ID   CRFK
AC   CVCL_2426
SY   CrFK; Crfk; NBL-CrFK; Crandell Reese Feline Kidney; CFK; Crandell Feline Kidney; CCC; Crandell's Cat Cell
DR   CLO; CLO_0002609
DR   CLDB; cl907
DR   CLDB; cl908
DR   ATCC; CCL-94
DR   ATCC; CRL-6073
DR   BCRC; 60151
DR   BCRJ; 0072
DR   CCRID; 1102MAM-NIFDC00047
DR   CCRID; 3101MAMGNO16
DR   CCRID; 4201MAM-CCTCC00321
DR   CCTCC; GDC0321
DR   ECACC; 86093002
DR   IZSLER; BS CL 22
DR   JCRB; JCRB9035
DR   KCB; KCB 200974YJ
DR   KCLB; 10094
DR   Lonza; 801
DR   TOKU-E; 997
DR   Wikidata; Q54814484
RX   PubMed=75945;
RX   PubMed=1313703;
RX   PubMed=4130570;
RX   PubMed=6160900;
RX   PubMed=9696876;
RX   PubMed=20631117;
RX   PubMed=21029758;
RX   PubMed=23585909;
WW   Info; Evident; -; https://evidentscientific.com/en/microscope-resource/image-gallery/confocal/epithelialindex
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-435.html
CC   Group: Vaccine production cell line.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Biotechnology: Widely used to manufacture vaccines for parvoviruses such as feline panleukopenia virus (FPLV) and canine parvoviruses (CPVs).
CC   Virology: Persistently infected by feline endogenous virus RD-114.
CC   Discontinued: ATCC; CRL-6073; true.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
OX   NCBI_TaxID=9685; ! Felis catus (Cat)
HI   CVCL_DB45 ! FCK
SX   Female
AG   3M
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
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RX   PubMed=75945; DOI=10.1099/0022-1317-38-3-483;
RA   O'Brien S.J., Simonson J.M., Davis S.;
RT   "Deposition of retrovirus associated antigens (p30 and gp70) on cell
RT   membranes of feline and murine leukaemia virus infected cells.";
RL   J. Gen. Virol. 38:483-496(1978).
//
RX   PubMed=1313703; DOI=10.1292/jvms.54.173;
RA   Miyazawa T., Toyosaki T., Tomonaga K., Norimine J., Ohno K.,
RA   Hasegawa A., Kai C., Mikami T.;
RT   "Further characterization of a feline T-lymphoblastoid cell line (MYA-1
RT   cells) highly sensitive for feline immunodeficiency virus.";
RL   J. Vet. Med. Sci. 54:173-175(1992).
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RX   PubMed=4130570; DOI=10.1007/BF02618435;
RA   Crandell R.A., Fabricant C.G., Nelson-Rees W.A.;
RT   "Development, characterization, and viral susceptibility of a feline
RT   (Felis catus) renal cell line (CRFK).";
RL   In Vitro 9:176-185(1973).
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RX   PubMed=6160900; PMCID=PMC1320103;
RA   Fulton R.W., Pearson N.J.;
RT   "Interferon production by bovine tracheal organ cultures infected with
RT   bovid herpesvirus 1 strains.";
RL   Can. J. Comp. Med. 44:447-452(1980).
//
RX   PubMed=9696876; DOI=10.1128/JVI.72.9.7685-7687.1998; PMCID=PMC110043;
RA   Baumann J.G., Gunzburg W.H., Salmons B.;
RT   "CrFK feline kidney cells produce an RD114-like endogenous virus that
RT   can package murine leukemia virus-based vectors.";
RL   J. Virol. 72:7685-7687(1998).
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RX   PubMed=20631117; DOI=10.1128/jcm.00992-10; PMCID=PMC2937671;
RA   Yoshikawa R., Sato E., Igarashi T., Miyazawa T.;
RT   "Characterization of RD-114 virus isolated from a commercial canine
RT   vaccine manufactured using CRFK cells.";
RL   J. Clin. Microbiol. 48:3366-3369(2010).
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RX   PubMed=21029758; DOI=10.1016/j.virusres.2010.10.020;
RA   Okada M., Yoshikawa R., Shojima T., Baba K., Miyazawa T.;
RT   "Susceptibility and production of a feline endogenous retrovirus
RT   (RD-114 virus) in various feline cell lines.";
RL   Virus Res. 155:268-273(2011).
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RX   PubMed=23585909; DOI=10.1371/journal.pone.0061530; PMCID=PMC3621756;
RA   Fukuma A., Yoshikawa R., Miyazawa T., Yasuda J.;
RT   "A new approach to establish a cell line with reduced risk of
RT   endogenous retroviruses.";
RL   PLoS ONE 8:e61530.1-e61530.5(2013).
//