ID   JIM3
AC   CVCL_2533
SY   JIM-3; Jim3
DR   ArrayExpress; E-TABM-1088
DR   cancercelllines; CVCL_2533
DR   CancerTools; 151450
DR   Cosmic; 720770
DR   Cosmic; 850217
DR   Cosmic; 888016
DR   Cosmic; 2081384
DR   Cosmic; 2367268
DR   Cosmic; 2809767
DR   ECACC; 10081204
DR   IARC_TP53; 28517
DR   Wikidata; Q54898926
DR   Ximbio; 151450
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   PubMed=1943229;
RX   PubMed=8943038;
RX   PubMed=9787181;
RX   PubMed=10087940;
RX   PubMed=10936422;
RX   PubMed=11157491;
RX   PubMed=16956823;
RX   PubMed=17692805;
RX   PubMed=18647998;
RX   PubMed=21173094;
RX   PubMed=25688540;
RX   PubMed=30545397;
RX   PubMed=32123307;
WW   Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
CC   HLA typing: A*02; B*27,40; C*02,03 (PubMed=25688540).
CC   Sequence variation: Gene fusion; HGNC; HGNC:5865; IGLJ3 + HGNC; HGNC:5905; IGLV3-21; Name(s)=IGLV3-21-IGLJ3 (CelloPub=CLPUB00604).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=11157491; PubMed=21173094).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (PubMed=21173094).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Discontinued: ECACC; 10081204; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Plasma cell; CL=CL_0000786.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_2532 ! JIM1
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 28
//
RX   PubMed=10087940; DOI=10.1016/S0165-4608(98)00157-5;
RA   Kuipers, Jeroen
RA   Vaandrager, Jan Willem
RA   Weghuis, Danielle Olde
RA   Pearson, Peter Lees
RA   Scheres, Jacques
RA   Lokhorst, Henk Martinus
RA   Clevers, Hans Cornelius
RA   Bast, Bert J.E.G.
RT   "Fluorescence in situ hybridization analysis shows the frequent
RT   occurrence of 14q32.3 rearrangements with involvement of
RT   immunoglobulin switch regions in myeloma cell lines.";
RL   Cancer Genet. Cytogenet. 109:99-107(1999).
//
RX   PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184;
RA   Dib, Amel
RA   Gabrea, Ana
RA   Glebov, Oleg K.
RA   Bergsagel, Peter Leif
RA   Kuehl, Walter Michael
RT   "Characterization of MYC translocations in multiple myeloma cell
RT   lines.";
RL   J. Natl. Cancer Inst. Monogr. 39:25-31(2008).
//
RX   PubMed=21173094; DOI=10.3324/haematol.2010.033456; PMCID=PMC3069235;
RA   Moreaux, Jerome
RA   Klein, Bernard
RA   Bataille, Francois-Regis
RA   Descamps, Geraldine
RA   Maiga, Sophie
RA   Hose, Dirk
RA   Goldschmidt, Hartmut
RA   Jauch, Anna
RA   Reme, Thierry
RA   Jourdan, Michel
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A high-risk signature for patients with multiple myeloma established
RT   from the molecular classification of human myeloma cell lines.";
RL   Haematologica 96:574-582(2011).
//
RX   PubMed=25688540; DOI=10.1002/cyto.a.22643;
RA   Maiga, Sophie
RA   Brosseau, Carole
RA   Descamps, Geraldine
RA   Dousset, Christelle
RA   Gomez-Bougie, Patricia
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Kervoelen, Charlotte
RA   Vie, Henri
RA   Cesbron, Anne
RA   Moreau-Aubry, Agnes
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "A simple flow cytometry-based barcode for routine authentication of
RT   multiple myeloma and mantle cell lymphoma cell lines.";
RL   Cytometry A 87:285-288(2015).
//
RX   PubMed=11157491; DOI=10.1182/blood.V97.3.729;
RA   Chesi, Marta
RA   Brents, Leslie A.
RA   Ely, Sarah A.
RA   Bais, Carlos
RA   Robbiani, Davide F.
RA   Mesri, Enrique A.
RA   Kuehl, Walter Michael
RA   Bergsagel, Peter Leif
RT   "Activated fibroblast growth factor receptor 3 is an oncogene that
RT   contributes to tumor progression in multiple myeloma.";
RL   Blood 97:729-736(2001).
