ID NUGC-4 AC CVCL_3082 AS CVCL_8372 SY NUGC4; NU-GC-4; Nagoya University-Gastric Cancer-4 DR BTO; BTO_0005917 DR CLO; CLO_0050789 DR EFO; EFO_0006703 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN01821711 DR BioSample; SAMN03473124 DR BioSample; SAMN10987867 DR cancercelllines; CVCL_3082 DR Cell_Model_Passport; SIDM00570 DR CGH-DB; 135-1 DR ChEMBL-Cells; CHEMBL3307267 DR ChEMBL-Targets; CHEMBL613519 DR Cosmic; 1187289 DR Cosmic; 1329186 DR Cosmic; 1460702 DR Cosmic; 1518257 DR Cosmic; 1890473 DR Cosmic; 2009530 DR Cosmic; 2484971 DR Cosmic; 2807639 DR Cosmic-CLP; 1298357 DR DepMap; ACH-000674 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10483-107A6 DR GDSC; 1298357 DR GEO; GSM552368 DR GEO; GSM827575 DR GEO; GSM844667 DR GEO; GSM887463 DR GEO; GSM888543 DR GEO; GSM1374777 DR GEO; GSM1670288 DR IARC_TP53; 25015 DR JCRB; JCRB0834 DR LiGeA; CCLE_273 DR LINCS_LDP; LCL-2001 DR PharmacoDB; NUGC4_1174_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_3082 DR PubChem_Cell_line; CVCL_3082 DR RCB; RCB1939 DR TKG; TKG 0449 DR Wikidata; Q54931165 RX PubMed=1370612; RX PubMed=1778766; RX PubMed=2474525; RX PubMed=3172586; RX PubMed=9290701; RX PubMed=11314020; RX PubMed=15723654; RX PubMed=15900046; RX PubMed=19132987; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=24587255; RX PubMed=24807215; RX PubMed=25343454; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=29435981; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: 29.9 hours (PubMed=3172586); 27 hours (PubMed=29435981). CC HLA typing: A*02:01,24:02; B*46:01,51:02; C*01:02,15:02; DRB1*11:67,12:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=1370612; PubMed=15900046). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.72%; East Asian, North=65.95%; East Asian, South=32.05%; South Asian=0%; European, North=0%; European, South=1.27% (PubMed=30894373). CC Misspelling: MUGC-4; Cosmic=1187289; PubMed=19132987. CC Derived from site: Metastatic; Paragastric lymph node; UBERON=UBERON_8480059. ST Source(s): Cosmic-CLP=1298357; JCRB=JCRB0834; PubMed=25877200; RCB=RCB1939 ST Amelogenin: X ST CSF1PO: 10,11 ST D13S317: 11,13 ST D16S539: 9 ST D18S51: 16,19 ST D21S11: 30.3,31 ST D3S1358: 15,16 ST D5S818: 11,12 ST D7S820: 11 ST D8S1179: 12 ST FGA: 23,26 ST Penta D: 9,12 ST Penta E: 13,15 ST TH01: 7,9 ST TPOX: 8,9 ST vWA: 14,18 DI NCIt; C5250; Gastric signet ring cell adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 35Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 44 CH CVCL_A8GI ! NUC12N2 // RX PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760; RA Liu, Jin-Feng RA McCleland, Mark L. RA Stawiski, Eric W. RA Gnad, Florian RA Mayba, Oleg RA Haverty, Peter M. RA Durinck, Steffen RA Chen, Ying-Jiun RA Klijn, Christiaan RA Jhunjhunwala, Suchit RA Lawrence, Michael RA Liu, Han-Bin RA Wan, Yi-Nan RA Chopra, Vivek S. RA Yaylaoglu, Murat Burat RA Yuan, Wen-Lin RA Ha, Connie RA Gilbert, Houston N. RA Reeder, Jens RA Pau, Gregoire RA Stinson, Jeremy RA Stern, Howard M. RA Manning, Gerard RA Wu, Thomas D. RA Neve, Richard M. RA de Sauvage, Frederic J. RA Modrusan, Zora RA Seshagiri, Somasekar RA Firestein, Ron RA Zhang, Ze-Min RT "Integrated exome and transcriptome sequencing reveals ZAK isoform RT usage in gastric cancer."; RL Nat. Commun. 5:3830.1-3830.8(2014). // RX PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0; RA Matozaki, Takashi RA Sakamoto, Choitsu RA Matsuda, Kohei RA Suzuki, Toshiya RA Konda, Yoshitaka RA Nakano, Osamu RA Wada, Ken RA Uchida, Tohru RA Nishisaki, Hogara RA Nagao, Munehiko RA Kasuga, Masato RT "Missense mutations and a deletion of the p53 gene in human gastric RT cancer."; RL Biochem. Biophys. Res. Commun. 182:215-223(1992). // RX PubMed=24587255; DOI=10.1371/journal.pone.0090155; PMCID=PMC3937424; RA Endo, Fumitaka RA Nishizuka, Satoshi S. RA Kume, Kohei RA Ishida, Kazushige RA Katagiri, Hirokatsu RA Ishida, Kaoru RA Sato, Kei RA Iwaya, Takeshi RA Koeda, Keisuke RA Wakabayashi, Go RT "A compensatory role of NF-kappaB to p53 in response to 5-FU-based RT chemotherapy for gastric cancer cell lines."; RL PLoS ONE 9:e90155.1-e90155.8(2014). