ID   DT40-PTPN6(-/-)
AC   CVCL_2G91
SY   SHP1^(-) DT40; SHP-1-deficient DT40
DR   CLO; CLO_0051460
DR   RCB; RCB1466
DR   Wikidata; Q54831510
RX   PubMed=9244303;
RX   PubMed=9547347;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; UniProtKB; F1N843; PTPN6.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_0249 ! DT40
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 22-09-15; Last updated: 30-01-24; Version: 10
RX   PubMed=9244303; DOI=10.1016/S0092-8674(00)80337-2;
RA   Ono M., Okada H., Bolland S., Yanagi S., Kurosaki T., Ravetch J.V.;
RT   "Deletion of SHIP or SHP-1 reveals two distinct pathways for
RT   inhibitory signaling.";
RL   Cell 90:293-301(1997).
RX   PubMed=9547347; DOI=10.1084/jem.187.8.1355;
RA   Maeda A., Kurosaki M., Ono M., Takai T., Kurosaki T.;
RT   "Requirement of SH2-containing protein tyrosine phosphatases SHP-1 and
RT   SHP-2 for paired immunoglobulin-like receptor B (PIR-B)-mediated
RT   inhibitory signal.";
RL   J. Exp. Med. 187:1355-1360(1998).