ID   KHOS/NP
AC   CVCL_2546
SY   KHOS-NP; KHOS NP; KHOSNP; R-970-5; KHOS
DR   BTO; BTO_0003922
DR   CLO; CLO_0007096
DR   CLO; CLO_0007097
DR   CLO; CLO_0008725
DR   CLDB; cl3030
DR   CLDB; cl3031
DR   ATCC; CRL-1544
DR   ATCC; CRL-7723
DR   cancercelllines; CVCL_2546
DR   ChEMBL-Cells; CHEMBL3308001
DR   ChEMBL-Targets; CHEMBL612598
DR   CLS; 300235
DR   Cosmic; 1044083
DR   Cosmic; 1074393
DR   ECACC; 84102903
DR   GEO; GSM186428
DR   GEO; GSM186429
DR   GEO; GSM827385
DR   GEO; GSM1676341
DR   GEO; GSM1701672
DR   IZSLER; BS TCL 80
DR   LINCS_LDP; LCL-1425
DR   Progenetix; CVCL_2546
DR   PubChem_Cell_line; CVCL_2546
DR   Wikidata; Q54899911
RX   PubMed=2233717;
RX   PubMed=2978869;
RX   PubMed=20215515;
RX   PubMed=26351324;
RX   PubMed=28196595;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Characteristics: Tumorigenic.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; CRL-7723; true.
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
ST   Source(s): ATCC=CRL-1544; CLS=300235; ECACC=84102903
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12
ST   D16S539: 10,13
ST   D18S51: 14,17 (ATCC=CRL-1544)
ST   D18S51: 17 (CLS=300235)
ST   D19S433: 13
ST   D21S11: 31.2,32.2
ST   D2S1338: 24
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 11,12
ST   D8S1179: 11,14
ST   FGA: 24
ST   Penta D: 9,10
ST   Penta E: 7,12
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0439 ! MNNG/HOS Cl #5
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
CH   CVCL_T431 ! KH OS R1
CH   CVCL_2544 ! KHOS-240S
CH   CVCL_2545 ! KHOS-312H
//
RX   PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990; PMCID=PMC361354;
RA   Diller, Lisa
RA   Kassel, Jayne
RA   Nelson, Camille E.
RA   Gryka, Magdalena A.
RA   Litwak, Gregory
RA   Gebhardt, Mark
RA   Bressac, Brigitte
RA   Ozturk, Mehmet
RA   Baker, Suzanne J.
RA   Vogelstein, Bert
RA   Friend, Stephen H.
RT   "p53 functions as a cell cycle control protein in osteosarcomas.";
RL   Mol. Cell. Biol. 10:5772-5781(1990).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=2978869;
RA   Ehrhart, Jean-Claude
RA   Duthu, Arlette
RA   Ullrich, Stephen
RA   Appella, Ettore
RA   May, Pierre
RT   "Specific interaction between a subset of the p53 protein family and
RT   heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.";
RL   Oncogene 3:595-603(1988).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher, Beverly A.
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Monks, Anne
RA   Morris, Joel
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, A. Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//