ID   HMT-3522 S2
AC   CVCL_2500
SY   HMT-3522-S2; HMT-3522S2; HMT3522S2; S2; S-2; HMT-3522/gt-1; gt-1; HMT-3522/growth-transformed-1
DR   cancercelllines; CVCL_2500
DR   Cosmic; 889086
DR   Cosmic; 1066170
DR   ECACC; 98102211
DR   Wikidata; Q54889969
RX   PubMed=7982476;
RX   PubMed=8616848;
RX   PubMed=18316601;
CC   Population: Caucasian.
CC   Characteristics: Established from parent cell line by permanent ommission of EGF in culture medium.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (PubMed=7982476).
CC   Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
CC   Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
ST   Source(s): ECACC=98102211
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,13
ST   D5S818: 9,11
ST   D7S820: 9
ST   TH01: 9,9.3
ST   TPOX: 11
ST   vWA: 14,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6855 ! HMT-3522
SX   Female
AG   50Y
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 18
RX   PubMed=7982476; DOI=10.1006/excr.1994.1355;
RA   Moyret C., Madsen M.W., Cooke J., Briand P., Theillet C.;
RT   "Gradual selection of a cellular clone presenting a mutation at codon
RT   179 of the p53 gene during establishment of the immortalized human
RT   breast epithelial cell line HMT-3522.";
RL   Exp. Cell Res. 215:380-385(1994).
RX   PubMed=8616848;
RA   Briand P., Nielsen K.V., Madsen M.W., Petersen O.W.;
RT   "Trisomy 7p and malignant transformation of human breast epithelial
RT   cells following epidermal growth factor withdrawal.";
RL   Cancer Res. 56:2039-2044(1996).
RX   PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225;
RA   Rizki A., Weaver V.M., Lee S.-Y., Rozenberg G.I., Chin K., Myers C.A.,
RA   Bascom J.L., Mott J.D., Semeiks J.R., Grate L.R., Mian I.S.,
RA   Borowsky A.D., Jensen R.A., Idowu M.O., Chen F.-Q., Chen D.J.,
RA   Petersen O.W., Gray J.W., Bissell M.J.;
RT   "A human breast cell model of preinvasive to invasive transition.";
RL   Cancer Res. 68:1378-1387(2008).