//
RX   PubMed=16956823;
RA   Bataille, Francois-Regis
RA   Jego, Gaatan
RA   Robillard, Nelly
RA   Barille-Nion, Sophie
RA   Harousseau, Jean-Luc
RA   Moreau, Philippe
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "The phenotype of normal, reactive and malignant plasma cells.
RT   Identification of 'many and multiple myelomas' and of new targets for
RT   myeloma therapy.";
RL   Haematologica 91:1234-1240(2006).
//
RX   PubMed=1943229;
RA   Hamilton, Malcolm S.
RA   Barker, Helen F.
RA   Ball, Jennifer
RA   Drew, Marion
RA   Abbot, Sandra D.
RA   Franklin, Ian Maxwell
RT   "Normal and neoplastic human plasma cells express bcl-2 antigen.";
RL   Leukemia 5:768-771(1991).
//
RX   PubMed=9787181; DOI=10.1182/blood.V92.9.3410;
RA   Sakai, Akira
RA   Thieblemont, Catherine
RA   Wellmann, Axel
RA   Jaffe, Elaine Sarkin
RA   Raffeld, Mark
RT   "PTEN gene alterations in lymphoid neoplasms.";
RL   Blood 92:3410-3415(1998).
//
RX   PubMed=8943038; DOI=10.1073/pnas.93.24.13931; PMCID=PMC19472;
RA   Bergsagel, Peter Leif
RA   Chesi, Marta
RA   Nardini, Elena
RA   Brents, Leslie A.
RA   Kirby, Suzanne Lee
RA   Kuehl, Walter Michael
RT   "Promiscuous translocations into immunoglobulin heavy chain switch
RT   regions in multiple myeloma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996).
//
RX   PubMed=30545397; DOI=10.1186/s13045-018-0679-0; PMCID=PMC6293660;
RA   Tessoulin, Benoit
RA   Moreau-Aubry, Agnes
RA   Descamps, Geraldine
RA   Gomez-Bougie, Patricia
RA   Maiga, Sophie
RA   Gaignard, Alban
RA   Chiron, David
RA   Menoret, Emmanuelle
RA   Le Gouill, Steven
RA   Moreau, Philippe
RA   Amiot, Martine
RA   Pellat-Deceunynck, Catherine
RT   "Whole-exon sequencing of human myeloma cell lines shows mutations
RT   related to myeloma patients at relapse with major hits in the DNA
RT   regulation and repair pathways.";
RL   J. Hematol. Oncol. 11:137.1-137.13(2018).
//
RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler, Hans Gunther
RA   Matsuo, Yoshinobu
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698;
RA   Keats, Jonathan J.
RA   Fonseca, Rafael
RA   Chesi, Marta
RA   Schop, Roelandt
RA   Baker, Angela
RA   Chng, Wee-Joo
RA   Van Wier, Scott
RA   Tiedemann, Rodger
RA   Shi, Chang-Xin
RA   Sebag, Michael
RA   Braggio, Esteban
RA   Henry, Travis
RA   Zhu, Yuan-Xiao
RA   Fogle, Homer
RA   Price-Troska, Tammy L.
RA   Ahmann, Gregory J.
RA   Mancini, Catherine
RA   Brents, Leslie A.
RA   Kumar, Shaji K.
RA   Greipp, Philip Robert
RA   Dispenzieri, Angela
RA   Bryant, Barb
RA   Mulligan, George
RA   Bruhn, Laurakay
RA   Barrett, Michael T.
RA   Valdez, Riccardo
RA   Trent, Jeffrey M.
RA   Stewart, A. Keith
RA   Carpten, John D.
RA   Bergsagel, Peter Leif
RT   "Promiscuous mutations activate the noncanonical NF-kappaB pathway in
RT   multiple myeloma.";
RL   Cancer Cell 12:131-144(2007).
//
RX   CelloPub=CLPUB00604;
RA   Chow, Sharon
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017); University of Toronto; Toronto; Canada.
//
RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund, Helena
RA   Nilsson, Kenneth
RT   "Multiple myeloma cell lines.";
RL   (In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000).
//
RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300;
RA   Sarin, Vishesh
RA   Yu, Katharine
RA   Ferguson, Ian D.
RA   Gugliemini, Olivia
RA   Nix, Matthew A.
RA   Hann, Byron
RA   Sirota, Marina
RA   Wiita, Arun P.
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//