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia, Li-Qun RA Osada, Motonobu RA Ishioka, Chikashi RA Gamo, Makio RA Ikawa, Shuntaro RA Suzuki, Takao RA Shimodaira, Hideki RA Niitani, Tomohito RA Kudo, Toshio RA Akiyama, Mitoshi RA Kimura, Narimiti RA Matsuo, Mitsuyoshi RA Mizusawa, Hiroshi RA Tanaka, Noriho RA Koyama, Hideki RA Namba, Masayoshi RA Kanamaru, Ryunosuke RA Kuroki, Toshio RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020; RA Takada, Hisashi RA Imoto, Issei RA Tsuda, Hitoshi RA Sonoda, Itaru RA Ichikura, Takashi RA Mochizuki, Hidetaka RA Okanoue, Takeshi RA Inazawa, Johji RT "Screening of DNA copy-number aberrations in gastric cancer cell lines RT by array-based comparative genomic hybridization."; RL Cancer Sci. 96:100-110(2005). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima, Tetsuo RA Oh-hara, Tomoko RA Sato, Shigeo RA Mochizuki, Mikiko RA Sugimoto, Yoshikazu RA Yamazaki, Kanami RA Hamada, Jun-ichi RA Tada, Mitsuhiro RA Moriuchi, Tetsuya RA Ishikawa, Yuichi RA Kato, Yo RA Tomoda, Hiroshi RA Yamori, Takao RA Tsuruo, Takashi RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=3172586; DOI=10.1007/BF02471470; RA Akiyama, Seiji RA Amo, Hiroyuki RA Watanabe, Tadashi RA Matsuyama, Mutsushi RA Sakamoto, Junichi RA Imaizumi, Munehisa RA Ichihashi, Hidehito RA Kondo, Tatsuhei RA Takagi, Hiroshi RT "Characteristics of three human gastric cancer cell lines, NU-GC-2, RT NU-GC-3 and NU-GC-4."; RL Jpn. J. Surg. 18:438-446(1988). // RX PubMed=19132987; DOI=10.1111/j.1600-0463.2008.01042.x; RA Li, Yu-Qin RA Tanaka, Yasuo RA Tada, Motohisa RA Hua, Rui RA Seto, Motoko RA Asaoka, Yoshinari RA Ohta, Miki RA Kanai, Fumihiko RA Yoshida, Haruhiko RA Kawabe, Takao RA Sano, Takaaki RA Motojima, Teiji RA Yokosuka, Osamu RA Omata, Masao RT "Absence of the AKT1 pleckstrin homology domain mutation in Japanese RT gastrointestinal and liver cancer patients."; RL APMIS 116:931-933(2008). // RX PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361; RA Takeshima, Eisuke RA Hamaguchi, Michinari RA Watanabe, Tadashi RA Akiyama, Seiji RA Kataoka, Masato RA Ohnishi, Yukano RA Xiao, Heng-Yi RA Nagai, Yoshiyuki RA Takagi, Hiroshi RT "Aberrant elevation of tyrosine-specific phosphorylation in human RT gastric cancer cells."; RL Jpn. J. Cancer Res. 82:1428-1435(1991). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=29435981; DOI=10.1002/ijc.31304; RA Kim, Hyun Jeong RA Kang, Sun Kyoung RA Kwon, Woo Sun RA Kim, Tae Soo RA Jeong, Inhye RA Jeung, Hei-Cheul RA Kragh, Michael RA Horak, Ivan D. RA Chung, Hyun Cheol RA Rha, Sun Young RT "Forty-nine gastric cancer cell lines with integrative genomic RT profiling for development of c-MET inhibitor."; RL Int. J. Cancer 143:151-159(2018). // RX PubMed=11314020; DOI=10.1038/sj.onc.1204160; RA Kataoka, Hiromi RA Miura, Yutaka RA Joh, Takashi RA Seno, Kyoji RA Tada, Toyohiro RA Tamaoki, Taiki RA Nakabayashi, Hidekazu RA Kawaguchi, Makoto RA Asai, Kiyofumi RA Kato, Taiji RA Itoh, Makoto RT "Alpha-fetoprotein producing gastric cancer lacks transcription factor RT ATBF1."; RL Oncogene 20:869-873(2001). // RX PubMed=2474525; DOI=10.1111/j.1349-7006.1989.tb01674.x; PMCID=PMC5917803; RA Yoshikawa, Kazuhiro RA Furukawa, Koichi RA Ueda, Ryuzo RA Iwasa, Susumu RA Lloyd, Kenneth Oliver RA Notake, Kunihiro RA Takahashi, Toshitada RT "A human monoclonal antibody recognizing a surface antigen on stomach RT cancer cells."; RL Jpn. J. Cancer Res. 80:546-553(1989). // RX PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810; RA Choong, Meng-Ling RA Tan, Shan-Ho RA Tan, Tuan-Zea RA Manesh, Sravanthy RA Ngo, Anna RA Yong, Jacklyn W.-Y. RA Yang, Henry He RA Lee, May Ann RT "Molecular integrative clustering of Asian gastric cell lines revealed RT two distinct chemosensitivity clusters."; RL PLoS ONE 9:e111146.1-e111146.9(2014). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //