ID   MM485
AC   CVCL_2610
SY   MM 485
DR   EFO; EFO_0022369
DR   BioSample; SAMN07624433
DR   cancercelllines; CVCL_2610
DR   CBA; CBA-1355
DR   Cosmic; 889028
DR   Cosmic; 928728
DR   Cosmic; 1206009
DR   Cosmic; 2159428
DR   DepMap; ACH-001973
DR   ECACC; 11072803
DR   GEO; GSM170849
DR   GEO; GSM226724
DR   Progenetix; CVCL_2610
DR   Wikidata; Q54906150
RX   PubMed=1697409;
RX   PubMed=3127479;
RX   PubMed=7780963;
RX   PubMed=9354451;
RX   PubMed=9466661;
RX   PubMed=10070891;
RX   PubMed=15048078;
RX   PubMed=17363583;
RX   PubMed=17516929;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Trp100Ter; Zygosity=Homozygous (PubMed=9354451; PubMed=17363583; DepMap=ACH-001973).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Heterozygous (PubMed=15048078; PubMed=17363583; DepMap=ACH-001973).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
ST   Source(s): CBA=CBA-1355; DepMap=ACH-001973
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11,13
ST   D16S539: 11
ST   D18S51: 13,17
ST   D19S433: 12,14
ST   D21S11: 30
ST   D2S1338: 17,20
ST   D3S1358: 14
ST   D5S818: 11,12
ST   D7S820: 12
ST   D8S1179: 11,13
ST   FGA: 21,23
ST   Penta D: 10,12
ST   Penta E: 10,15
ST   TH01: 8
ST   TPOX: 9,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 27
//
RX   PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152;
RA   Stark, Mitchell S.
RA   Hayward, Nicholas K.
RT   "Genome-wide loss of heterozygosity and copy number analysis in
RT   melanoma using high-density single-nucleotide polymorphism arrays.";
RL   Cancer Res. 67:2632-2642(2007).
//
RX   PubMed=9466661; DOI=10.1002/(SICI)1097-0215(19980209)75:4<590::AID-IJC16>3.0.CO;2-D;
RA   White, Christine A.
RA   Thomson, Scott A.
RA   Cooper, Leanne T.
RA   van Endert, Peter M.
RA   Tampe, Robert
RA   Coupar, Barbara
RA   Qiu, Li
RA   Parsons, Peter G.
RA   Moss, Denis J.
RA   Khanna, Rajiv
RT   "Constitutive transduction of peptide transporter and HLA genes
RT   restores antigen processing function and cytotoxic T cell-mediated
RT   immune recognition of human melanoma cells.";
RL   Int. J. Cancer 75:590-595(1998).
//
RX   PubMed=9354451;
RA   Castellano, Marina
RA   Pollock, Pamela M.
RA   Walters, Marilyn K.
RA   Sparrow, Louise E.
RA   Down, Louise M.
RA   Gabrielli, Brian G.
RA   Parsons, Peter G.
RA   Hayward, Nicholas K.
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey, Sandra
RA   Johansson, Peter
RA   Packer, Leisl
RA   Taylor, Jennifer
RA   Stark, Mitchell S.
RA   Pollock, Pamela M.
RA   Walker, Graeme J.
RA   Boyle, Glen M.
RA   Harper, Ursula
RA   Cozzi, Sarah-Jane
RA   Hansen, Katherine
RA   Yudt, Laura
RA   Schmidt, Chris
RA   Hersey, Peter
RA   Ellem, Kay Adrian Oswald
RA   O'Rourke, Michael G.E.
RA   Parsons, Peter G.
RA   Meltzer, Paul S.
RA   Ringner, Markus
RA   Hayward, Nicholas K.
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=3127479; DOI=10.1111/1523-1747.ep12461022;
RA   McEwan, Max
RA   Parsons, Peter G.
RA   Moss, Denis J.
RT   "Monoclonal antibody against human tyrosinase and reactive with
RT   melanotic and amelanotic melanoma cells.";
RL   J. Invest. Dermatol. 90:515-519(1988).
//
RX   PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x;
RA   Johansson, Peter
RA   Pavey, Sandra
RA   Hayward, Nicholas K.
RT   "Confirmation of a BRAF mutation-associated gene expression signature
RT   in melanoma.";
RL   Pigment Cell Res. 20:216-221(2007).
//
RX   PubMed=1697409;
RA   Chenevix-Trench, Georgia
RA   Martin, Nicholas Gordon
RA   Ellem, Kay Adrian Oswald
RT   "Gene expression in melanoma cell lines and cultured melanocytes:
RT   correlation between levels of c-src-1, c-myc and p53.";
RL   Oncogene 5:1187-1193(1990).
//
RX   PubMed=10070891; DOI=10.1038/sj.bjc.6690147; PMCID=PMC2362648;
RA   Zerp, Shuraila Francisca
RA   van Elsas, Andrea
RA   Peltenburg, Lucy T.C.
RA   Schrier, Peter I.
RT   "p53 mutations in human cutaneous melanoma correlate with sun exposure
RT   but are not always involved in melanomagenesis.";
RL   Br. J. Cancer 79:921-926(1999).
//
RX   PubMed=7780963;
RA   Easty, David J.
RA   Guthrie, Brenda A.
RA   Maung, Kavita
RA   Farr, Christine J.
RA   Lindberg, Richard A.
RA   Toso, Robert J.
RA   Herlyn, Meenhard
RA   Bennett, Dorothy Catherine
RT   "Protein B61 as a new growth factor: expression of B61 and
RT   up-regulation of its receptor epithelial cell kinase during melanoma
RT   progression.";
RL   Cancer Res. 55:2528-2532(1995).
//