ID KYM-1 AC CVCL_3007 SY Kym-1; KYM1 DR CLO; CLO_0037073 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03471640 DR BioSample; SAMN10988099 DR cancercelllines; CVCL_3007 DR Cell_Model_Passport; SIDM00552 DR Cosmic; 801759 DR Cosmic; 1995475 DR Cosmic; 2144781 DR Cosmic-CLP; 1240166 DR DepMap; ACH-000607 DR EGA; EGAS00001000978 DR FANTOM5_SSTAR; 10787-110H4 DR GDSC; 1240166 DR GEO; GSM827283 DR GEO; GSM887245 DR GEO; GSM888320 DR GEO; GSM1670015 DR IARC_TP53; 30110 DR JCRB; JCRB0627 DR LiGeA; CCLE_614 DR LINCS_LDP; LCL-1412 DR PharmacoDB; KYM1_799_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_3007 DR Wikidata; Q54900787 RX CelloPub=CLPUB00569; RX PubMed=1960402; RX PubMed=3830265; RX PubMed=9290701; RX PubMed=11921280; RX PubMed=17471488; RX PubMed=18082704; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=23665679; RX PubMed=23828214; RX PubMed=24418192; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=32758582; RX PubMed=35839778; CC Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a alveolar rhabdomyosarcoma (ARMS). It lacks the PAXA3-FOXO1 gene fusion characteristics of ARMS. Many papers classify it as an embryonal rhabdomyosarcoma (ERMS) and we accordingly describe it as such. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Japanese. CC Doubling time: ~75 hours (Note=At 30th passage) (PubMed=3830265); ~41 hours (Note=Lot 030499), ~26 hours (Note=Lot 02142012) (JCRB=JCRB0627). CC HLA typing: A*11:01,26:01; B*35:01,40:02; C*03:04,03:04; DQA1*05:02,05:02; DQB1*06:01,06:01; DRB1*04:04,13:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene deletion; HGNC; HGNC:11103; SMARCB1; Zygosity=Homozygous (PubMed=11921280). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=74.54%; East Asian, South=24.94%; South Asian=0.51%; European, North=0%; European, South=0% (PubMed=30894373). CC Derived from site: In situ; Neck; UBERON=UBERON_0000974. ST Source(s): Cosmic-CLP=1240166; JCRB=JCRB0627 ST Amelogenin: X ST CSF1PO: 12 ST D13S317: 8 ST D16S539: 9,10 ST D5S818: 11,14 ST D7S820: 11 ST TH01: 7,9 ST TPOX: 8,11 ST vWA: 17 DI NCIt; C8971; Embryonal rhabdomyosarcoma DI ORDO; Orphanet_99757; Embryonal rhabdomyosarcoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 9M CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 40 CH CVCL_5616 ! KYM-1D4 // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX CelloPub=CLPUB00569; RA Dickman, Paul S. RA Tsokos, Maria G. RA Triche, Timothy J. RT "Biology of rhabdomyosarcoma: cell culture, xenografts, and animal RT models."; RL (In book chapter) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer, Harold M. & Ruymann, Frederick Beeman & Pochedly, Carl Eugene (eds.); pp.49-88; CRC Press; Boca Raton; USA (1991). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=1960402; DOI=10.1016/0022-1759(91)90239-C; RA Meager, Anthony RT "A cytotoxicity assay for tumour necrosis factor using a human RT rhabdomyosarcoma cell line."; RL J. Immunol. Methods 144:141-143(1991). // RX PubMed=24418192; DOI=10.1111/cas.12352; PMCID=PMC4317948; RA Takita, Junko RA Chen, Yu-Yan RA Kato, Motohiro RA Ohki, Kentaro RA Sato, Yusuke RA Ohta, Shigeru RA Sugita, Kanji RA Nishimura, Riki RA Hoshino, Noriko RA Seki, Masafumi RA Sanada, Masashi RA Oka, Akira RA Hayashi, Yasuhide RA Ogawa, Seishi RT "Genome-wide approach to identify second gene targets for malignant RT rhabdoid tumors using high-density oligonucleotide microarrays."; RL Cancer Sci. 105:258-264(2014). // RX PubMed=17471488; DOI=10.1002/path.2170; RA Lae, Marick RA Ahn, Eun Hyun RA Mercado-Celis, Gabriela Elisa RA Chuai, Shannon RA Edgar, Mark RA Pawel, Bruce R. RA Olshen, Adam B. RA Barr, Frederic G. RA Ladanyi, Marc RT "Global gene expression profiling of PAX-FKHR fusion-positive alveolar RT and PAX-FKHR fusion-negative embryonal rhabdomyosarcomas."; RL J. 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RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=3830265; RA Sekiguchi, Morimasa RA Shiroko, Yasuko RA Suzuki, Toshimitsu RA Imada, Masaru RA Miyahara, Michinori RA Fujii, Genshichiro RT "Characterization of a human rhabdomyosarcoma cell strain in tissue RT culture."; RL Biomed. Pharmacother. 39:372-380(1985). // RX PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026; RA Komuro, Hiroaki RA Saihara, Ryoko RA Shinya, Miki RA Takita, Junko RA Kaneko, Setsuko RA Kaneko, Michio RA Hayashi, Yasuhide RT "Identification of side population cells (stem-like cell population) RT in pediatric solid tumor cell lines."; RL J. Pediatr. Surg. 42:2040-2045(2007). // RX PubMed=32758582; DOI=10.1016/j.gene.2020.145025; RA Batchu, Sai RA Kellish, Alec Sean RA Hakim, Abraham A. 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RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=23665679; DOI=10.1038/onc.2013.129; RA Sokolowski, Elizabeth I. RA Turina, Claire B. RA Kikuchi, Ken RA Langenau, David M. RA Keller, Charles RT "Proof-of-concept rare cancers in drug development: the case for RT rhabdomyosarcoma."; RL Oncogene 33:1877-1889(2014). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=11921280; DOI=10.1002/gcc.10052; RA Uno, Kaoru RA Takita, Junko RA Yokomori, Kinji RA Tanaka, Yukichi RA Ohta, Shigeru RA Shimada, Hiroyuki RA Gilles, Floyd Harry RA Sugita, Kanji RA Abe, Satoshi RA Sako, Masahiro RA Hashizume, Kohei RA Hayashi, Yasuhide RT "Aberrations of the hSNF5/INI1 gene are restricted to malignant RT rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric RT solid tumors."; RL Genes Chromosomes Cancer 34:33-41(2002). //