ID   SUM52PE
AC   CVCL_3425
SY   SUM-52PE; SUM 52PE; SUM-52-PE; SUM-52; SUM 52; SUM52; 52PE
DR   BTO; BTO_0005390
DR   CLO; CLO_0037189
DR   EFO; EFO_0001246
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-TABM-157
DR   BioSample; SAMN03472911
DR   cancercelllines; CVCL_3425
DR   Cell_Model_Passport; SIDM01422
DR   Cosmic; 904387
DR   Cosmic; 1046962
DR   Cosmic; 1176647
DR   Cosmic; 1287897
DR   Cosmic; 1289409
DR   Cosmic; 1460238
DR   DepMap; ACH-001396
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001002554
DR   GEO; GSM115109
DR   GEO; GSM217604
DR   GEO; GSM219890
DR   GEO; GSM320178
DR   GEO; GSM350524
DR   GEO; GSM421887
DR   GEO; GSM481330
DR   GEO; GSM844711
DR   GEO; GSM844712
DR   GEO; GSM847439
DR   GEO; GSM847506
DR   GEO; GSM1053739
DR   GEO; GSM1172903
DR   GEO; GSM1172998
DR   GEO; GSM1374912
DR   IARC_TP53; 24366
DR   LINCS_HMS; 51087
DR   LINCS_LDP; LCL-2071
DR   Lonza; 1253
DR   PharmacoDB; SUM52PE_1513_2019
DR   Progenetix; CVCL_3425
DR   SLKBase; 231
DR   Wikidata; Q54970851
RX   PubMed=10424408;
RX   PubMed=10604729;
RX   PubMed=10969801;
RX   PubMed=12800145;
RX   PubMed=15677628;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=17157791;
RX   PubMed=19582160;
RX   PubMed=19593635;
RX   PubMed=21778573;
RX   PubMed=23401782;
RX   PubMed=23601657;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26589293;
RX   PubMed=26759240;
RX   PubMed=32715085;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=SUM-52PE
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/SUM52.html
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   Provider; BioIVT/Asterand; -; https://bioivt.com/sum-breast-cancer-cell-lines/
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Doubling time: 55.21 hours (JWGray panel).
CC   HLA typing: A*32:01,32:01; B*07:02,15:01; C*03:03,07:02; DQB1*06:04,05:01; DRB1*15:01,15:01 (PubMed=25960936).
CC   HLA typing: A*32:01,32:01; B*07:02,15:01; C*03:03,07:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68Val (c.203C>T); ClinVar=VCV000406701; Zygosity=Homozygous (PubMed=19593635; DepMap=ACH-001396).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (PubMed=16541312; DepMap=ACH-001396).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DepMap=ACH-001396; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 12
ST   D16S539: 10
ST   D18S51: 16
ST   D21S11: 27,28
ST   D3S1358: 18
ST   D5S818: 11,12
ST   D7S820: 12,14 (DepMap=ACH-001396)
ST   D7S820: 14 (PubMed=25877200)
ST   D8S1179: 13
ST   FGA: 21 (PubMed=25877200)
ST   FGA: 21,22 (DepMap=ACH-001396)
ST   Penta D: 9,12
ST   Penta E: 13,17
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 40
CH   CVCL_A1FM ! SUM52PE GDC-0941_resistant
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide, Jose
RA   Huang, Huai-En
RA   Murati, Anne
RA   Alsop, Amber E.
RA   Orsetti, Beatrice
RA   Mozziconacci, Marie-Joelle
RA   Popovici, Cornel
RA   Ginestier, Christophe
RA   Letessier, Anne
RA   Basset, Celine
RA   Courtay-Cahen, Celine
RA   Jacquemier, Jocelyne
RA   Theillet, Charles
RA   Birnbaum, Daniel
RA   Edwards, Paul A.W.
RA   Chaffanet, Max
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890;
RA   Chavez, Kathryn J.
RA   Garimella, Sireesha Venkata
RA   Lipkowitz, Stanley
RT   "Triple negative breast cancer cell lines: one tool in the search for
RT   better treatment of triple negative breast cancer.";
RL   Breast Dis. 32:35-48(2010).
//
RX   PubMed=23401782; DOI=10.1155/2013/872743; PMCID=PMC3562669;
RA   Barnabas, Nandita
RA   Cohen, Dalia
RT   "Phenotypic and molecular characterization of MCF10DCIS and SUM breast
RT   cancer cell lines.";
RL   Int. J. Breast Cancer 2013:872743.1-872743.16(2013).
//
RX   PubMed=10604729; DOI=10.1038/sj.bjc.6695007; PMCID=PMC2362964;
RA   Forozan, Farahnaz
RA   Veldman, Robin
RA   Ammerman, Cheryl A.
RA   Parsa, Nasser Z.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RA   Ethier, Stephen P.
RT   "Molecular cytogenetic analysis of 11 new breast cancer cell lines.";
RL   Br. J. Cancer 81:1328-1334(1999).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Pharoah, Paul D.P.
