ID   46BR.1G1
AC   CVCL_2288
SY   46Br.1G1; 46BR 1G1; 46BR-1G1
DR   BTO; BTO_0005012
DR   CLO; CLO_0001380
DR   CLDB; cl100
DR   ECACC; 92091814
DR   Wikidata; Q54603230
RX   PubMed=2903889;
RX   PubMed=3002824;
RX   PubMed=3180052;
RX   PubMed=7683758;
RX   PubMed=22222975;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:6598; LIG1; Simple; p.Glu566Lys (c.1696G>A); ClinVar=VCV000016775; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6598; LIG1; Simple; p.Arg771Trp (c.2311C>T); ClinVar=VCV000016776; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSV3-gpt).
CC   Omics: Proteomics; 2DE-MS.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C122658; DNA ligase I deficiency
DI   NCIt; C26931; Hypogammaglobulinemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_L943 ! 46BR
SX   Female
AG   18Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 26
CH   CVCL_L950 ! 46BRLigI
//
RX   PubMed=22222975; DOI=10.1002/elps.201100332;
RA   Giuliano, Serena
RA   Iadarola, Paolo
RA   Leva, Valentina
RA   Montecucco, Alessandra
RA   Camerini, Serena
RA   Crescenzi, Marco
RA   Salvini, Roberta
RA   Bardoni, Anna
RT   "An insight into the abundant proteome of 46BR.1G1 fibroblasts
RT   deficient of DNA ligase I.";
RL   Electrophoresis 33:307-315(2012).
//
RX   PubMed=3002824; DOI=10.1016/0014-4827(86)90356-3;
RA   Mayne, Lynne V.
RA   Priestley, Anne
RA   James, Michael R.
RA   Burke, Julian F.
RT   "Efficient immortalization and morphological transformation of human
RT   fibroblasts by transfection with SV40 DNA linked to a dominant
RT   marker.";
RL   Exp. Cell Res. 162:530-538(1986).
//
RX   PubMed=3180052;
RA   Lehmann, Alan Robert
RA   Willis, Anne Elizabeth
RA   Broughton, Bernard C.
RA   James, Michael R.
RA   Steingrimsdottir, Herdis
RA   Harcourt, Susan A.
RA   Arlett, Colin Francis
RA   Lindahl, Tomas Robert
RT   "Relation between the human fibroblast strain 46BR and cell lines
RT   representative of Bloom's syndrome.";
RL   Cancer Res. 48:6343-6347(1988).
//
RX   PubMed=7683758; DOI=10.1016/0921-8777(93)90057-N;
RA   Somia, Nikunj V.
RA   Jessop, J. Kirsty
RA   Melton, David W.
RT   "Phenotypic correction of a human cell line (46BR) with aberrant DNA
RT   ligase I activity.";
RL   Mutat. Res. 294:51-58(1993).
//
RX   PubMed=2903889; DOI=10.1080/09553008814552321;
RA   Arlett, Colin Francis
RA   Green, Michael H.L.
RA   Priestley, Anne
RA   Harcourt, Susan A.
RA   Mayne, Lynne V.
RT   "Comparative human cellular radiosensitivity: I. The effect of SV40
RT   transformation and immortalisation on the gamma-irradiation survival
RT   of skin derived fibroblasts from normal individuals and from
RT   ataxia-telangiectasia patients and heterozygotes.";
RL   Int. J. Radiat. Biol. 54:911-928(1988).
//