ID   V79-4
AC   CVCL_2796
SY   V-79-4; V 79-4
DR   BTO; BTO_0003719
DR   CLO; CLO_0009504
DR   CLO; CLO_0051576
DR   CLDB; cl4632
DR   ATCC; CCL-93
DR   BCRC; 60183
DR   BCRJ; 0244
DR   ChEMBL-Cells; CHEMBL3307246
DR   ChEMBL-Targets; CHEMBL612801
DR   CLS; 603371
DR   ECACC; 93010723
DR   JCRB; JCRB0603
DR   PubChem_Cell_line; CVCL_2796
DR   RCB; RCB2332
DR   Wikidata; Q54992586
RX   PubMed=301865;
RX   PubMed=5392645;
RX   PubMed=9023109;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Widely used to study DNA damage induced by X-ray, UV radiation and oxidizing agents.
CC   Doubling time: 12-14 hours (ECACC=93010723).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (PubMed=9023109).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (PubMed=9023109).
CC   Discontinued: CLS; 603371; true.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_UK06 ! V79-122D1
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
CH   CVCL_1N51 ! irs1
CH   CVCL_1N52 ! irs2
CH   CVCL_1N53 ! irs3
CH   CVCL_5A65 ! V79-ETO1
CH   CVCL_5A66 ! V79-ETO2
CH   CVCL_5A67 ! V79-ETO3
//
RX   PubMed=301865; DOI=10.1080/09553007714550661;
RA   Cox, Roger
RA   Thacker, John
RA   Goodhead, Dudley T.
RT   "Inactivation and mutation of cultured mammalian cells by aluminium
RT   characteristic ultrasoft X-rays. II. Dose-responses of Chinese hamster
RT   and human diploid cells to aluminium X-rays and radiations of
RT   different LET.";
RL   Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 31:561-576(1977).
//
RX   PubMed=9023109; DOI=10.1093/nar/25.5.992; PMCID=PMC146528;
RA   Chaung, Wenren
RA   Mi, Li-Jun
RA   Boorstein, Robert Jay
RT   "The p53 status of Chinese hamster V79 cells frequently used for
RT   studies on DNA damage and DNA repair.";
RL   Nucleic Acids Res. 25:992-994(1997).
//
RX   PubMed=5392645; DOI=10.1093/genetics/62.2.359; PMCID=PMC1212281;
RA   Chu, Ernest H.-Y.
RA   Brimer, Patricia Ann
RA   Jacobson, Karl Bruce
RA   Merriam, Esther Virginia
RT   "Mammalian cell genetics. I. Selection and characterization of
RT   mutations auxotrophic for L-glutamine or resistant to 8-azaguanine in
RT   Chinese hamster cells in vitro.";
RL   Genetics 62:359-377(1969).
//