ID   h1RPE7
AC   CVCL_2459
SY   h1RPE-7
DR   ECACC; 09061602
DR   Wikidata; Q54871994
RX   PubMed=11504951;
RX   PubMed=11818403;
RX   PubMed=25177495;
CC   Doubling time: ~24 hours (ECACC=09061602).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
ST   Source(s): ECACC=09061602
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 12
ST   D16S539: 12
ST   D5S818: 9,13
ST   D7S820: 9,10
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 16,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_9W31 ! h1RPE116
SX   Female
AG   50Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 17
//
RX   PubMed=11504951; DOI=10.1073/pnas.171266298; PMCID=PMC55557;
RA   Lund R.D., Adamson P., Sauve Y., Keegan D.J., Girman S.V., Wang S.-M.,
RA   Winton H.L., Kanuga N., Kwan A.S.L., Beauchene L., Zerbib A.,
RA   Hetherington L., Couraud P.-O., Coffey P., Greenwood J.;
RT   "Subretinal transplantation of genetically modified human cell lines
RT   attenuates loss of visual function in dystrophic rats.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9942-9947(2001).
//
RX   PubMed=11818403;
RA   Kanuga N., Winton H.L., Beauchene L., Koman A., Zerbib A., Halford S.,
RA   Couraud P.-O., Keegan D.J., Coffey P., Lund R.D., Adamson P.,
RA   Greenwood J.;
RT   "Characterization of genetically modified human retinal pigment
RT   epithelial cells developed for in vitro and transplantation studies.";
RL   Invest. Ophthalmol. Vis. Sci. 43:546-555(2002).
//
RX   PubMed=25177495; DOI=10.1155/2014/801787; PMCID=PMC4142280;
RA   Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.;
RT   "Cell models to study regulation of cell transformation in pathologies
RT   of retinal pigment epithelium.";
RL   J. Ophthalmol. 2014:801787.1-801787.18(2014).
//