ID   SK-UT-1B
AC   CVCL_2250
SY   SKUT1B; SK-UT 1B; SKUT-1B; Skut1B
DR   BTO; BTO_0003725
DR   CLO; CLO_0009066
DR   CLDB; cl4359
DR   ATCC; HTB-115
DR   BioSample; SAMN03471096
DR   BioSample; SAMN03472878
DR   cancercelllines; CVCL_2250
DR   CancerTools; 161939
DR   ChEMBL-Cells; CHEMBL3307682
DR   ChEMBL-Targets; CHEMBL614678
DR   CLS; 300406
DR   Cosmic; 713478
DR   Cosmic; 871555
DR   Cosmic; 889118
DR   Cosmic; 1007164
DR   Cosmic; 1066227
DR   Cosmic; 1091505
DR   GEO; GSM185152
DR   GEO; GSM185153
DR   GEO; GSM844693
DR   GEO; GSM844694
DR   GEO; GSM1676334
DR   GEO; GSM1701666
DR   IGRhCellID; SKUT1B
DR   IZSLER; BS TCL 210
DR   Progenetix; CVCL_2250
DR   PubChem_Cell_line; CVCL_2250
DR   Wikidata; Q54954651
RX   PubMed=327080;
RX   PubMed=2372783;
RX   PubMed=2766249;
RX   PubMed=3383166;
RX   PubMed=3518877;
RX   PubMed=6935474;
RX   PubMed=9541971;
RX   PubMed=25877200;
RX   PubMed=26351324;
RX   PubMed=28196595;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Provider; MSKCC; -; https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-ut-1b-human-uterine-leiomyosarcoma-cell-line
CC   Part of: MD Anderson Cell Lines Project.
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2010-071.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1096Ter (c.3286C>T); ClinVar=VCV000156475; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg88Gln (c.263G>A); ClinVar=VCV000376049; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323fs*2 (c.968_969insA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); ClinVar=VCV002724056; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
ST   Source(s): ATCC=HTB-115; CLS=300406; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 10,13
ST   D16S539: 12,14
ST   D18S51: 11,17
ST   D19S433: 12,13
ST   D21S11: 29,32.2
ST   D2S1338: 19,21
ST   D3S1358: 15,16
ST   D5S818: 10,11
ST   D7S820: 9,10
ST   D8S1179: 14,15
ST   FGA: 22,23
ST   Penta D: 11,14
ST   Penta E: 17
ST   TH01: 7
ST   TPOX: 5,8 (PubMed=25877200)
ST   TPOX: 8 (ATCC=HTB-115; CLS=300406)
ST   vWA: 16
DI   NCIt; C6340; Uterine corpus leiomyosarcoma
DI   ORDO; Orphanet_213625; Leiomyosarcoma of the corpus uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0533 ! SK-UT-1
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright, William C.
RA   Daniels, Walter P.
RA   Fogh, Jorgen
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=9541971;
RA   Poljanskaia, Galina Georgievna
RA   Efremova, Tatiana N.
RA   Ender, Natalia A.
RT   "The influence of mycoplasmal contamination of the human uterine
RT   leiomyosarcoma cell line SK-UT-1B on karyotype structure.";
RL   Tsitologiia 40:23-30(1998).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher, Beverly A.
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Monks, Anne
RA   Morris, Joel
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=3383166; DOI=10.1016/0165-4608(88)90052-0;
RA   Chen, Tchaw-Ren
RT   "SK-UT-1B, a human tumorigenic diploid cell line.";
RL   Cancer Genet. Cytogenet. 33:77-81(1988).
//
RX   PubMed=2766249; DOI=10.1016/0165-4608(89)90119-2;
RA   Pathak, Sen
RA   Dhaliwal, Manjeet K.
RT   "Cytogenetic analysis of a leiomyosarcoma cell line (SK-UT-1B). Normal
RT   diploid or with 21q deletion?";
RL   Cancer Genet. Cytogenet. 41:145-147(1989).
//
RX   PubMed=2372783; DOI=10.1016/0165-4608(90)90229-4;
RA   Chen, Tchaw-Ren
RT   "SK-UT-1B cell line has the diploid karyotype -- a reply.";
RL   Cancer Genet. Cytogenet. 48:139-141(1990).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh, Jorgen
RA   Fogh, Jens M.
RA   Orfeo, Thomas
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//