ID   HMC-1-8
AC   CVCL_2949
SY   HMC18
DR   CLO; CLO_0037257
DR   EFO; EFO_0022456
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 656
DR   BioSample; SAMN03470817
DR   BioSample; SAMN10987868
DR   cancercelllines; CVCL_2949
DR   Cell_Model_Passport; SIDM01622
DR   DepMap; ACH-000721
DR   IARC_TP53; 28374
DR   JCRB; FDSC0048
DR   JCRB; JCRB0166
DR   LiGeA; CCLE_562
DR   PharmacoDB; HMC18_552_2019
DR   Progenetix; CVCL_2949
DR   SLKBase; 3552
DR   Wikidata; Q54889908
RX   DOI=10.15114/tr.22.27;
RX   PubMed=3488124;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 26 hours (DOI=10.15114/tr.22.27).
CC   HLA typing: A*24:02,31:01; B*07:13,35:08; C*01:02,07:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (DepMap=ACH-000721).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Argfs*18 (c.455delC); ClinVar=VCV000634779; Zygosity=Unspecified (DepMap=ACH-000721).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=83.08%; East Asian, South=16.92%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0048; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): JCRB=JCRB0166
ST   Amelogenin: X
ST   CSF1PO: 7,12
ST   D13S317: 8,10
ST   D16S539: 9,12
ST   D5S818: 9,10
ST   D7S820: 11
ST   TH01: 7,9
ST   TPOX: 8,12
ST   vWA: 16,17
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_H204 ! TcHMC-1
SX   Female
AG   35Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
//
RX   PubMed=3488124;
RA   Sato, Takashi
RA   Sato, Noriyuki
RA   Takahashi, Shuji
RA   Koshiba, Hirofumi
RA   Kikuchi, Kokichi
RT   "Specific cytotoxicity of a long-term cultured T-cell clone on human
RT   autologous mammary cancer cells.";
RL   Cancer Res. 46:4384-4389(1986).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   DOI=10.15114/tr.22.27;
RA   Sato, Takashi
RA   Sato, Noriyuki
RA   Takahashi, Shuji
RA   Okubo, Mamoru
RA   Yagihashi, Atsuhito
RA   Okazaki, Akira
RA   Okazaki, Yutaka
RA   Toda, Kazunori
RA   Hirata, Koichi
RA   Okazaki, Minoru
RA   Asaishi, Kazuaki
RA   Hayasaka, Hiroshi
RA   Kikuchi, Kokichi
RT   "Characterization of two new cancer cell lines derived from human
RT   breast tumors.";
RL   Tumor Res. 22:27-39(1987).
//