ID   SKN
AC   CVCL_3167
DR   CLO; CLO_0050881
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03470820
DR   BioSample; SAMN03472277
DR   cancercelllines; CVCL_3167
DR   Cell_Model_Passport; SIDM00377
DR   Cosmic; 1330908
DR   Cosmic-CLP; 1240215
DR   DepMap; ACH-001655
DR   EGA; EGAS00001000978
DR   GDSC; 1240215
DR   GEO; GSM827211
DR   GEO; GSM1670447
DR   JCRB; FDSC0031
DR   JCRB; IFO50314
DR   JCRB; JCRB0173
DR   PharmacoDB; SKN_1419_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_3167
DR   RCB; RCB0513
DR   Wikidata; Q54954754
RX   CelloPub=CLPUB00481;
RX   PubMed=556976;
RX   PubMed=2429643;
RX   PubMed=2448191;
RX   PubMed=9436037;
RX   PubMed=9573483;
RX   PubMed=10457904;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 36 hours (Note=At 29th passage) (PubMed=556976).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.3%; Native American=0%; East Asian, North=0%; East Asian, South=87.84%; South Asian=7.96%; European, North=0%; European, South=3.89% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0031; true.
ST   Source(s): Cosmic-CLP=1240215; DepMap=ACH-001655; JCRB=IFO50314; JCRB=JCRB0173; RCB=RCB0513
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 9
ST   D18S51: 13,15
ST   D21S11: 31.2
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 8,12
ST   D8S1179: 13,15
ST   FGA: 22
ST   Penta D: 9
ST   Penta E: 5
ST   TH01: 8
ST   TPOX: 8
ST   vWA: 19
DI   NCIt; C6340; Uterine corpus leiomyosarcoma
DI   ORDO; Orphanet_213625; Leiomyosarcoma of the corpus uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=10457904;
RA   Ishiwata, Isamu
RA   Sudo, Tadashi
RA   Kiguchi, Kazushige
RA   Ishikawa, Hiroshi
RT   "Tumor angiogenesis factors produced by cancer cells.";
RL   Hum. Cell 12:37-46(1999).
//
RX   CelloPub=CLPUB00481;
RA   Kuno, Haruhiko
RA   Yoshida, Touho
RT   "Detection of human papillomavirus types 16, 18, and 33 in cell lines
RT   derived from human genital organs by polymerase chain reaction.";
RL   Res. Commun. Inst. Ferment. 18:6-12(1997).
//
RX   PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5;
RA   Ishiwata, Isamu
RA   Ishiwata, Chieko
RA   Soma, Masayuki
RA   Ono, Isao
RA   Nakaguchi, Takenori
RA   Ishikawa, Hiroshi
RT   "Tumor angiogenic activity of gynecologic tumor cell lines on the
RT   chorioallantoic membrane.";
RL   Gynecol. Oncol. 29:87-93(1988).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=9573483;
RA   Ishiwata, Isamu
RA   Tokieda, Yuko
RA   Ishiwata, Chieko
RA   Okane, Natsumi
RA   Iguchi, Megumi
RA   Sato, Kahei
RA   Ishikawa, Hiroshi
RT   "Effects of feeder cells (human cancer cell lines) on the development
RT   of mouse embryos by co-culture.";
RL   Hum. Cell 10:237-246(1997).
//
RX   PubMed=9436037;
RA   Soma, Masayuki
RA   Ishiwata, Isamu
RA   Ishiwata, Chieko
RA   Nakaguchi, Takenori
RA   Ono, Isao
RA   Kiguchi, Kazushige
RA   Hashimoto, Hisashi
RA   Tachibana, Toshiaki
RA   Ishikawa, Hiroshi
RA   Nozawa, Shiro
RT   "Tissue reconstruction of gynecologic tumor cells in the rotation
RT   culture system.";
RL   Hum. Cell 10:175-181(1997).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x;
RA   Ishiwata, Isamu
RA   Ishiwata, Chieko
RA   Nozawa, Shiro
RA   Ishikawa, Hiroshi
RT   "CA125 production by gynecologic tumors in vitro and its modulation
RT   induced by dibutyl cyclic adenosine monophosphate.";
RL   Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986).
//
RX   PubMed=556976;
RA   Ishiwata, Isamu
RA   Nozawa, Shiro
RA   Nagai, Soichiro
RA   Kurihara, Soju
RA   Mikata, Atsuo
RA   Okumura, Hideo
RT   "Establishment of a human leiomyosarcoma cell line.";
RL   Cancer Res. 37:658-664(1977).
//