ID   OZ [Human cholangiocarcinoma]
AC   CVCL_3118
DR   BioSample; SAMN03472539
DR   Cosmic; 1122353
DR   Cosmic; 1373552
DR   Cosmic; 2629291
DR   Cosmic; 2674046
DR   JCRB; JCRB1032
DR   JCRB; NIHS0282
DR   Wikidata; Q54937185
RX   CelloPub=CLPUB00275;
RX   CelloPub=CLPUB00469;
RX   PubMed=2889643;
RX   PubMed=21451941;
RX   PubMed=26956050;
RX   PubMed=32899426;
RX   PubMed=35640676;
RX   PubMed=39026794;
CC   Part of: Biliary tract cancer cell line atlas.
CC   Population: Japanese.
CC   Doubling time: ~48 hours (CelloPub=CLPUB00469; PubMed=2889643).
CC   Omics: Transcriptomics; RNAseq.
CC   Discontinued: JCRB; NIHS0282; true.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): JCRB=JCRB1032
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,12
ST   D16S539: 10
ST   D5S818: 13,14
ST   D7S820: 10
ST   TH01: 6,9
ST   TPOX: 9,11
ST   vWA: 14,16
DI   NCIt; C35417; Intrahepatic cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   71Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
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RX   CelloPub=CLPUB00275;
RA   Zach S., Birgin E., Ruckert F.;
RT   "Primary cholangiocellular carcinoma cell lines.";
RL   J. Stem Cell Res. Transplant. 2:1013-1013(2015).
//
RX   CelloPub=CLPUB00469;
RA   Homma S.;
RT   "Studies on the establishment and some biological characteristics of
RT   cultured human liver cancer cell lines. Their growth, functional and
RT   morphological characteristics and temperature sensitivities.";
RL   Jikeikai Med. J. 32:289-315(1985).
//
RX   PubMed=2889643; DOI=10.1007/BF02773816;
RA   Homma S., Nagamori S., Fujise K., Yamazaki K., Hasumura S., Sujino H.,
RA   Matsuura T., Shimizu K., Kameda H., Takaki K.;
RT   "Human bile duct carcinoma cell line producing abundant mucin in
RT   vitro.";
RL   Gastroenterol. Jpn. 22:474-479(1987).
//
RX   PubMed=21451941; DOI=10.1007/s00534-011-0376-7;
RA   Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y.,
RA   Tsuchiya T., Gotoh M.;
RT   "Gene expression analysis for predicting gemcitabine resistance in
RT   human cholangiocarcinoma.";
RL   J. Hepatobiliary Pancreat. Sci. 18:700-711(2011).
//
RX   PubMed=26956050; DOI=10.18632/oncotarget.7914; PMCID=PMC4991440;
RA   Ding X.-W., Chaiteerakij R., Moser C.D., Shaleh H.M., Boakye J.,
RA   Chen G., Ndzengue A., Li Y., Zhou Y.-L., Huang S.-B., Sinicrope F.A.,
RA   Zou X.-P., Thomas M.B., Smith C.D., Roberts L.R.;
RT   "Antitumor effect of the novel sphingosine kinase 2 inhibitor
RT   ABC294640 is enhanced by inhibition of autophagy and by sorafenib in
RT   human cholangiocarcinoma cells.";
RL   Oncotarget 7:20080-20092(2016).
//
RX   PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451;
RA   Scherer D., Davila-Lopez M., Goeppert B., Abrahamsson S.,
RA   Gonzalez Silos R., Nova I., Marcelain K., Roa J.C., Ibberson D.,
RA   Umu S.U., Rounge T.B., Roessler S., Lorenzo-Bermejo J.;
RT   "RNA sequencing of hepatobiliary cancer cell lines: data and
RT   applications to mutational and transcriptomic profiling.";
RL   Cancers (Basel) 12:2510.1-2510.14(2020).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//
RX   PubMed=39026794; DOI=10.1101/2024.07.04.601970; PMCID=PMC11257448;
RA   Vijay V., Karisani N., Shi L., Hung Y.-H., Vu P., Kattel P., Kenney L.,
RA   Merritt J., Adil R., Wu Q.-B., Zhen Y.-L., Morris R., Kreuzer J.,
RA   Kathiresan M., Herrera Lopez X.I., Ellis H., Gritti I.G., Lecorgne L.,
RA   Farag I., Popa A., Shen W., Kato H., Xu Q., Balasooriya E.R., Wu M.-J.,
RA   Chaturantabut S., Kelley R.K., Cleary J.M., Lawrence M.S., Root D.E.,
RA   Benes C.H., Deshpande V., Juric D., Sellers W.R., Ferrone C.R., Haas W.,
RA   Vazquez F., Getz G., Bardeesy N.M.;
RT   "Generation of a biliary tract cancer cell line atlas reveals
RT   molecular subtypes and therapeutic targets.";
RL   bioRxiv 2024:07.04.601970-07.04.601970(2024).
//