AC   CVCL_2959
DR   BTO; BTO:0001949
DR   CLO; CLO_0004307
DR   ATCC; CRL-1730
DR   BioSample; SAMN01821567
DR   BioSample; SAMN01821732
DR   BioSample; SAMN03471415
DR   CCRID; 4201HUM-CCTCC00635
DR   JCRB; IFO50271
DR   KCB; KCB 200648YJ
DR   KCB; KCB 2012087YJ
DR   Lonza; 1085
DR   NCBI_Iran; C554
DR   Wikidata; Q54896935
RX   PubMed=6333682;
RX   PubMed=28755030;
RX   PubMed=29892436;
CC   Senescence: Life expectancy of 50 to 60 population doublings (ATCC=CRL-1730). 54 PDL (PubMed=28755030).
CC   Virology: Contains a chromosomally integrated copy of human herpesvirus 6B (CI-HHV-6B) at the distal end of chromosome 9 (PubMed=28755030).
CC   Doubling time: ~23.5 hours (Note=Between passages 18 and 30), ~67 hours (Note=Between passages 24 and 27), ~84 hours (Note=Between passages 27 and 30), ~100 hours (Note=Between passages 32 and 34) (PubMed=28755030).
CC   Discontinued: IZSLER; BS CL 145; probable.
CC   Derived from site: In situ; Umbilical vein; UBERON=UBERON_0002066.
CC   Cell type: Endothelial cell of umbilical vein; CL=CL_0002618.
ST   Source(s): ATCC; JCRB; PubMed=28755030
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 9,11
ST   D16S539: 11,12
ST   D18S51: 13,17
ST   D21S11: 28,31
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 14,16
ST   FGA: 21,23
ST   Penta D: 12,13
ST   Penta E: 7,13
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 16
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   <1D
CA   Finite cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 24
RX   PubMed=6333682; DOI=10.1073/pnas.81.20.6413;
RA   Hoshi H., McKeehan W.L.;
RT   "Brain- and liver cell-derived factors are required for growth of
RT   human endothelial cells in serum-free culture.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:6413-6417(1984).
RX   PubMed=28755030; DOI=10.1007/s10616-017-0119-y;
RA   Shioda S., Kasai F., Ozawa M., Hirayama N., Satoh M., Kameoka Y.,
RA   Watanabe K., Shimizu N., Tang H.-M., Mori Y., Kohara A.;
RT   "The human vascular endothelial cell line HUV-EC-C harbors the
RT   integrated HHV-6B genome which remains stable in long term culture.";
RL   Cytotechnology 70:141-152(2018).
RX   PubMed=29892436; DOI=10.1098/rsos.172472;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).