ID   U87/DK
AC   CVCL_3428
SY   U87-DK; U87DK; U87 dead kinase; U87MG.deltaEGFR DK; U87MG.DK
DR   CLDB; cl7208
DR   cancercelllines; CVCL_3428
DR   ICLC; HTL08003
DR   Wikidata; Q54973750
RX   PubMed=8810340;
RX   PubMed=9006938;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 3236; EGFR (with p.Val30_Arg297del and pLys745Met = EGFRvIII and dead kinase).
ST   Source(s): ICLC=HTL08003
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 12
ST   D21S11: 28.2,32.2
ST   D5S818: 11,12
ST   D7S820: 8,9
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 20
RX   PubMed=8810340; DOI=10.1074/jbc.271.41.25639;
RA   Prigent S.A., Nagane M., Lin H., Huvar I., Boss G.R., Feramisco J.R.,
RA   Cavenee W.K., Huang H.-J.S.;
RT   "Enhanced tumorigenic behavior of glioblastoma cells expressing a
RT   truncated epidermal growth factor receptor is mediated through the
RT   Ras-Shc-Grb2 pathway.";
RL   J. Biol. Chem. 271:25639-25645(1996).
RX   PubMed=9006938; DOI=10.1074/jbc.272.5.2927;
RA   Huang H.-J.S., Nagane M., Klingbeil C.K., Lin H., Nishikawa R.,
RA   Ji X.-D., Huang C.-M., Gill G.N., Wiley H.S., Cavenee W.K.;
RT   "The enhanced tumorigenic activity of a mutant epidermal growth factor
RT   receptor common in human cancers is mediated by threshold levels of
RT   constitutive tyrosine phosphorylation and unattenuated signaling.";
RL   J. Biol. Chem. 272:2927-2935(1997).