ID   RERF-LC-OK
AC   CVCL_3154
SY   RERF-LCOK; RERFLCOK; LC-OK; LCOK; Radiation Effects Research Foundation-Lung Cancer-OK
DR   EFO; EFO_0006744
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03151836
DR   BioSample; SAMN03471743
DR   cancercelllines; CVCL_3154
DR   Cell_Model_Passport; SIDM00385
DR   CGH-DB; 207-1
DR   CGH-DB; 9167-4
DR   Cosmic; 753609
DR   Cosmic; 801580
DR   Cosmic; 876139
DR   Cosmic; 889096
DR   Cosmic; 917974
DR   Cosmic; 932927
DR   Cosmic; 934469
DR   Cosmic; 946065
DR   Cosmic; 1066168
DR   Cosmic; 1219088
DR   Cosmic; 1239899
DR   Cosmic; 1571720
DR   Cosmic; 2125286
DR   Cosmic; 2668321
DR   EGA; EGAS00001000610
DR   GEO; GSM274667
DR   IARC_TP53; 11873
DR   IARC_TP53; 28443
DR   JCRB; JCRB0811
DR   PharmacoDB; RERFLCOK_1307_2019
DR   Wikidata; Q54949775
RX   PubMed=7834619;
RX   PubMed=9290701;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=14581340;
RX   PubMed=15185009;
RX   PubMed=15746151;
RX   PubMed=16105816;
RX   PubMed=19472407;
RX   PubMed=20143388;
RX   PubMed=20557307;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; JCRB; -; https://cellbank.nibiohn.go.jp/legacy/cellbank/qualitycontrol/identification/summary.htm
CC   Problematic cell line: Contaminated. Shown to be a Marcus derivative (PubMed=20143388). Originally thought to originate from a lung adenocarcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00344.
CC   Population: Caucasian.
CC   HLA typing: A*03:02,24:02; B*08:01,35:08; C*03:03,07:01; DRB1*04:22,04:22 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Phe113Cys (c.338T>G); ClinVar=VCV000634690; Zygosity=Unspecified (PubMed=10536175; PubMed=20557307).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Misspelling: PERF-LC-OK; Cosmic=2125286.
CC   Misspelling: REAF-LC-OK; Cosmic=1571720.
CC   Misspelling: RERF-LOCK; IARC_TP53=11873; PubMed=10536175.
CC   Discontinued: JCRB; JCRB0811; true.
ST   Source(s): JCRB=JCRB0811; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12,15
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 15
ST   D21S11: 29
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 9,11
ST   D8S1179: 13,14
ST   FGA: 20
ST   Penta D: 15
ST   Penta E: 12,20
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 17
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3019 ! Marcus
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846;
RA   Blanco, Raquel
RA   Iwakawa, Reika
RA   Tang, Mo-Ying
RA   Kohno, Takashi
RA   Angulo, Barbara
RA   Pio, Ruben
RA   Montuenga, Luis M.
RA   Minna, John D.
RA   Yokota, Jun
RA   Sanchez-Cespedes, Montse
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=14581340;
RA   Yokoi, Sana
RA   Yasui, Kohichiroh
RA   Iizasa, Toshihiko
RA   Imoto, Issei
RA   Fujisawa, Takehiko
RA   Inazawa, Johji
RT   "TERC identified as a probable target within the 3q26 amplicon that is
RT   detected frequently in non-small cell lung cancers.";
RL   Clin. Cancer Res. 9:4705-4713(2003).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680;
RA   Iwakawa, Reika
RA   Kohno, Takashi
RA   Enari, Masatoshi
RA   Kiyono, Tohru
RA   Yokota, Jun
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia, Li-Qun
RA   Osada, Motonobu
RA   Ishioka, Chikashi
RA   Gamo, Makio
RA   Ikawa, Shuntaro
RA   Suzuki, Takao
RA   Shimodaira, Hideki
RA   Niitani, Tomohito
RA   Kudo, Toshio
RA   Akiyama, Mitoshi
RA   Kimura, Narimiti
RA   Matsuo, Mitsuyoshi
RA   Mizusawa, Hiroshi
RA   Tanaka, Noriho
RA   Koyama, Hideki
RA   Namba, Masayoshi
RA   Kanamaru, Ryunosuke
RA   Kuroki, Toshio
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai, Yoshiaki
RA   Miyazawa, Hitoshi
RA   No_last_name, Huqun
RA   Tanaka, Tomoaki
RA   Udagawa, Kiyoshi
RA   Kato, Motoyasu
RA   Fukuyama, Shunichiro
RA   Yokote, Akemi
RA   Kobayashi, Kunihiko
RA   Kanazawa, Minoru
RA   Hagiwara, Koichi
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254;
RA   Yamaji, Haruko
RA   Iizasa, Toshihiko
RA   Koh, Eitetsu
RA   Suzuki, Makoto
RA   Otsuji, Mizuto
RA   Chang, Hao
RA   Motohashi, Shinichiro
RA   Yokoi, Sana
RA   Hiroshima, Kenzo
RA   Tagawa, Masatoshi
RA   Nakayama, Toshinori
RA   Fujisawa, Takehiko
RT   "Correlation between interleukin 6 production and tumor proliferation
RT   in non-small cell lung cancer.";
RL   Cancer Immunol. Immunother. 53:786-792(2004).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293;
RA   Kohno, Takashi
RA   Sato, Takako
RA   Takakura, Satoshi
RA   Takei, Kimiko
RA   Inoue, Kaoru
RA   Nishioka, Michiho
RA   Yokota, Jun
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita, Takeshi
RA   Kiyama, Masaharu
RA   Tomizawa, Yoshio
RA   Kohno, Takashi
RA   Yokota, Jun
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=15746151; DOI=10.1093/hmg/ddi092;
RA   Izumi, Hiroto
RA   Inoue, Jun
RA   Yokoi, Sana
RA   Hosoda, Hiroshi
RA   Shibata, Tatsuhiro
RA   Sunamori, Makoto
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RA   Imoto, Issei
RT   "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in
RT   non-small cell lung cancers.";
RL   Hum. Mol. Genet. 14:997-1007(2005).
//
RX   PubMed=7834619;
RA   Washimi, Osuke
RA   Nagatake, Masaaki
RA   Osada, Hirotaka
RA   Ueda, Ryuzo
RA   Koshikawa, Takashi
RA   Seki, Tsuneo
RA   Takahashi, Toshitada
RA   Takahashi, Takashi
RT   "In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations
RT   preferentially in non-small cell lung cancers.";
RL   Cancer Res. 55:514-517(1995).
//