ID   HRA-19a1.1 Alpha2Alpha1 E
AC   CVCL_2511
DR   cancercelllines; CVCL_2511
DR   ECACC; 09071527
DR   Wikidata; Q54895219
RX   PubMed=18664572;
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg405Ter (c.1213C>T); ClinVar=VCV000127275; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Ser16Alafs*27 (c.42_45delTCTT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6137; ITGA2 (Note=Chimeric extracellular and TM domain of ITGA2 and the cytoplasmic domain of ITGA1).
CC   Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
ST   Source(s): ECACC=09071527
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D5S818: 11
ST   D7S820: 9,12
ST   TH01: 8
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C9383; Rectal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2509 ! HRA-19a1.1
SX   Male
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
//
RX   PubMed=18664572; DOI=10.1074/jbc.M802932200; PMCID=PMC2562061;
RA   Kirkland, Susan C.
RA   Ying, Hui-Jun
RT   "Alpha2beta1 integrin regulates lineage commitment in multipotent
RT   human colorectal cancer cells.";
RL   J. Biol. Chem. 283:27612-27619(2008).
//