ID   RERF-LC-MA
AC   CVCL_3153
SY   RERF-LCMA; LC-MA; LCMA; Radiation Effects Research Foundation-Lung Cancer-MA; Matsushima
DR   CLO; CLO_0037038
DR   BioSample; SAMN03151921
DR   BioSample; SAMN03472512
DR   cancercelllines; CVCL_3153
DR   Cell_Model_Passport; SIDM01152
DR   Cosmic; 713883
DR   Cosmic; 801613
DR   Cosmic; 876160
DR   Cosmic; 929152
DR   GEO; GSM827581
DR   IARC_TP53; 2386
DR   JCRB; JCRB0812
DR   LINCS_LDP; LCL-1820
DR   Progenetix; CVCL_3153
DR   Wikidata; Q54949771
RX   PubMed=8263009;
RX   PubMed=9290701;
RX   PubMed=9673367;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=20215515;
RX   PubMed=23136038;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a SK-MES-1 derivative (PubMed=23136038). Originally thought to originate from a small cell lung carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00386.
CC   Population: Caucasian.
CC   Doubling time: ~1.5 days (Note=Lot 01252008) (JCRB=JCRB0812).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Homozygous (PubMed=8263009; PubMed=10536175).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): JCRB=JCRB0812
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11
ST   D16S539: 13,14
ST   D5S818: 11
ST   D7S820: 8
ST   TH01: 6,10
ST   TPOX: 8
ST   vWA: 14
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0630 ! SK-MES-1
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293;
RA   Kohno, Takashi
RA   Sato, Takako
RA   Takakura, Satoshi
RA   Takei, Kimiko
RA   Inoue, Kaoru
RA   Nishioka, Michiho
RA   Yokota, Jun
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia, Li-Qun
RA   Osada, Motonobu
RA   Ishioka, Chikashi
RA   Gamo, Makio
RA   Ikawa, Shuntaro
RA   Suzuki, Takao
RA   Shimodaira, Hideki
RA   Niitani, Tomohito
RA   Kudo, Toshio
RA   Akiyama, Mitoshi
RA   Kimura, Narimiti
RA   Matsuo, Mitsuyoshi
RA   Mizusawa, Hiroshi
RA   Tanaka, Noriho
RA   Koyama, Hideki
RA   Namba, Masayoshi
RA   Kanamaru, Ryunosuke
RA   Kuroki, Toshio
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=9673367;
RA   Fujishita, Takashi
RA   Mizushima, Yutaka
RA   Kashii, Tatsuhiko
RA   Kobayashi, Masashi
RT   "Coincidental alterations of p16INK4A/CDKN2 and other genes in human
RT   lung cancer cell lines.";
RL   Anticancer Res. 18:1537-1542(1998).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita, Takeshi
RA   Kiyama, Masaharu
RA   Tomizawa, Yoshio
RA   Kohno, Takashi
RA   Yokota, Jun
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=23136038; DOI=10.1002/ijc.27931;
RA   Capes-Davis, Amanda
RA   Reid, Yvonne A.
RA   Kline, Margaret C.
RA   Storts, Douglas R.
RA   Strauss, Ethan
RA   Dirks, Wilhelm Gerhard
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Sykes, Gregory R.
RA   Kohara, Arihiro
RA   Nakamura, Yukio
RA   Elmore, Eugene
RA   Nims, Raymond Whiting
RA   Alston-Roberts, Christine
RA   Barallon, Rita
RA   Los, Georgyi V.
RA   Nardone, Roland Mario
RA   Price, Paul J.
RA   Steuer, Anton
RA   Thomson, Jim A.
RA   Masters, John R.W.
RA   Kerrigan, Liz
RT   "Match criteria for human cell line authentication: where do we draw
RT   the line?";
RL   Int. J. Cancer 132:2510-2519(2013).
//
RX   PubMed=8263009; DOI=10.1007/BF01202192;
RA   Kashii, Tatsuhiko
RA   Mizushima, Yutaka
RA   Monno, Satoshi
RA   Nakagawa, Keiko
RA   Kobayashi, Masashi
RT   "Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility
RT   genes in human lung cancer cell lines by the polymerase chain
RT   reaction/single-strand conformation polymorphism method.";
RL   J. Cancer Res. Clin. Oncol. 120:143-148(1994).
//