ID HRT-18 AC CVCL_2514 SY HRT18; Human Rectal Tumor-18 DR BTO; BTO_0001947 DR CLO; CLO_0003668 DR CLO; CLO_0003836 DR CLDB; cl1710 DR CLDB; cl1711 DR ATCC; CCL-244 DR BCRJ; 0106 DR BioSample; SAMN03471480 DR BioSample; SAMN10989582 DR cancercelllines; CVCL_2514 DR CCLV; CCLV-RIE 0108 DR Cell_Model_Passport; SIDM00788 DR ChEMBL-Cells; CHEMBL3308672 DR ChEMBL-Targets; CHEMBL614834 DR CLS; 300230 DR ColonAtlas; HRT18 DR Cosmic; 724841 DR DepMap; ACH-001091 DR ECACC; 86040306 DR GEO; GSM827431 DR IZSLER; BS TCL 26 DR LINCS_LDP; LCL-1289 DR PharmacoDB; HRT18_567_2019 DR Progenetix; CVCL_2514 DR PubChem_Cell_line; CVCL_2514 DR Wikidata; Q54895337 RX PubMed=3349466; RX PubMed=9809040; RX PubMed=12068308; RX PubMed=20215515; RX PubMed=30894373; RX PubMed=31068700; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Population: Caucasian. CC HLA typing: A*02:01:01,24:02:01; B*08:01:01,35:01:01; C*04:01:01,07:01:01; DPB1*01:01:01,04:01:01; DQA1*01:04:01,05:01:01; DQB1*02:01:01,05:03:01G; DRB1*03:01:01,14:54:01 (CLS=300230). CC Microsatellite instability: Instable (MSI) (PubMed=31068700). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12068308; DepMap=ACH-001091). CC Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (DepMap=ACH-001091). CC Omics: Genomics; Whole exome sequencing. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.15%; East Asian, North=0.34%; East Asian, South=1.05%; South Asian=1.84%; European, North=63.7%; European, South=32.91% (PubMed=30894373). CC Discontinued: CLS; 300230; true. CC Derived from site: In situ; Colon; UBERON=UBERON_0001155. CC Cell type: Epithelial cell of colon; CL=CL_0011108. ST Source(s): ATCC=CCL-244; CLS=300230; ECACC=86040306; IZSLER=BS TCL 26 ST Amelogenin: X,Y ST CSF1PO: 12 ST D13S317: 8,11 ST D16S539: 12,13 ST D18S51: 11,17 ST D19S433: 14,16 ST D21S11: 29,32.2 ST D2S1338: 17,25 ST D3S1358: 17 ST D5S818: 13 ST D7S820: 10,11.3,12 (ATCC=CCL-244) ST D7S820: 10,12 (CLS=300230; ECACC=86040306; IZSLER=BS TCL 26) ST D8S1179: 15 ST FGA: 22 ST Penta D: 9,14 ST Penta E: 7,14 ST TH01: 7,9.3 ST TPOX: 8,11 ST vWA: 18,19 DI NCIt; C4349; Colon adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_3449 ! __Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18 SX Male AG 67Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 34 CH CVCL_2515 ! HRT-18G // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathryn RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne Margaret RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=3349466; RA Chantret, Isabelle RA Barbat, Alain RA Dussaulx, Elisabeth RA Brattain, Michael G. RA Zweibaum, Alain RT "Epithelial polarity, villin expression, and enterocytic RT differentiation of cultured human colon carcinoma cells: a survey of RT twenty cell lines."; RL Cancer Res. 48:1936-1942(1988). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8; RA Vermeulen, Stefan Joris RA Chen, Tchaw-Ren RA Speleman, Frank RA Nollet, Friedel RA Van Roy, Frans M. RA Mareel, Marc M. RT "Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 RT originate from one and the same patient?"; RL Cancer Genet. Cytogenet. 107:76-79(1998). //