ID OVKATE AC CVCL_3110 DR BTO; BTO_0003503 DR CLO; CLO_0037098 DR EFO; EFO_0006725 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03472859 DR BioSample; SAMN10988314 DR cancercelllines; CVCL_3110 DR Cell_Model_Passport; SIDM00466 DR CGH-DB; 338-2 DR Cosmic; 1995607 DR Cosmic-CLP; 1240199 DR DepMap; ACH-000443 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 1240199 DR GEO; GSM659396 DR GEO; GSM887487 DR GEO; GSM888569 DR GEO; GSM1670323 DR IARC_TP53; 28276 DR JCRB; JCRB1044 DR JCRB; NIHS0297 DR JCRB; NIHS0339 DR LINCS_LDP; LCL-1525 DR PharmacoDB; OVKATE_1224_2019 DR PRIDE; PXD003668 DR PRIDE; PXD030304 DR Progenetix; CVCL_3110 DR Wikidata; Q54937030 RX DOI=10.1016/j.jveb.2019.04.010; RX PubMed=9328139; RX PubMed=11121861; RX PubMed=15677628; RX PubMed=17671176; RX PubMed=22460905; RX PubMed=23839242; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=27561551; RX PubMed=30485824; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: 96 hours (PubMed=9328139; PubMed=11121861). CC HLA typing: A*26:01,26:01; B*07:02,07:02; C*07:02,07:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:3942; MTOR; Simple; p.Thr1834_Thr1837delThrAlaAlaThr (c.5490_5501delGTGGTGGCGGCA); Zygosity=Heterozygous (Cosmic-CLP=1240199; DepMap=ACH-000443). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Homozygous (Cosmic-CLP=1240199; DepMap=ACH-000443). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.37%; Native American=0%; East Asian, North=79.04%; East Asian, South=17.87%; South Asian=0%; European, North=0%; European, South=0.72% (PubMed=30894373). CC Anecdotal: Dogs were trained to recognize the odor of this cell line so as to later detect ovarian cancer from blood samples (DOI=10.1016/j.jveb.2019.04.010). CC Discontinued: JCRB; NIHS0297; true. CC Discontinued: JCRB; NIHS0339; true. CC Derived from site: In situ; Ovary; UBERON=UBERON_0000992. ST Source(s): Cosmic-CLP=1240199; JCRB=JCRB1044; PubMed=25877200; PubMed=30485824 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 12 ST D16S539: 9 ST D18S51: 12 ST D19S433: 14,15.2 ST D21S11: 30,33.2 ST D2S1338: 18,23 ST D3S1358: 18 ST D5S818: 9,13 ST D7S820: 11,12 ST D8S1179: 11 ST FGA: 19 ST Penta D: 9,13 ST Penta E: 5,11 ST TH01: 9 ST TPOX: 8,11 ST vWA: 18 DI NCIt; C105555; High grade ovarian serous adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 40Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 36 // RX PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866; RA Domcke, Silvia RA Sinha, Rileen RA Levine, Douglas A. RA Sander, Chris RA Schultz, Nikolaus RT "Evaluating cell lines as tumour models by comparison of genomic RT profiles."; RL Nat. Commun. 4:2126.1-2126.10(2013). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461; RA Coscia, Fabian RA Watters, Karen M. RA Curtis, Marion RA Eckert, Mark A. RA Chiang, Chun-Yi RA Tyanova, Stefka RA Montag, Anthony RA Lastra, Ricardo R. RA Lengyel, Ernst Robert RA Mann, Matthias RT "Integrative proteomic profiling of ovarian cancer cell lines reveals RT precursor cell associated proteins and functional status."; RL Nat. Commun. 7:12645.1-12645.14(2016). // RX PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945; RA Papp, Eniko RA Hallberg, Dorothy RA Konecny, Gottfried E. RA Bruhm, Daniel C. RA Adleff, Vilmos RA Noe, Michael RA Kagiampakis, Ioannis RA Palsgrove, Doreen RA Conklin, Dylan RA Kinose, Yasuto RA White, James R. RA Press, Michael Frederick RA Drapkin, Ronny I. RA Easwaran, Hariharan RA Baylin, Stephen Bruce RA Slamon, Dennis Joseph RA Velculescu, Victor E. RA Scharpf, Robert B. RT "Integrated genomic, epigenomic, and expression analyses of ovarian RT cancer cell lines."; RL Cell Rep. 25:2617-2633(2018). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567; RA Kikuchi, Ryoko RA Tsuda, Hitoshi RA Kanai, Yae RA Kasamatsu, Takahiro RA Sengoku, Kazuo RA Hirohashi, Setsuo RA Inazawa, Johji RA Imoto, Issei RT "Promoter hypermethylation contributes to frequent inactivation of a RT putative conditional tumor suppressor gene connective tissue growth RT factor in ovarian cancer."; RL Cancer Res. 67:7095-7105(2007). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=9328139; DOI=10.1038/bjc.1997.471; PMCID=PMC2228076; RA Yanagibashi, Takendo RA Gorai, Itsuo RA Nakazawa, Tsuneo RA Miyagi, Etsuko RA Hirahara, Fumiki RA Kitamura, Hitoshi RA Minaguchi, Hiroshi RT "Complexity of expression of the intermediate filaments of six new RT human ovarian carcinoma cell lines: new expression of cytokeratin RT 20."; RL Br. J. Cancer 76:829-835(1997). // RX PubMed=11121861; DOI=10.1016/S0304-3835(00)00605-4; RA Ohta, Ichiro RA Gorai, Itsuo RA Miyamoto, Yasunori RA Yang, Jun RA Zheng, Jian-Hua RA Kawata, Naomi RA Hirahara, Fumiki RA Shirotake, Shoichi RT "Cyclophosphamide and 5-fluorouracil act synergistically in ovarian RT clear cell adenocarcinoma cells."; RL Cancer Lett. 162:39-48(2001). // RX PubMed=15677628; DOI=10.1093/carcin/bgi032; RA Gorringe, Kylie Louise RA Chin, Suet-Feung RA Pharoah, Paul D.P. RA Staines, Joanne M. RA Oliveira, Carla RA Edwards, Paul A.W. RA Caldas, Carlos RT "Evidence that both genetic instability and selection contribute to RT the accumulation of chromosome alterations in cancer."; RL Carcinogenesis 26:923-930(2005). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX DOI=10.1016/j.jveb.2019.04.010; RA Murarka, Monisha RA Vesley-Gross, Zoe I. RA Essler, Jennifer Lynn RA Smith, Paige G. RA Hooda, Jagmohan RA Drapkin, Ronny I. RA Otto, Cynthia M. RT "Testing ovarian cancer cell lines to train dogs to detect ovarian RT cancer from blood plasma: a pilot study."; RL J. Vet. Behav. 32:42-48(2019). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). //