ID   UM-UC-1
AC   CVCL_2743
SY   UMUC1; University of Michigan-Urothelial Carcinoma-1
DR   BTO; BTO_0006457
DR   EFO; EFO_0006770
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03473231
DR   BioSample; SAMN10988038
DR   cancercelllines; CVCL_2743
DR   CancerTools; 160436
DR   Cell_Model_Passport; SIDM01409
DR   Cosmic; 1927293
DR   Cosmic; 1938699
DR   Cosmic; 2700981
DR   DepMap; ACH-000834
DR   ECACC; 06080301
DR   EGA; EGAS00001000610
DR   GEO; GSM136249
DR   GEO; GSM888823
DR   GEO; GSM1574557
DR   LiGeA; CCLE_460
DR   PharmacoDB; UMUC1_1642_2019
DR   Progenetix; CVCL_2743
DR   Wikidata; Q54990970
RX   PubMed=3761468;
RX   PubMed=6471236;
RX   PubMed=16469639;
RX   PubMed=18812553;
RX   PubMed=19375735;
RX   PubMed=22460905;
RX   PubMed=23401075;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25997541;
RX   PubMed=26589293;
RX   PubMed=27270441;
RX   PubMed=29732388;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; Synapse; Bladder Cancer exome; https://www.synapse.org/Synapse:syn4970200
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Population: African American.
CC   Doubling time: 26 hours (PubMed=3761468).
CC   HLA typing: A*30:02,36:01; B*35:01,53:01; C*04:01,16:01 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1102; BRD1; Simple; p.Gln340Ter (c.1018C>T); Zygosity=Heterozygous (PubMed=27270441).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=85.83%; Native American=0%; East Asian, North=2.25%; East Asian, South=0%; South Asian=0%; European, North=2.87%; European, South=9.04% (PubMed=30894373).
CC   Discontinued: ECACC; 06080301; true.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): ECACC=06080301; PubMed=25877200; PubMed=27270441
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12,14
ST   D16S539: 9,11
ST   D18S51: 15
ST   D21S11: 28,29
ST   D3S1358: 17,18
ST   D5S818: 13
ST   D7S820: 8,11
ST   D8S1179: 12,14
ST   FGA: 22,24
ST   Penta D: 2.2
ST   Penta E: 7,17
ST   TH01: 8
ST   TPOX: 8
ST   vWA: 14,15
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   26Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=23401075; DOI=10.1002/path.4176;
RA   Guo, Ya-Nan
RA   Chekaluk, Yvonne
RA   Zhang, Jian-Ming
RA   Du, Jin-Yan
RA   Gray, Nathanael S.
RA   Wu, Chin-Lee
RA   Kwiatkowski, David Joseph
RT   "TSC1 involvement in bladder cancer: diverse effects and therapeutic
RT   implications.";
RL   J. Pathol. 230:17-27(2013).
//
RX   PubMed=3761468; DOI=10.1016/S0022-5347(17)45139-1;
RA   Grossman, Herbert Barton
RA   Wedemeyer, Gary
RA   Ren, Li-Qin
RA   Wilson, Golder N.
RA   Cox, Beth
RT   "Improved growth of human urothelial carcinoma cell cultures.";
RL   J. Urol. 136:953-959(1986).
//
RX   PubMed=27270441; DOI=10.1038/onc.2016.172; PMCID=PMC5140783;
RA   Nickerson, Michael L.
RA   Witte, Nicolle
RA   McGee Im, Kate
RA   Turan, Sevilay
RA   Owens, Charles R.
RA   Misner, Kevin
RA   Tsang, Shirley X.
RA   Cai, Zhi-Ming
RA   Wu, Sen
RA   Dean, Michael
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Molecular analysis of urothelial cancer cell lines for modeling tumor
RT   biology and drug response.";
RL   Oncogene 36:35-46(2017).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=29732388; DOI=10.3233/BLC-180167; PMCID=PMC5929350;
RA   Zuiverloon, Tahlita C.M.
RA   de Jong, Florus Christiaan
RA   Costello, James C.
RA   Theodorescu, Dan
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=18812553; DOI=10.1093/jnci/djn304; PMCID=PMC2720731;
RA   Park, Hong-Seok
RA   Park, Weon Seo
RA   Bondaruk, Jolanta
RA   Tanaka, Noriyoshi
RA   Katayama, Hiroshi
RA   Lee, Sangkyou
RA   Spiess, Philippe Edouard
RA   Steinberg, Jordan R.
RA   Wang, Zhi
RA   Katz, Ruth L.
RA   Dinney, Colin Padraic Neal
RA   Elias, Keren J.
RA   Lotan, Yair
RA   Naeem, Rizwan C.
RA   Baggerly, Keith
RA   Sen, Subrata
RA   Grossman, Herbert Barton
RA   Czerniak, Bogdan
RT   "Quantitation of Aurora kinase A gene copy number in urine sediments
RT   and bladder cancer detection.";
RL   J. Natl. Cancer Inst. 100:1401-1411(2008).
//
RX   PubMed=25997541; DOI=10.1186/s12864-015-1450-3; PMCID=PMC4470036;
RA   Earl, Julie
RA   Rico, Daniel
RA   Carrillo-de-Santa-Pau, Enrique
RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
RA   Grossman, Herbert Barton
RA   Pisano, David G.
RA   Schulz, Wolfgang Arthur
RA   Perez-Jurado, Luis A.
RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
RT   "The UBC-40 Urothelial Bladder Cancer cell line index: a genomic
RT   resource for functional studies.";
RL   BMC Genomics 16:403.1-403.16(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=16469639; DOI=10.1016/S0022-5347(05)00323-X;
RA   Sabichi, Anita Lyn
RA   Keyhani, Afsaneh
RA   Tanaka, Noriyoshi
RA   Delacerda, Jorge
RA   Lee, I-Ling
RA   Zou, Chang-Ping
RA   Zhou, Jian-Hua
RA   Benedict, William F.
RA   Grossman, Herbert Barton
RT   "Characterization of a panel of cell lines derived from urothelial
RT   neoplasms: genetic alterations, growth in vivo and the relationship of
RT   adenoviral mediated gene transfer to coxsackie adenovirus receptor
RT   expression.";
RL   J. Urol. 175:1133-1137(2006).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=6471236; DOI=10.1016/S0022-5347(17)49883-1;
RA   Grossman, Herbert Barton
RA   Wedemeyer, Gary
RA   Ren, Li-Qin
RT   "UM-UC-1 and UM-UC-2: characterization of two new human transitional
RT   cell carcinoma lines.";
RL   J. Urol. 132:834-837(1984).
//
RX   PubMed=19375735; DOI=10.1016/j.juro.2009.01.108; PMCID=PMC2680455;
RA   Chiong, Edmund
RA   Dadbin, Ali
RA   Harris, Loleta D.
RA   Sabichi, Anita Lyn
RA   Grossman, Herbert Barton
RT   "The use of short tandem repeat profiling to characterize human
RT   bladder cancer cell lines.";
RL   J. Urol. 181:2737-2748(2009).
//