ID   KD [Human lip fibroblast]
AC   CVCL_2970
SY   Karen Day
DR   ATCC; CRL-1295
DR   JCRB; JCRB9103
DR   Wikidata; Q54899703
RX   PubMed=418410;
RX   PubMed=450131;
RX   PubMed=2463881;
RX   PubMed=2902939;
RX   PubMed=3724780;
RX   PubMed=3860870;
RX   PubMed=4842250;
RX   PubMed=6458814;
RX   PubMed=6622549;
RX   PubMed=6621576;
RX   PubMed=7301938;
RX   PubMed=22282976;
CC   Population: Caucasian.
CC   Senescence: Senesces at 38-40 PDL (JCRB=JCRB9103).
CC   Doubling time: 51-70 hours (Note=Lot 06232003), ~27 hours (Note=Lot 11052009), ~36 hours (Note=Lot 12112017) (JCRB=JCRB9103).
CC   Discontinued: ATCC; CRL-1295; true.
CC   Derived from site: In situ; Oral cavity, lip; UBERON=UBERON_0001833.
CC   Cell type: Fibroblast; CL=CL_0000057.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   31Y
CA   Finite cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 14
//
RX   PubMed=418410; DOI=10.1073/pnas.75.3.1334; PMCID=PMC411465;
RA   Kakunaga T.;
RT   "Neoplastic transformation of human diploid fibroblast cells by
RT   chemical carcinogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 75:1334-1338(1978).
//
RX   PubMed=450131; DOI=10.1038/279797a0;
RA   Day R.S. 3rd, Ziolkowski C.H.J.;
RT   "Human brain tumour cell strains with deficient host-cell reactivation
RT   of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.";
RL   Nature 279:797-799(1979).
//
RX   PubMed=2463881; DOI=10.1093/carcin/10.2.265;
RA   Babich M.A., Day R.S. 3rd;
RT   "Synergistic killing of virus-transformed human cells with interferon
RT   and N-methyl-N'-nitro-N-nitrosoguanidine.";
RL   Carcinogenesis 10:265-268(1989).
//
RX   PubMed=2902939; DOI=10.1093/carcin/9.11.2073;
RA   McCormick J.J., Yang D.-J., Maher V.M., Farber R.A., Neuman W.,
RA   Peterson W.D. Jr., Pollack M.S.;
RT   "The HuT series of 'carcinogen-transformed' human fibroblast cell
RT   lines are derived from the human fibrosarcoma cell line 8387.";
RL   Carcinogenesis 9:2073-2079(1988).
//
RX   PubMed=3724780; DOI=10.1016/0167-8817(86)90043-x;
RA   Kantor G.J., Player A.N.;
RT   "A further definition of characteristics of DNA-excision repair in
RT   xeroderma pigmentosum complementation group A strains.";
RL   Mutat. Res. 166:79-88(1986).
//
RX   PubMed=3860870; DOI=10.1073/pnas.82.16.5400; PMCID=PMC390576;
RA   Parshad R., Sanford K.K., Jones G.M.;
RT   "Chromosomal radiosensitivity during the G2 cell-cycle period of skin
RT   fibroblasts from individuals with familial cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:5400-5403(1985).
//
RX   PubMed=4842250;
RA   Day R.S. 3rd;
RT   "Studies on repair of adenovirus 2 by human fibroblasts using normal,
RT   xeroderma pigmentosum, and xeroderma pigmentosum heterozygous
RT   strains.";
RL   Cancer Res. 34:1965-1970(1974).
//
RX   PubMed=6458814; DOI=10.1073/pnas.78.10.6451; PMCID=PMC349057;
RA   Scudiero D.A., Meyer S.A., Clatterbuck B.E., Tarone R.E.,
RA   Robbins J.H.;
RT   "Hypersensitivity to N-methyl-N'-nitro-N-nitrosoguanidine in
RT   fibroblasts from patients with Huntington disease, familial
RT   dysautonomia, and other primary neuronal degenerations.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:6451-6455(1981).
//
RX   PubMed=6622549; DOI=10.1111/j.1751-1097.1983.tb08373.x;
RA   Coohill T.P., Moore S.P., Grider R.A.;
RT   "Action spectra (254-302 nm) for four human photosensitive cell
RT   lines.";
RL   Photochem. Photobiol. 38:105-107(1983).
//
RX   PubMed=6621576; DOI=10.1016/0027-5107(83)90010-6;
RA   Tarone R.E., Scudiero D.A., Robbins J.H.;
RT   "Statistical methods for in vitro cell survival assays.";
RL   Mutat. Res. 111:79-96(1983).
//
RX   PubMed=7301938; DOI=10.1111/j.1751-1097.1981.tb09049.x;
RA   Day R.S. 3rd, Ziolkowski C.H.J., DiMattina M.;
RT   "Decreased host cell reactivation of UV-irradiated adenovirus 5 by
RT   fibroblasts from Cockayne's syndrome patients.";
RL   Photochem. Photobiol. 34:603-607(1981).
//
RX   PubMed=22282976; DOI=10.1093/carcin/1.1.21;
RA   Day R.S. 3rd, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A.,
RA   Mattern M.R.;
RT   "Human tumor cell strains defective in the repair of alkylation
RT   damage.";
RL   Carcinogenesis 1:21-32(1980).
//