ID   184A1
AC   CVCL_3040
AS   CVCL_8222
SY   184 A1; H184A1
DR   CLO; CLO_0001137
DR   EFO; EFO_0022348
DR   ATCC; CRL-8798
DR   BioSample; SAMN03471210
DR   cancercelllines; CVCL_3040
DR   DepMap; ACH-002319
DR   GEO; GSM350522
DR   GEO; GSM843436
DR   GEO; GSM845393
DR   GEO; GSM1172844
DR   GEO; GSM1172932
DR   IZSLER; BS CL 178
DR   LINCS_HMS; 51088
DR   LINCS_LDP; LCL-2080
DR   PharmacoDB; 184A1_4_2019
DR   Progenetix; CVCL_3040
DR   Wikidata; Q54582476
RX   DOI=10.1007/978-1-4612-0411-4_26;
RX   Patent=US4808532;
RX   PubMed=2702624;
RX   PubMed=3857588;
RX   PubMed=8504475;
RX   PubMed=9398663;
RX   PubMed=9671407;
RX   PubMed=12661003;
RX   PubMed=19582160;
RX   PubMed=24176112;
RX   PubMed=25960936;
RX   PubMed=28196595;
RX   PubMed=28889351;
WW   Info; -; -; https://hmec.lbl.gov/mreview.htm
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Group: Patented cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8798.
CC   Doubling time: 58.07 hours (JWGray panel).
CC   HLA typing: A*02:01,02:01; B*18:01,18:01; C*07:01,07:01 (PubMed=25960936).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003).
CC   Transformant: ChEBI; CHEBI_29865; Benzo[a]pyrene.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
ST   Source(s): ATCC=CRL-8798; IZSLER=BS CL 178; PubMed=28889351
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 12,14
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 17,23
ST   D3S1358: 15
ST   D5S818: 11,13
ST   D7S820: 9,11
ST   D8S1179: 11,13
ST   FGA: 19,22
ST   Penta D: 12,13
ST   Penta E: 7,14
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 18,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_K049 ! 184
SX   Female
AG   21Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
CH   CVCL_9665 ! 184A1N4
//
RX   Patent=US4808532;
RA   Stampfer, Martha Ruskin
RT   "Continuous human cell lines and method of making same.";
RL   Patent number US4808532, 28-Feb-1989.
//
RX   PubMed=3857588; DOI=10.1073/pnas.82.8.2394; PMCID=PMC397564;
RA   Stampfer, Martha Ruskin
RA   Bartley, Jack C.
RT   "Induction of transformation and continuous cell lines from normal
RT   human mammary epithelial cells after exposure to benzo[a]pyrene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:2394-2398(1985).
//
RX   PubMed=28889351; DOI=10.1007/s10549-017-4496-x;
RA   Saunus, Jodi M.
RA   Smart, Chanel E.
RA   Kutasovic, Jamie R.
RA   Johnston, Rebecca L.
RA   Kalita-de Croft, Priyakshi
RA   Miranda, Mariska
RA   Rozali, Esdy N.
RA   Vargas, Ana Cristina
RA   Reid, Lynne E.
RA   Lorsy, Eva
RA   Cocciardi, Sibylle
RA   Seidens, Tatjana
RA   McCart Reed, Amy Ellen
RA   Dalley, Andrew J.
RA   Wockner, Leesa F.
RA   Johnson, Julie
RA   Sarkar, Debina
RA   Askarian-Amiri, Marjan E.
RA   Simpson, Peter T.
RA   Khanna, Kum Kum
RA   Chenevix-Trench, Georgia
RA   Al-Ejeh, Fares
RA   Lakhani, Sunil R.
RT   "Multidimensional phenotyping of breast cancer cell lines to guide
RT   preclinical research.";
RL   Breast Cancer Res. Treat. 167:289-301(2018).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=9671407; DOI=10.1038/sj.onc.1201814;
RA   Sweeney, Kimberley J.
RA   Swarbrick, Alexander
RA   Sutherland, Robert Lyndsay
RA   Musgrove, Elizabeth A.
RT   "Lack of relationship between CDK activity and G1 cyclin expression in
RT   breast cancer cells.";
RL   Oncogene 16:2865-2878(1998).
//
RX   PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084;
RA   Kao, Jessica
RA   Salari, Keyan
RA   Bocanegra, Melanie
RA   Choi, Yoon-La
RA   Girard, Luc
RA   Gandhi, Jeet
RA   Kwei, Kevin A.
RA   Hernandez-Boussard, Tina
RA   Wang, Pei
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Pollack, Jonathan R.
RT   "Molecular profiling of breast cancer cell lines defines relevant
RT   tumor models and provides a resource for cancer gene discovery.";
RL   PLoS ONE 4:e6146.1-e6146.16(2009).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=2702624; DOI=10.1016/0165-4608(89)90056-3;
RA   Walen, Kirsten H.
RA   Stampfer, Martha Ruskin
RT   "Chromosome analyses of human mammary epithelial cells at stages of
RT   chemical-induced transformation progression to immortality.";
RL   Cancer Genet. Cytogenet. 37:249-261(1989).
//
RX   DOI=10.1007/978-1-4612-0411-4_26;
RA   Stampfer, Martha Ruskin
RA   Yaswen, Paul
RA   Parry, Gordon
RA   Hosoda, Junko
RT   "An in vitro human mammary epithelial model system for studies of
RT   differentiation and carcinogenesis.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.259-267; Humana Press; New York; USA (1990).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz, Susanne
RA   Wassmuth, Peter
RA   Plaschke, Jens
RA   Schackert, Hans Konrad
RA   Karsten, Uwe
RA   Santibanez-Koref, Mauro F.
RA   Schlag, Peter Michael
RA   Scherneck, Siegfried
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, A. Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman, Teresa A.
RA   Modali, Ramakrishna V.
RA   Boukamp, Petra
RA   Stanek, Julie
RA   Bennett, William P.
RA   Welsh, Judith A.
RA   Metcalf, Robert A.
RA   Stampfer, Martha Ruskin
RA   Fusenig, Norbert E.
RA   Rogan, Eileen M.
RA   Harris, Curtis Craig
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//
RX   PubMed=9398663; DOI=10.1091/mbc.8.12.2391; PMCID=PMC25715;
RA   Stampfer, Martha Ruskin
RA   Bodnar, Andrea G.
RA   Garbe, James C.
RA   Wong, Michelle
RA   Pan, Alison
RA   Villeponteau, Bryant
RA   Yaswen, Paul
RT   "Gradual phenotypic conversion associated with immortalization of
RT   cultured human mammary epithelial cells.";
RL   Mol. Biol. Cell 8:2391-2405(1997).
//