ID   HMT-3522 S2
AC   CVCL_2500
SY   HMT-3522-S2; HMT-3522S2; HMT3522S2; S2; S-2; HMT-3522/gt-1; gt-1; HMT-3522/growth-transformed-1
DR   cancercelllines; CVCL_2500
DR   Cosmic; 889086
DR   Cosmic; 1066170
DR   ECACC; 98102211
DR   Wikidata; Q54889969
RX   PubMed=7982476;
RX   PubMed=8616848;
RX   PubMed=18316601;
CC   Population: Caucasian.
CC   Characteristics: Established from parent cell line by permanent ommission of EGF in culture medium.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (PubMed=7982476).
CC   Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
ST   Source(s): ECACC=98102211
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,13
ST   D5S818: 9,11
ST   D7S820: 9
ST   TH01: 9,9.3
ST   TPOX: 11
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6855 ! HMT-3522
SX   Female
AG   50Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 20
CH   CVCL_2501 ! HMT-3522 T4-2
//
RX   PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225; PMCID=PMC2662716;
RA   Rizki, Aylin
RA   Weaver, Valerie Marie
RA   Lee, Sun-Young
RA   Rozenberg, Gabriela I.
RA   Chin, Koei
RA   Myers, Connie A.
RA   Bascom, Jamie L.
RA   Mott, Joni D.
RA   Semeiks, Jeremy R.
RA   Grate, Leslie Roy
RA   Mian, I. Saira
RA   Borowsky, Alexander David
RA   Jensen, Roy A.
RA   Idowu, Michael O.
RA   Chen, Fan-Qing
RA   Chen, David J.
RA   Petersen, Ole William
RA   Gray, Joe W.
RA   Bissell, Mina J.
RT   "A human breast cell model of preinvasive to invasive transition.";
RL   Cancer Res. 68:1378-1387(2008).
//
RX   PubMed=8616848;
RA   Briand, Per
RA   Nielsen, Kirsten Vang
RA   Madsen, Mogens W.
RA   Petersen, Ole William
RT   "Trisomy 7p and malignant transformation of human breast epithelial
RT   cells following epidermal growth factor withdrawal.";
RL   Cancer Res. 56:2039-2044(1996).
//
RX   PubMed=7982476; DOI=10.1006/excr.1994.1355;
RA   Moyret, Caroline
RA   Madsen, Mogens W.
RA   Cooke, Jeff
RA   Briand, Per
RA   Theillet, Charles
RT   "Gradual selection of a cellular clone presenting a mutation at codon
RT   179 of the p53 gene during establishment of the immortalized human
RT   breast epithelial cell line HMT-3522.";
RL   Exp. Cell Res. 215:380-385(1994).
//