ID   H357
AC   CVCL_2462
DR   CancerTools; 153422
DR   Cell_Model_Passport; SIDM01810
DR   Cosmic; 716676
DR   Cosmic; 916370
DR   Cosmic; 928237
DR   DepMap; ACH-001509
DR   ECACC; 06092004
DR   Wikidata; Q54872075
DR   Ximbio; 153422
RX   PubMed=1692339;
RX   PubMed=7633286;
RX   PubMed=8552382;
RX   PubMed=17944752;
RX   PubMed=20426848;
RX   PubMed=27846777;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly13Ser (c.37G>A); ClinVar=VCV000376323; Zygosity=Unspecified (DepMap=ACH-001509).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg110Cys (c.328C>T); ClinVar=VCV000142206; Zygosity=Homozygous (PubMed=7633286).
CC   Discontinued: ECACC; 06092004; true.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): DepMap=ACH-001509
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 12,13
ST   D16S539: 11,12
ST   D18S51: 14,17
ST   D21S11: 29,31.2
ST   D3S1358: 17,18
ST   D5S818: 12,14
ST   D7S820: 11
ST   D8S1179: 13
ST   FGA: 23,26
ST   Penta D: 6,12
ST   Penta E: 11,13
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 17,19
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   74Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 20
//
RX   PubMed=1692339; DOI=10.1002/path.1711600313;
RA   Prime S.S., Nixon S.V.R., Crane I.J., Stone A., Matthews J.B.,
RA   Maitland N.J., Remnant L., Powell S.K., Game S.M., Scully C.;
RT   "The behaviour of human oral squamous cell carcinoma in cell
RT   culture.";
RL   J. Pathol. 160:259-269(1990).
//
RX   PubMed=7633286; DOI=10.1016/0964-1955(94)00030-8;
RA   Yeudall W.A., Paterson I.C., Patel V., Prime S.S.;
RT   "Presence of human papillomavirus sequences in tumour-derived human
RT   oral keratinocytes expressing mutant p53.";
RL   Eur. J. Cancer B. Oral Oncol. 31:136-143(1995).
//
RX   PubMed=8552382;
RA   Jones J., Sugiyama M., Speight P.M., Watt F.M.;
RT   "Restoration of alpha V beta 5 integrin expression in neoplastic
RT   keratinocytes results in increased capacity for terminal
RT   differentiation and suppression of anchorage-independent growth.";
RL   Oncogene 12:119-126(1996).
//
RX   PubMed=17944752; DOI=10.1111/j.1600-0714.2007.00617.x;
RA   Harper L.J., Piper K., Common J.E.A., Fortune F., Mackenzie I.C.;
RT   "Stem cell patterns in cell lines derived from head and neck squamous
RT   cell carcinoma.";
RL   J. Oral Pathol. Med. 36:594-603(2007).
//
RX   PubMed=20426848; DOI=10.1186/1471-2407-10-166; PMCID=PMC2868812;
RA   Harper L.J., Costea D.E., Gammon L., Fazil B., Biddle A.,
RA   Mackenzie I.C.;
RT   "Normal and malignant epithelial cells with stem-like properties have
RT   an extended G2 cell cycle phase that is associated with apoptotic
RT   resistance.";
RL   BMC Cancer 10:166.1-166.16(2010).
//
RX   PubMed=27846777; DOI=10.1089/ten.TEC.2016.0310;
RA   Jennings L.R., Colley H.E., Ong J., Panagakos F., Masters J.G.,
RA   Trivedi H.M., Murdoch C., Whawell S.A.;
RT   "Development and characterization of in vitro human oral mucosal
RT   equivalents derived from immortalized oral keratinocytes.";
RL   Tissue Eng. Part C. Methods 22:1108-1117(2016).
//