ID   OSC-20
AC   CVCL_3087
SY   OSC20
DR   CLO; CLO_0009950
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 979
DR   cancercelllines; CVCL_3087
DR   Cell_Model_Passport; SIDM00565
DR   Cosmic; 1120702
DR   Cosmic; 1995604
DR   Cosmic-CLP; 1240196
DR   DepMap; ACH-001626
DR   EGA; EGAS00001000978
DR   GDSC; 1240196
DR   GEO; GSM827220
DR   GEO; GSM1670309
DR   JCRB; FDSC0051
DR   JCRB; JCRB0197
DR   LINCS_LDP; LCL-1220
DR   PharmacoDB; OSC20_1206_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_3087
DR   Wikidata; Q54936583
RX   DOI=10.15114/tr.25.93;
RX   DOI=10.15114/tr.35.25;
RX   PubMed=9119748;
RX   PubMed=12716470;
RX   PubMed=19123955;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Doubling time: 27.4 hours (Note=At 35th passage) (DOI=10.15114/tr.25.93); 65 hours (Note=Lot 02032003), ~49 hours (Note=Lot 11152011), ~35 hours (Note=Lot 07182019) (JCRB=JCRB0197).
CC   HLA typing: A*02,11; B*46,55; C*w01,w09 (PubMed=9119748).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Pro81Leu (c.242C>T); ClinVar=VCV000833629; Zygosity=Homozygous (Cosmic-CLP=1240196; DepMap=ACH-001626).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1048Arg (c.3143A>G); ClinVar=VCV000450316; Zygosity=Heterozygous (Cosmic-CLP=1240196; DepMap=ACH-001626).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (Cosmic-CLP=1240196; DepMap=ACH-001626).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=3.14%; Native American=0.23%; East Asian, North=75.72%; East Asian, South=16.66%; South Asian=0%; European, North=0%; European, South=4.24% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0051; true.
CC   Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
ST   Source(s): Cosmic-CLP=1240196; DepMap=ACH-001626
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 8
ST   D16S539: 9,13
ST   D18S51: 13
ST   D21S11: 29,32.2
ST   D3S1358: 16
ST   D5S818: 13 (Cosmic-CLP=1240196)
ST   D5S818: 13,14 (DepMap=ACH-001626)
ST   D7S820: 10
ST   D8S1179: 12,14
ST   FGA: 22
ST   Penta D: 9,12
ST   Penta E: 14,16
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_WW78 ! TcOSC-20
SX   Female
AG   59Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   DOI=10.15114/tr.25.93;
RA   Yokoi, Toshikazu
RA   Hirata, Shoji
RA   Nishimura, Fumikatu
RA   Miyakawa, Akira
RA   Odajima, Tetsuyo
RA   Kohama, Gen-iku
RA   Mochizuki, Yohichi
RT   "Some properties of a newly established human cell line from a oral
RT   squamous carcinoma.";
RL   Tumor Res. 25:93-103(1990).
//
RX   DOI=10.15114/tr.35.25;
RA   Yonekura, Noriyuki
RA   Yokosawa, Noriko
RA   Hariya, Yasushi
RA   Dehari, Hironari
RA   Kohama, Gen-iku
RA   Fujii, Nobuhiro
RT   "Interferon-alpha and interferon-gamma augment apoptosis in oral
RT   carcinoma cells treated with Shiga toxin 2 (Stx2).";
RL   Tumor Res. 35:25-33(2000).
//
RX   PubMed=19123955; DOI=10.1186/1479-5876-7-1; PMCID=PMC2627828;
RA   Kobayashi, Jun-ichi
RA   Torigoe, Toshihiko
RA   Hirohashi, Yoshihiko
RA   Idenoue, Satomi
RA   Miyazaki, Akihiro
RA   Yamaguchi, Akira
RA   Hiratsuka, Hiroyoshi
RA   Sato, Noriyuki
RT   "Comparative study on the immunogenicity between an HLA-A24-restricted
RT   cytotoxic T-cell epitope derived from survivin and that from its
RT   splice variant survivin-2B in oral cancer patients.";
RL   J. Transl. Med. 7:1.1-1.11(2009).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=9119748; DOI=10.1111/j.1349-7006.1997.tb00365.x; PMCID=PMC5921363;
RA   Miyazaki, Akihiro
RA   Sato, Noriyuki
RA   Takahashi, Shuji
RA   Sasaki, Aya
RA   Kohama, Gen-iku
RA   Yamaguchi, Akira
RA   Yagihashi, Atsuhito
RA   Kikuchi, Kokichi
RT   "Cytotoxicity of histocompatibility leukocyte antigen-DR8-restricted
RT   CD4 killer T cells against human autologous squamous cell
RT   carcinoma.";
RL   Jpn. J. Cancer Res. 88:191-197(1997).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=12716470; DOI=10.1111/j.1349-7006.2002.tb01338.x; PMCID=PMC5927106;
RA   Kondo, Hiroaki
RA   Sahara, Hiroeki
RA   Miyazaki, Akihiro
RA   Nabeta, Yuki
RA   Hirohashi, Yoshihiko
RA   Kanaseki, Takayuki
RA   Yamaguchi, Akira
RA   Yamada, Naoyuki
RA   Hirayama, Kazuo
RA   Suzuki, Manabu
RA   Hamuro, Junji
RA   Torigoe, Toshihiko
RA   Takahashi, Nobuaki
RA   Kohama, Gen-iku
RA   Ikeda, Hideyuki
RA   Sato, Noriyuki
RT   "Natural antigenic peptides from squamous cell carcinoma recognized by
RT   autologous HLA-DR8-restricted CD4+ T cells.";
RL   Jpn. J. Cancer Res. 93:917-924(2002).
//