ID   KMST-6/T
AC   CVCL_2999
DR   BTO; BTO_0002040
DR   JCRB; JCRB0434
DR   Wikidata; Q54900191
RX   PubMed=1537630;
RX   PubMed=8601579;
RX   PubMed=9290701;
CC   Population: Japanese.
CC   Characteristics: Tumorigenic. Established from 2nd-passage tumors obtained in nude mice by transplanting one of the primary tumors produced by subcutaneous inoculation of KMST-6 cells into nude mice.
CC   Doubling time: 37 +- 4.6 hours (Note=In 10% FBS), 47 +- 2.9 hours (Note=In 1% FBS) (PubMed=1537630).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Pro (c.536A>C); ClinVar=VCV000376611; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
CC   Discontinued: JCRB; JCRB0434; true.
CC   Derived from site: In situ; Whole fetus; UBERON=UBERON_0000323.
CC   Cell type: Fibroblast; CL=CL_0000057.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2998 ! KMST-6
SX   Female
AG   9FW
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
//
RX   PubMed=1537630; DOI=10.1002/ijc.2910500426;
RA   Mihara K., Bai L., Kano Y., Miyazaki M., Namba M.;
RT   "Malignant transformation of human fibroblasts previously immortalized
RT   with 60Co gamma rays.";
RL   Int. J. Cancer 50:639-643(1992).
//
RX   PubMed=8601579; DOI=10.1007/BF01209654;
RA   Jahan I., Iijima M., Kondo T., Namba M.;
RT   "Effects of okadaic acid on cell growth, anchorage-independent growth,
RT   and co-cultures of normal (KMS-6), immortalized (KMST-6), and
RT   neoplastically transformed (KMST-6T and KMST-6/RAS) human
RT   fibroblasts.";
RL   J. Cancer Res. Clin. Oncol. 122:249-253(1996).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//