ID   HRT-18
AC   CVCL_2514
SY   HRT18; Human Rectal Tumor-18
DR   BTO; BTO_0001947
DR   CLO; CLO_0003668
DR   CLO; CLO_0003836
DR   CLDB; cl1710
DR   CLDB; cl1711
DR   ATCC; CCL-244
DR   BCRJ; 0106
DR   BioSample; SAMN03471480
DR   BioSample; SAMN10989582
DR   cancercelllines; CVCL_2514
DR   CCLV; CCLV-RIE 0108
DR   Cell_Model_Passport; SIDM00788
DR   ChEMBL-Cells; CHEMBL3308672
DR   ChEMBL-Targets; CHEMBL614834
DR   CLS; 300230
DR   ColonAtlas; HRT18
DR   Cosmic; 724841
DR   DepMap; ACH-001091
DR   ECACC; 86040306
DR   GEO; GSM827431
DR   IZSLER; BS TCL 26
DR   LINCS_LDP; LCL-1289
DR   PharmacoDB; HRT18_567_2019
DR   Progenetix; CVCL_2514
DR   PubChem_Cell_line; CVCL_2514
DR   Wikidata; Q54895337
RX   PubMed=3349466;
RX   PubMed=9809040;
RX   PubMed=12068308;
RX   PubMed=20215515;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   HLA typing: A*02:01:01,24:02:01; B*08:01:01,35:01:01; C*04:01:01,07:01:01; DPB1*01:01:01,04:01:01; DQA1*01:04:01,05:01:01; DQB1*02:01:01,05:03:01G; DRB1*03:01:01,14:54:01 (CLS=300230).
CC   Microsatellite instability: Instable (MSI) (PubMed=31068700).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-001091).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (DepMap=ACH-001091).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.15%; East Asian, North=0.34%; East Asian, South=1.05%; South Asian=1.84%; European, North=63.7%; European, South=32.91% (PubMed=30894373).
CC   Discontinued: CLS; 300230; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): ATCC=CCL-244; CLS=300230; ECACC=86040306; IZSLER=BS TCL 26
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8,11
ST   D16S539: 12,13
ST   D18S51: 11,17
ST   D19S433: 14,16
ST   D21S11: 29,32.2
ST   D2S1338: 17,25
ST   D3S1358: 17
ST   D5S818: 13
ST   D7S820: 10,11.3,12 (ATCC=CCL-244)
ST   D7S820: 10,12 (CLS=300230; ECACC=86040306; IZSLER=BS TCL 26)
ST   D8S1179: 15
ST   FGA: 22
ST   Penta D: 9,14
ST   Penta E: 7,14
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 18,19
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3449 ! __Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 34
//
RX   PubMed=3349466;
RA   Chantret, Isabelle
RA   Barbat, Alain
RA   Dussaulx, Elisabeth
RA   Brattain, Michael G.
RA   Zweibaum, Alain
RT   "Epithelial polarity, villin expression, and enterocytic
RT   differentiation of cultured human colon carcinoma cells: a survey of
RT   twenty cell lines.";
RL   Cancer Res. 48:1936-1942(1988).
//
RX   PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8;
RA   Vermeulen, Stefan Joris
RA   Chen, Tchaw-Ren
RA   Speleman, Frank
RA   Nollet, Friedel
RA   Van Roy, Frans M.
RA   Mareel, Marc M.
RT   "Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18
RT   originate from one and the same patient?";
RL   Cancer Genet. Cytogenet. 107:76-79(1998).
//
RX   PubMed=12068308; DOI=10.1038/nature00766;
RA   Davies, Helen R.
RA   Bignell, Graham Robert
RA   Cox, Charles
RA   Stephens, Philip J.
RA   Edkins, Sarah
RA   Clegg, Sheila
RA   Teague, Jon W.
RA   Woffendin, Hayley
RA   Garnett, Mathew J.
RA   Bottomley, William
RA   Davis, Neil
RA   Dicks, Ed
RA   Ewing, Rebecca
RA   Floyd, Yvonne
RA   Gray, Kristian
RA   Hall, Sarah
RA   Hawes, Rachel
RA   Hughes, Jaime
RA   Kosmidou, Vivian
RA   Menzies, Andrew
RA   Mould, Catherine
RA   Parker, Adrian
RA   Stevens, Claire
RA   Watt, Stephen
RA   Hooper, Steven
RA   Wilson, Rebecca
RA   Jayatilake, Hiran
RA   Gusterson, Barry Austin
RA   Cooper, Colin S.
RA   Shipley, Janet M.
RA   Hargrave, Darren
RA   Pritchard-Jones, Kathy
RA   Maitland, Norman J.
RA   Chenevix-Trench, Georgia
RA   Riggins, Gregory J.
RA   Bigner, Darell Doty
RA   Palmieri, Giuseppe
RA   Cossu, Antonio
RA   Flanagan, Adrienne M.
RA   Nicholson, Andrew
RA   Ho, Judy W.C.
RA   Leung, Suet Yi
RA   Yuen, Siu Tsan
RA   Weber, Barbara L.
RA   Seigler, Hilliard Foster
RA   Darrow, Timothy L.
RA   Paterson, Hugh F.
RA   Marais, Richard
RA   Marshall, Christopher John
RA   Wooster, Richard
RA   Stratton, Michael Rudolf
RA   Futreal, P. Andrew
RT   "Mutations of the BRAF gene in human cancer.";
RL   Nature 417:949-954(2002).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//