ID   OVMANA
AC   CVCL_3111
DR   BTO; BTO_0003500
DR   EFO; EFO_0006726
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 493
DR   BioSample; SAMN03472488
DR   BioSample; SAMN10988029
DR   cancercelllines; CVCL_3111
DR   Cell_Model_Passport; SIDM01378
DR   CGH-DB; 337-2
DR   Cosmic; 1223317
DR   Cosmic; 1305330
DR   Cosmic; 1328066
DR   Cosmic; 1434894
DR   Cosmic; 1708384
DR   Cosmic; 2074247
DR   Cosmic; 2482707
DR   DepMap; ACH-000646
DR   EGA; EGAS00001000610
DR   GEO; GSM416679
DR   GEO; GSM459731
DR   GEO; GSM659397
DR   GEO; GSM887488
DR   GEO; GSM888570
DR   GEO; GSM1176281
DR   IARC_TP53; 30141
DR   JCRB; JCRB1045
DR   JCRB; NIHS0298
DR   JCRB; NIHS0340
DR   LiGeA; CCLE_247
DR   PharmacoDB; OVMANA_1225_2019
DR   PRIDE; PXD003105
DR   Progenetix; CVCL_3111
DR   Wikidata; Q54937031
RX   PubMed=9328139;
RX   PubMed=11121861;
RX   PubMed=15677628;
RX   PubMed=17671176;
RX   PubMed=20081105;
RX   PubMed=22460905;
RX   PubMed=22705003;
RX   PubMed=22710073;
RX   PubMed=23839242;
RX   PubMed=24023729;
RX   PubMed=25485619;
RX   PubMed=25984343;
RX   PubMed=26589293;
RX   PubMed=26972028;
RX   PubMed=27141528;
RX   PubMed=28196595;
RX   PubMed=30485824;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Japanese.
CC   Doubling time: 67 hours (PubMed=9328139; PubMed=11121861); 70 hours (PubMed=25984343); 50-60 hours (Note=Lot 02042008), ~55-60 hours (Note=Lot 09042012), ~38 hours (Note=Lot 05022017) (JCRB=JCRB1045).
CC   HLA typing: A*24:02,24:02; B*07:02,54:01; C*01:02,07:02; DQA1*03:02,03:02; DQB1*04:01,04:01; DRB1*15:01,15:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Val (c.1634A>T); ClinVar=VCV000375897; Zygosity=Unspecified (PubMed=22705003).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; PTM; GPI-anchored proteins.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=79.88%; East Asian, South=19.76%; South Asian=0%; European, North=0.36%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; NIHS0298; true.
CC   Discontinued: JCRB; NIHS0340; true.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): JCRB=JCRB1045; PubMed=22710073; PubMed=30485824
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 8,9
ST   D16S539: 10
ST   D18S51: 16
ST   D19S433: 14
ST   D21S11: 28,31
ST   D2S1338: 24
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 10,11
ST   D8S1179: 10,15
ST   FGA: 21,24
ST   TH01: 7,9
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C40078; Ovarian clear cell adenocarcinoma
DI   ORDO; Orphanet_398971; Clear cell adenocarcinoma of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011;
RA   Rahman, Munmun
RA   Nakayama, Kentaro
RA   Rahman, Mohammed Tanjimur
RA   Nakayama, Naomi
RA   Ishikawa, Masako
RA   Katagiri, Atsuko
RA   Iida, Kouji
RA   Nakayama, Satoru
RA   Otsuki, Yoshiro
RA   Shih, Ie-Ming
RA   Miyazaki, Kohji
RT   "Clinicopathologic and biological analysis of PIK3CA mutation in
RT   ovarian clear cell carcinoma.";
RL   Hum. Pathol. 43:2197-2206(2012).
//
RX   PubMed=9328139; DOI=10.1038/bjc.1997.471; PMCID=PMC2228076;
RA   Yanagibashi, Takendo
RA   Gorai, Itsuo
RA   Nakazawa, Tsuneo
RA   Miyagi, Etsuko
RA   Hirahara, Fumiki
RA   Kitamura, Hitoshi
RA   Minaguchi, Hiroshi
RT   "Complexity of expression of the intermediate filaments of six new
RT   human ovarian carcinoma cell lines: new expression of cytokeratin
RT   20.";
RL   Br. J. Cancer 76:829-835(1997).
//
RX   PubMed=20081105; DOI=10.1210/me.2009-0295; PMCID=PMC2817607;
RA   Nagaraja, Ankur K.
