ID   SIRC
AC   CVCL_2724
SY   Sirc; Statens Seruminstitut Rabbit Cornea
DR   BTO; BTO:0004495
DR   CLO; CLO_0009019
DR   CLO; CLO_0009020
DR   CLO; CLO_0050407
DR   CLDB; cl4301
DR   CLDB; cl4302
DR   CLDB; cl4304
DR   CLDB; cl4305
DR   CLDB; cl4306
DR   CLDB; cl4307
DR   ATCC; CCL-60
DR   ATCC; CRL-6595
DR   BCRC; 60093
DR   BCRJ; 0224
DR   ECACC; 89090404
DR   ICLC; AL96001
DR   IZSLER; BS CL 79
DR   JCRB; IFO50020
DR   JCRB; JCRB9122
DR   Lonza; 1197
DR   RCB; RCB1835
DR   TOKU-E; 3120
DR   Wikidata; Q54953505
RX   DOI=10.1007/BF02618370;
RX   PubMed=2228906;
RX   PubMed=5918951;
RX   PubMed=6500159;
RX   PubMed=7989438;
RX   PubMed=14331182;
RX   PubMed=29653143;
RX   PubMed=34737324;
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Characteristics: Expresses a mix of epithelial and fibroblastic markers (PubMed=29653143).
CC   Virology: Can be used for isolation and growth of rubella virus.
CC   Virology: Not susceptible to infection by bovine viral diarrhea virus (BVDV) (PubMed=7989438).
CC   Doubling time: ~31 hours (Note=Lot 11132012), ~1.5 days (Note=Lot 10272017) (JCRB=JCRB9122).
CC   Discontinued: ATCC; CRL-6595; true.
CC   Derived from site: In situ; Eye, cornea; UBERON=UBERON_0000964.
OX   NCBI_TaxID=9986; ! Oryctolagus cuniculus (Rabbit)
SX   Sex unspecified
AG   Age unspecified
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 25
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg C.S., Coriell L.L., Kniazeff A.J., Shannon J.E.;
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=2228906; DOI=10.1007/BF02624618;
RA   Niederkorn J.Y., Meyer D.R., Ubelaker J.E., Martin J.H.;
RT   "Ultrastructural and immunohistological characterization of the SIRC
RT   corneal cell line.";
RL   In Vitro Cell. Dev. Biol. 26:923-930(1990).
//
RX   PubMed=5918951; DOI=10.3181/00379727-122-31251;
RA   Phillips C.A., Melnick J.L., Burkhardt M.;
RT   "Isolation, propagation and neutralization of rubella virus in
RT   cultures of rabbit cornea (SIRC) cells.";
RL   Proc. Soc. Exp. Biol. Med. 122:783-786(1966).
//
RX   PubMed=6500159; DOI=10.1159/000163283;
RA   Gershwin M.E., Lentz D., Owens R.B.;
RT   "Relationship between karyotype of tissue culture lines and
RT   tumorigenicity in nude mice.";
RL   Exp. Cell Biol. 52:361-370(1984).
//
RX   PubMed=7989438; DOI=10.1016/0166-0934(94)90120-1;
RA   Bolin S.R., Ridpath J.F., Black J., Macy M.L., Roblin R.O. III;
RT   "Survey of cell lines in the American Type Culture Collection for
RT   bovine viral diarrhea virus.";
RL   J. Virol. Methods 48:211-221(1994).
//
RX   PubMed=14331182; DOI=10.1126/science.149.3684.633;
RA   Leerhoy J.;
RT   "Cytopathic effect of rubella virus in a rabbit-cornea cell line.";
RL   Science 149:633-634(1965).
//
RX   PubMed=29653143; DOI=10.1016/j.exer.2018.04.004;
RA   Olivieri M., Cristaldi M., Pezzino S., Rusciano D., Tomasello B.,
RA   Anfuso C.D., Lupo G.;
RT   "Phenotypic characterization of the SIRC (Statens Seruminstitut Rabbit
RT   Cornea) cell line reveals a mixed epithelial and fibroblastic
RT   nature.";
RL   Exp. Eye Res. 172:123-127(2018).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5;
RA   Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657-21657(2021).
//