent STAG2 mutation.";
RL   PLoS Genet. 10:E1004475-E1004475(2014).
//