RA   Creighton, Chad Jeremy
RA   Yu, Zhi-Feng
RA   Zhu, Hui-Feng
RA   Gunaratne, Preethi H.
RA   Reid, Jeffrey G.
RA   Olokpa, Emuejevoke
RA   Itamochi, Hiroaki
RA   Ueno, Naoto Tada
RA   Hawkins, Shannon M.
RA   Anderson, Matthew Linley
RA   Matzuk, Martin Matthew
RT   "A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.";
RL   Mol. Endocrinol. 24:447-463(2010).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866;
RA   Domcke, Silvia
RA   Sinha, Rileen
RA   Levine, Douglas A.
RA   Sander, Chris
RA   Schultz, Nikolaus
RT   "Evaluating cell lines as tumour models by comparison of genomic
RT   profiles.";
RL   Nat. Commun. 4:2126.1-2126.10(2013).
//
RX   PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008;
RA   Masuishi, Yusuke
RA   Kimura, Yayoi
RA   Arakawa, Noriaki
RA   Hirano, Hisashi
RT   "Identification of glycosylphosphatidylinositol-anchored proteins and
RT   omega-sites using TiO2-based affinity purification followed by
RT   hydrogen fluoride treatment.";
RL   J. Proteomics 139:77-83(2016).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945;
RA   Papp, Eniko
RA   Hallberg, Dorothy
RA   Konecny, Gottfried E.
RA   Bruhm, Daniel C.
RA   Adleff, Vilmos
RA   Noe, Michael
RA   Kagiampakis, Ioannis
RA   Palsgrove, Doreen
RA   Conklin, Dylan
RA   Kinose, Yasuto
RA   White, James R.
RA   Press, Michael Frederick
RA   Drapkin, Ronny I.
RA   Easwaran, Hariharan
RA   Baylin, Stephen Bruce
RA   Slamon, Dennis Joseph
RA   Velculescu, Victor E.
RA   Scharpf, Robert B.
RT   "Integrated genomic, epigenomic, and expression analyses of ovarian
RT   cancer cell lines.";
RL   Cell Rep. 25:2617-2633(2018).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Pharoah, Paul D.P.
RA   Staines, Joanne M.
RA   Oliveira, Carla
RA   Edwards, Paul A.W.
RA   Caldas, Carlos
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567;
RA   Kikuchi, Ryoko
RA   Tsuda, Hitoshi
RA   Kanai, Yae
RA   Kasamatsu, Takahiro
RA   Sengoku, Kazuo
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RA   Imoto, Issei
RT   "Promoter hypermethylation contributes to frequent inactivation of a
RT   putative conditional tumor suppressor gene connective tissue growth
RT   factor in ovarian cancer.";
RL   Cancer Res. 67:7095-7105(2007).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27141528; DOI=10.1016/j.dib.2016.04.001; PMCID=PMC4838930;
RA   Masuishi, Yusuke
RA   Kimura, Yayoi
RA   Arakawa, Noriaki
RA   Hirano, Hisashi
RT   "Data for identification of GPI-anchored peptides and omega-sites in
RT   cancer cell lines.";
RL   Data Brief 7:1302-1305(2016).
//
RX   PubMed=11121861; DOI=10.1016/S0304-3835(00)00605-4;
RA   Ohta, Ichiro
RA   Gorai, Itsuo
RA   Miyamoto, Yasunori
RA   Yang, Jun
RA   Zheng, Jian-Hua
RA   Kawata, Naomi
RA   Hirahara, Fumiki
RA   Shirotake, Shoichi
RT   "Cyclophosphamide and 5-fluorouracil act synergistically in ovarian
RT   clear cell adenocarcinoma cells.";
RL   Cancer Lett. 162:39-48(2001).
//
RX   PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837;
RA   Anglesio, Michael S.
RA   Wiegand, Kimberly C.
RA   Melnyk, Nataliya
RA   Chow, Christine
RA   Salamanca, Clara M.
RA   Prentice, Leah M.
RA   Senz, Janine
RA   Yang, Winnie
RA   Spillman, Monique Ann
RA   Cochrane, Dawn R.
RA   Shumansky, Karey
RA   Shah, Sohrab P.
RA   Kalloger, Steve E.
RA   Huntsman, David G.
RT   "Type-specific cell line models for type-specific ovarian cancer
RT   research.";
RL   PLoS ONE 8:e72162.1-e72162.13(2013).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//