RA   Staines, Joanne M.
RA   Oliveira, Carla
RA   Edwards, Paul A.W.
RA   Caldas, Carlos
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661;
RA   Riaz, Muhammad
RA   van Jaarsveld, Marijn T.M.
RA   Hollestelle, Antoinette
RA   Prager-van der Smissen, Wendy J.C.
RA   Heine, Anouk A.J.
RA   Boersma, Antonius W.M.
RA   Liu, Jing-Jing
RA   Helmijr, Jean C.A.
RA   Ozturk, Bahar
RA   Smid, Marcel
RA   Wiemer, Erik A.C.
RA   Foekens, John A.
RA   Martens, John W.M.
RT   "miRNA expression profiling of 51 human breast cancer cell lines
RT   reveals subtype and driver mutation-specific miRNAs.";
RL   Breast Cancer Res. 15:R33.1-R33.17(2013).
//
RX   PubMed=10969801;
RA   Forozan, Farahnaz
RA   Mahlamaki, Eija H.
RA   Monni, Outi
RA   Chen, Yi-Dong
RA   Veldman, Robin
RA   Jiang, Yuan
RA   Gooden, Gerald C.
RA   Ethier, Stephen P.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RT   "Comparative genomic hybridization analysis of 38 breast cancer cell
RT   lines: a basis for interpreting complementary DNA microarray data.";
RL   Cancer Res. 60:4519-4525(2000).
//
RX   PubMed=10424408; DOI=10.1023/A:1006135331912;
RA   Woods Ignatoski, Kathleen M.
RA   Ethier, Stephen P.
RT   "Constitutive activation of pp125fak in newly isolated human breast
RT   cancer cell lines.";
RL   Breast Cancer Res. Treat. 54:173-182(1999).
//
RX   PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084;
RA   Kao, Jessica
RA   Salari, Keyan
RA   Bocanegra, Melanie
RA   Choi, Yoon-La
RA   Girard, Luc
RA   Gandhi, Jeet
RA   Kwei, Kevin A.
RA   Hernandez-Boussard, Tina
RA   Wang, Pei
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Pollack, Jonathan R.
RT   "Molecular profiling of breast cancer cell lines defines relevant
RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:e6146.1-e6146.16(2009).
//
RX   PubMed=16541312; DOI=10.1007/s10549-006-9186-z;
RA   Wasielewski, Marijke
RA   Elstrodt, Fons
RA   Klijn, Jan G.M.
RA   Berns, Els M.J.J.
RA   Schutte, Mieke
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
RA   Elstrodt, Fons
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Gorin, Michael
RA   Wasielewski, Marijke
RA   van den Ouweland, Ans M.W.
RA   Merajver, Sofia Diana
RA   Ethier, Stephen P.
RA   Schutte, Mieke
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
RX   PubMed=32715085; DOI=10.1038/s41523-020-0173-z; PMCID=PMC7374090;
RA   Ethier, Stephen P.
RA   Guest, Stephen T.
RA   Garrett-Mayer, Elizabeth
RA   Armeson, Kent
RA   Wilson, Robert C.
RA   Duchinski, Kathryn
RA   Couch, Daniel
RA   Gray, Joe W.
RA   Kappler, Christiana S.
RT   "Development and implementation of the SUM breast cancer cell line
RT   functional genomics knowledge base.";
RL   NPJ Breast Cancer 6:30.1-30.14(2020).
//
RX   PubMed=19593635; DOI=10.1007/s10549-009-0460-8;
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Smid, Marcel
RA   Lam, Suzanne
RA   Elstrodt, Fons
RA   Wasielewski, Marijke
RA   Ng, Ser Sue
RA   French, Pim J.
RA   Peeters, Justine K.
RA   Rozendaal, Marieke J.
RA   Riaz, Muhammad
RA   Koopman, Daphne G.
RA   ten Hagen, Timo L.M.
RA   de Leeuw, Bertie H.C.G.M.
RA   Zwarthoff, Ellen C.
RA   Teunisse, Amina F.A.S.
RA   van der Spek, Peter J.
RA   Klijn, Jan G.M.
RA   Dinjens, Winand N.M.
RA   Ethier, Stephen P.
RA   Clevers, Hans Cornelius
RA   Jochemsen, Aart G.
RA   den Bakker, Michael A.
RA   Foekens, John A.
RA   Martens, John W.M.
RA   Schutte, Mieke
RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//
RX   PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201;
RA   Nakanishi, Yoshito
RA   Walter, Kimberly
RA   Spoerke, Jill M.
RA   O'Brien, Carol
RA   Huw, Ling Y.
RA   Hampton, Garret M.
RA   Lackner, Mark R.
RT   "Activating mutations in PIK3CB confer resistance to PI3K inhibition
RT   and define a novel oncogenic role for p110beta.";
RL   Cancer Res. 76:1193-1203(2016).
//