ID KP-1NL AC CVCL_3003 SY KP-1N-L; KP-1-NL; KP1-NL; KP1NL DR CLO; CLO_0037106 DR BioSample; SAMN10989577 DR cancercelllines; CVCL_3003 DR Cell_Model_Passport; SIDM01755 DR CGH-DB; 174-1 DR CGH-DB; 9369-4 DR Cosmic; 918048 DR DepMap; ACH-001108 DR GEO; GSM1588617 DR GEO; GSM1588629 DR IARC_TP53; 30108 DR JCRB; JCRB0177.1 DR JCRB; NIHS0274.1 DR LINCS_LDP; LCL-1794 DR PharmacoDB; KP1NL_782_2019 DR Wikidata; Q54900357 RX PubMed=2172194; RX PubMed=18380791; RX PubMed=21607521; RX PubMed=25984343; RX PubMed=31068700; CC Problematic cell line: Contaminated. Parent cell line (KP-1N) has been shown to be a PANC-1 derivative. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Population: Caucasian. CC Doubling time: 25 hours (PubMed=25984343). CC Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=21607521; DepMap=ACH-001108). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=21607521; DepMap=ACH-001108). CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; shRNA library screening. CC Omics: Transcriptomics; Microarray. CC Discontinued: DepMap; ACH-001108; true. CC Discontinued: JCRB; NIHS0274.1; true. CC Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. ST Source(s): JCRB=JCRB0177.1 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 11 ST D16S539: 11 ST D5S818: 11,13 ST D7S820: 8,10 ST TH01: 7,8 ST TPOX: 8,11 ST vWA: 15 DI NCIt; C9120; Pancreatic ductal adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_3002 ! KP-1N SX Male AG 56Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 32 CH CVCL_4Y21 ! KP-1NL-Luc#2 // RX PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x; PMCID=PMC5917979; RA Ikeda, Yurika RA Ezaki, Mitsue RA Hayashi, Itsuro RA Yasuda, Daisuke RA Nakayama, Kazumichi RA Kono, Akira RT "Establishment and characterization of human pancreatic cancer cell RT lines in tissue culture and in nude mice."; RL Jpn. J. Cancer Res. 81:987-993(1990). // RX PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928; RA Suzuki, Ayako RA Shibata, Tatsuhiro RA Shimada, Yutaka RA Murakami, Yoshinori RA Horii, Akira RA Shiratori, Keiko RA Hirohashi, Setsuo RA Inazawa, Johji RA Imoto, Issei RT "Identification of SMURF1 as a possible target for 7q21.3-22.1 RT amplification detected in a pancreatic cancer cell line by in-house RT array-based comparative genomic hybridization."; RL Cancer Sci. 99:986-994(2008). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=21607521; DOI=10.3892/or.1.6.1223; RA Iguchi, Haruo RA Morita, Ryoji RA Yasuda, Daisuke RA Takayanagi, Ryoichi RA Ikeda, Yurika RA Takada, Yutaka RA Shimazoe, Takao RA Nawata, Hajime RA Kono, Akira RT "Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in RT human pancreatic cancer-derived cell-lines with different metastatic RT potential."; RL Oncol. Rep. 1:1223-1227(1994). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). //