ID   KP-1NL
AC   CVCL_3003
SY   KP-1N-L; KP-1-NL; KP1-NL; KP1NL
DR   CLO; CLO_0037106
DR   BioSample; SAMN10989577
DR   cancercelllines; CVCL_3003
DR   Cell_Model_Passport; SIDM01755
DR   CGH-DB; 174-1
DR   CGH-DB; 9369-4
DR   Cosmic; 918048
DR   DepMap; ACH-001108
DR   GEO; GSM1588617
DR   GEO; GSM1588629
DR   IARC_TP53; 30108
DR   JCRB; JCRB0177.1
DR   JCRB; NIHS0274.1
DR   LINCS_LDP; LCL-1794
DR   PharmacoDB; KP1NL_782_2019
DR   Wikidata; Q54900357
RX   PubMed=2172194;
RX   PubMed=18380791;
RX   PubMed=21607521;
RX   PubMed=25984343;
RX   PubMed=31068700;
CC   Problematic cell line: Contaminated. Parent cell line (KP-1N) has been shown to be a PANC-1 derivative.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 25 hours (PubMed=25984343).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=21607521; DepMap=ACH-001108).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=21607521; DepMap=ACH-001108).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Transcriptomics; Microarray.
CC   Discontinued: DepMap; ACH-001108; true.
CC   Discontinued: JCRB; NIHS0274.1; true.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): JCRB=JCRB0177.1
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11
ST   D16S539: 11
ST   D5S818: 11,13
ST   D7S820: 8,10
ST   TH01: 7,8
ST   TPOX: 8,11
ST   vWA: 15
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3002 ! KP-1N
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=2172194; DOI=10.1111/j.1349-7006.1990.tb03336.x; PMCID=PMC5917979;
RA   Ikeda, Yurika
RA   Ezaki, Mitsue
RA   Hayashi, Itsuro
RA   Yasuda, Daisuke
RA   Nakayama, Kazumichi
RA   Kono, Akira
RT   "Establishment and characterization of human pancreatic cancer cell
RT   lines in tissue culture and in nude mice.";
RL   Jpn. J. Cancer Res. 81:987-993(1990).
//
RX   PubMed=18380791; DOI=10.1111/j.1349-7006.2008.00779.x; PMCID=PMC11158928;
RA   Suzuki, Ayako
RA   Shibata, Tatsuhiro
RA   Shimada, Yutaka
RA   Murakami, Yoshinori
RA   Horii, Akira
RA   Shiratori, Keiko
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RA   Imoto, Issei
RT   "Identification of SMURF1 as a possible target for 7q21.3-22.1
RT   amplification detected in a pancreatic cancer cell line by in-house
RT   array-based comparative genomic hybridization.";
RL   Cancer Sci. 99:986-994(2008).
//
RX   PubMed=21607521; DOI=10.3892/or.1.6.1223;
RA   Iguchi, Haruo
RA   Morita, Ryoji
RA   Yasuda, Daisuke
RA   Takayanagi, Ryoichi
RA   Ikeda, Yurika
RA   Takada, Yutaka
RA   Shimazoe, Takao
RA   Nawata, Hajime
RA   Kono, Akira
RT   "Alterations of the p53 tumor-suppressor gene and ki-ras oncogene in
RT   human pancreatic cancer-derived cell-lines with different metastatic
RT   potential.";
RL   Oncol. Rep. 1:1223-1227(1994).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//