ID   MOG-G-UVW
AC   CVCL_2614
SY   MOG-GUVW; MOGGUVW; GO-G-UVW; G-UVW; UVW; Medical Oncology Glascow-Glioma-UVW
DR   CLO; CLO_0007818
DR   CLDB; cl3513
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 945
DR   BioSample; SAMN03470987
DR   BioSample; SAMN10988296
DR   cancercelllines; CVCL_2614
DR   Cell_Model_Passport; SIDM00504
DR   ChEMBL-Cells; CHEMBL3308137
DR   ChEMBL-Targets; CHEMBL1075508
DR   Cosmic; 908145
DR   Cosmic; 2367539
DR   Cosmic-CLP; 908145
DR   DepMap; ACH-001126
DR   ECACC; 86022703
DR   EGA; EGAS00001000978
DR   GDSC; 90815
DR   GEO; GSM827433
DR   GEO; GSM1374687
DR   GEO; GSM1670123
DR   IARC_TP53; 21510
DR   LINCS_LDP; LCL-1397
DR   PharmacoDB; MOGGUVW_949_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2614
DR   PubChem_Cell_line; CVCL_2614
DR   Wikidata; Q54906313
RX   PubMed=3254724;
RX   PubMed=7518347;
RX   PubMed=7591247;
RX   PubMed=20215515;
RX   PubMed=25877200;
RX   PubMed=27397505;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg110Pro (c.329G>C); ClinVar=VCV000233627; Zygosity=Homozygous (Cosmic-CLP=908145; DepMap=ACH-001126).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.89%; Native American=0%; East Asian, North=2.75%; East Asian, South=0%; South Asian=0%; European, North=58.22%; European, South=37.14% (PubMed=30894373).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): Cosmic-CLP=908145; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 11
ST   D16S539: 13
ST   D18S51: 14,15
ST   D19S433: 14
ST   D21S11: 30,30.2
ST   D2S1338: 21,24
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 9,12
ST   D8S1179: 13,15
ST   FGA: 23,24
ST   Penta D: 9,13
ST   Penta E: 5,7
ST   TH01: 6
ST   TPOX: 8,9
ST   vWA: 15,17
DI   NCIt; C9477; Anaplastic astrocytoma
DI   ORDO; Orphanet_251589; Anaplastic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 37
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=7518347;
RA   Merzak, Abderrahim
RA   Koochekpour, Shahriar
RA   Pilkington, Geoffrey J.
RT   "CD44 mediates human glioma cell adhesion and invasion in vitro.";
RL   Cancer Res. 54:3988-3992(1994).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=3254724; PMCID=PMC2149107;
RA   Mackie, A.E.
RA   Freshney, Robert Ian
RA   Akturk, Fadik
RA   Hunt, G.
RT   "Glucocorticoids and the cell surface of human glioma cells:
RT   relationship to cytostasis.";
RL   Br. J. Cancer Suppl. 9:101-107(1988).
//
RX   PubMed=7591247; DOI=10.1002/ijc.2910630325;
RA   Koochekpour, Shahriar
RA   Pilkington, Geoffrey J.
RA   Merzak, Abderrahim
RT   "Hyaluronic acid/CD44H interaction induces cell detachment and
RT   stimulates migration and invasion of human glioma cells in vitro.";
RL   Int. J. Cancer 63:450-454(1995).
//