ID   EZZ (TOU II-4)
AC   CVCL_2781
SY   EZZ; TOU II-4
DR   CLO; CLO_0002956
DR   CLDB; cl1177
DR   ECACC; 93093003
DR   Wikidata; Q54833022
RX   PubMed=6438434;
RX   PubMed=6817143;
WW   Info; IMGT; -; https://www.imgt.org/IMGTrepertoire/LocusGenes/locus/human/IGH/Hu_IGHcellines.html
CC   Population: Tunisian; Berber.
CC   Characteristics: Homozygous for deletion of IGH G1-EP1-A1-GP-G2-G4.
CC   Sequence variation: Gene deletion; HGNC; HGNC:5523; IGHEP1; Zygosity=Homozygous (PubMed=6438434; PubMed=6817143).
CC   Sequence variation: Gene deletion; HGNC; HGNC:5525; IGHG1; Zygosity=Homozygous (PubMed=6438434; PubMed=6817143).
CC   Sequence variation: Gene deletion; HGNC; HGNC:5526; IGHG2; Zygosity=Homozygous (PubMed=6438434; PubMed=6817143).
CC   Sequence variation: Gene deletion; HGNC; HGNC:5528; IGHG4; Zygosity=Homozygous (PubMed=6438434; PubMed=6817143).
CC   Sequence variation: Gene deletion; HGNC; HGNC:5529; IGHGP; Zygosity=Homozygous (PubMed=6438434; PubMed=6817143).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 13
//
RX   PubMed=6817143; DOI=10.1038/300760a0;
RA   Lefranc, Marie-Paule
RA   Lefranc, Gerard
RA   Rabbitts, Terence Howard
RT   "Inherited deletion of immunoglobulin heavy chain constant region
RT   genes in normal human individuals.";
RL   Nature 300:760-762(1982).
//
RX   PubMed=6438434;
RA   Lefranc, Marie-Paule
RA   Lefranc, Gerard
RA   de Lange, Gerda
RA   Out, Theo A.
RA   van den Broek, Peter J.
RA   van Nieuwkoop, Janny
RA   Radl, Jiri
RA   Helal, Ahmed N.
RA   Chaabani, Hassen
RA   van Loghem, Erna
RA   Rabbitts, Terence Howard
RT   "Instability of the human immunoglobulin heavy chain constant region
RT   locus indicated by different inherited chromosomal deletions.";
RL   Mol. Biol. Med. 1:207-217(1983).
//